Longitudinal Study of Liver Transplant Recipients' Quality of Life as a Function of Their Perception of General Health: At Waiting List and at 3, 6, and 12 Months Post-Transplantation

Martín-Rodríguez, Agustín; Fernández-Jiménez, E.; Pérez-San-Gregorio, María Ángeles; Pérez-Bernal, J.; Gómez‐Bravo, Miguel Ángel

doi:10.1016/j.transproceed.2013.10.026

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…Patients most frequently reported problems in the domains ‘pain/discomfort’ and ‘anxiety/depression’. These findings are in line with the results of a longitudinal study in 30 liver transplant recipients showing that these 2 domains contributed to a worse self-perceived health status 1 year after transplantation [ 37 ].…”

Section: Discussionsupporting

confidence: 88%

Long-Term Effectiveness, Safety, and Patient-Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study

et al. 2022

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Background Self-administered subcutaneous hepatitis B immunoglobulin (s.c. HBIg) in combination with nucleos(t)ide analogs (NUCs) has proved to be effective and safe in preventing hepatitis B virus (HBV) reinfection after liver transplantation. Material/Methods This non-interventional, prospective, single-arm, multicenter, international study collected data on long-term effectiveness, safety, patient satisfaction (Treatment Satisfaction Questionnaire for Medication, TSQM-11), and quality of life (EQ-5D questionnaire) in routine practice over a 2-year treatment period. Data analysis was based on 195 adults (82.1% male) transplanted for HBV-related liver diseases and treated with s.c. HBIg with/without NUC(s). Results HBV recurrence (seropositivity of HBV surface antigen and/or HBV DNA) was observed in 7/195 (3.6%) patients (annual rate: 2.01%). Hepatocellular carcinoma (HCC) recurred in 4/83 (4.8%) patients transplanted for HBV-HCC (annual rate: 2.88%). Twenty-nine adverse drug reactions occurred in 16/195 (8.2%) patients. Convenience and overall satisfaction scores of the TSQM-11 were significantly ( P <0.05) improved under treatment at the 3-month, 2-year, and last follow-up visits. Quality of life remained constant over the entire observation period (EQ-5D index [ P ≥0.075]). S.c. HBIg was mainly self-administered (6458/9021 administrations, 71.6%) at home (8514/9021 administrations, 94.4%). Conclusions The results indicate long-term effectiveness and safety of s.c. HBIg in combination with NUC therapy in preventing post-transplant HBV reinfection under real-life conditions. The convenience of the therapy contributed to the high overall treatment satisfaction and acceptance by the patients.

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Section: Discussionsupporting

confidence: 88%

Long-Term Effectiveness, Safety, and Patient-Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study

et al. 2022

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“…In most studies, mental health is reduced in patients on the waiting list 38,39 and improves significantly after OLT. [40][41][42] Nonetheless, there is little evidence as to the influence of liver function on the mental health of these patients. Santos et al found a tendency for high scores of anxiety related to lower MELD scores.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life and affective status in liver transplant recipients and patients on the waiting list with low MELD scores

Benzing

Krezdorn

Förster

et al. 2016

HPB

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“…However, the significant gains in quality of life, which are grounded by improvements in physical health, are counterbalanced by minimal gains in a recipient's psychological functioning (Bravata, Olkin, Barnato, Keeffe, & Owens, 1999). One year after transplant, a liver transplant recipient's perception of their quality of life shifts from a focus on the physical aspects of transplant to their psychological health (Martín‐Rodríguez, Fernández‐Jiménez, Pérez‐San‐Gregorio, Pérez‐Bernal, & Gómez‐Bravo, 2013). Hence, there is need for psychological treatments to react to the evolving needs of liver transplant recipients and enable continued improvements in their quality of life (Onghena et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

An exploratory study of the experiences of deceased‐donor liver transplant recipients and their need for psychotherapeutic support

McKie

Webzell

Tavabie

et al. 2020

Journal of Clinical Nursing

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Aims and objectives:This study aimed to explore the experiences of liver transplant recipients during their journey through the treatment and their need for psychotherapeutic support related to this process.Background: Over time, measures of survival and quality of life in liver transplant recipients have continued to improve but their emotional needs remain under explored. In the longer-term recovery from transplantation, the focus shifts from physical health to psychological health. In the UK, there are no known embedded adult psychological services in liver transplant centres to react to this need.Design: A qualitative descriptive design was used.Methods: Grounded theory analysis was used to study the narratives of six adult liver transplant recipients. Through a process of coding, conceptual categories were established to describe the participant experiences. The study adhered to the EQUATOR checklist, SRQR.Results: Four categories emerged that were related to the experience of liver transplantation for the recipients. These were a process of adjustment, the phenomenon of waiting, liver transplant as a transformative experience and on the value of support. The participants identified a lack of psychotherapeutic support provided by the liver transplant service and felt that an embedded psychotherapeutic service would promote accessing such support during challenging times. Conclusion:Through the process of liver transplantation, recipients experience challenges with adjustment, waiting, feeling transformed and they value support with these feelings. In correlation with other studies, the findings of this study highlight the need for providing psychotherapeutic support within liver transplant services.

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Longitudinal Study of Liver Transplant Recipients' Quality of Life as a Function of Their Perception of General Health: At Waiting List and at 3, 6, and 12 Months Post-Transplantation

Cited by 9 publications

References 4 publications

Long-Term Effectiveness, Safety, and Patient-Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study

Long-Term Effectiveness, Safety, and Patient-Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study

Health-related quality of life and affective status in liver transplant recipients and patients on the waiting list with low MELD scores

An exploratory study of the experiences of deceased‐donor liver transplant recipients and their need for psychotherapeutic support

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