Longitudinal Study of Intestinal Symptoms and Fecal Continence in Patients With Conformal Radiotherapy for Prostate Cancer

Geinitz, Hans; Thamm, Reinhard; Keller, Monika; Astner, Sabrina T.; Heinrich, Christine; Scholz, Christian W.; Pehl, C.; Kerndl, Simone; Prause, N; Busch, Raymonde; Molls, M.; Zimmermann, Frank

doi:10.1016/j.ijrobp.2010.01.033

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…DVH data of the herein analyzed patient group compare favorably to the data of a patient sample that was treated previously with 3D conformal radiotherapy to doses of 74 Gy at our institution using 10 mm margins without daily image guidance [8]. Rectal V35, V50, and V65 in that sample were 47%, 35%, and 22% as compared to 48%, 27%, and 14%, respectively, in the present study.…”

Section: Discussionsupporting

confidence: 64%

Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy

et al. 2012

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Section: Discussionsupporting

confidence: 64%

Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy

et al. 2012

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“…These traits underlying clinical symptoms, such as bone loss, osteoporotic fractures [66][67][68], and for high-dose radiation treatment, pelvic pain [67], were deeply analyzed up to a year post-RT [68]. Patients suffered from rectal bleeding and fecal continence as a post-treatment side-effect to prostate cancer therapy [69] and reduced BMD following their cervical cancer radiation treatment, often depending on their age and age-related menopausal status [68]. Bone loss was further determined for RT plus androgen deprivation therapy in case of locally advanced prostate cancer [70].…”

Section: Microbiota Influence Rt and Clinical Datamentioning

confidence: 99%

Radiation Impacts Microbiota Compositions That Activate Transforming Growth Factor-Beta Expression in the Small Intestine

Maier

2023

Microbiology Research

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The composition of the gut microbiota represents an early indicator of chronic post-radiation outcomes in elderly bone and gastrointestinal homeostasis. Fecal microbiota analyses revealed that the relative abundances of Bacteroides massiliensis, Muribaculum sp., or Prevotella denticola were different between conventional microbiota (CM) and anti-inflammatory restricted microbiota (RM). The murine RM was found conditional on mucosa-associated dysbiosis under both, disturbances of interleukin (IL)-17 signaling and exposure to radiation alone. This review discusses the hypothesis that intestinal microbiota induced alterations in DNA repair and expressed transforming growth factor (TGF)-β in the small intestine, thereby impacting bone microstructure and osteoblast dysfunction in silicon ion (1.5 Gy 28Si ions of 850 MeV/u) irradiated mice. Bacterial microbiota compositions influenced therapeutic approaches, correlated with clinical outcomes in radiotherapy and were associated with alterations of the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections during the last global pandemics. In the absence of TGF-β, functional metagenomics, cytokine profiles, bacterial community analyses in human and murine mucosa cells, and inflammatory markers in rat intestines were analyzed. This research finally showed radiation-induced osteolytic damage to correlated with specific features of intestinal bacterial composition, and these relationships were expatiated together with radiation effects on normal tissue cell proliferation.

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Behavioral Therapies and Biofeedback for Anal Incontinence

Berghmans

Bols

Seleme

et al. 2020

Pelvic Floor Disorders

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Longitudinal Study of Intestinal Symptoms and Fecal Continence in Patients With Conformal Radiotherapy for Prostate Cancer

Cited by 7 publications

References 36 publications

Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy

Dose-escalated simultaneous integrated-boost treatment of prostate cancer patients via helical tomotherapy

Radiation Impacts Microbiota Compositions That Activate Transforming Growth Factor-Beta Expression in the Small Intestine

Behavioral Therapies and Biofeedback for Anal Incontinence

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