Longitudinal study of serum copper and zinc levels and their distribution in blood proteins after acute myocardial infarction

Gomez, Edward C.; Diego, C. del; Orden, Isabel Visedo; Elósegui, L. M.; Borque, L.; Escanero, J.F.

doi:10.1016/s0946-672x(00)80031-0

Cited by 13 publications

(7 citation statements)

References 26 publications

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“…This may manifest in decreased levels of plasma zinc. Intriguingly, the same conditions that are associated with high FFA levels, including congestive heart failure, myocardial ischemia and infarction, are also known to result in decreased plasma zinc [98,99] -more precisely, exchangeable, albumin-bound zinc [100,101]. This is consistent with the idea that in these conditions, the increased FFA levels lead to lower zinc-binding capacity by albumin, and an increase in free Zn 2+ available for cellular uptake.…”

Section: Potential Impact Of Albumin On Cellular Zinc Homeostasissupporting

confidence: 72%

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Blindauer

Khazaipoul²,

Yu³

et al. 2016

CTMC

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(2016) Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin : implications for cardiovascular disease. Current Trends in Medicinal Chemistry, 16. Permanent WRAP URL:http://wrap.warwick.ac.uk/78963 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way.Publisher's statement: © Bentham Science Publishers. http://dx.doi.org/10.2174/1568026616666160216155927 A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. Abstract: Human serum albumin (HSA) is the major protein in blood plasma and is responsible for circulatory transport of a range of small molecules including fatty acids, metal ions and drugs. We previously identified the major plasma Zn 2+ transport site on HSA and revealed that fatty-acid binding (at a distinct site called the FA2 site) and Zn 2+ binding are interdependent via an allosteric mechanism. Since binding affinities of long-chain fatty acids exceed those of plasma Zn 2+ , this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn 2+ -binding, and hence affects the control of circulatory and cellular Zn 2+ dynamics. This relationship between circulatory fatty acid and Zn 2+ dynamics is likely to have important physiological and pathological implications, especially since it has been recognised that Zn 2+ acts as a signalling agent in many cell types. Fatty acid levels in the blood are dynamic, but most importantly, chronic elevation of plasma fatty acid levels is associated with some metabolic disorders and disease states -including myocardial infarction and other cardiovascular diseases. In this article, we briefly review the metalbinding properties of albumin and highlight the importance of their interplay with fatty acid binding. We also consider the impact of this dynamic link upon levels and speciation of plasma Zn 2+ , its effect upon cellular Zn 2+ homeostasis and its relevance to cardiovascular and circulatory processes in health and disease.

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Section: Potential Impact Of Albumin On Cellular Zinc Homeostasissupporting

confidence: 72%

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Blindauer

Khazaipoul²,

Yu³

et al. 2016

CTMC

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“…Kok et al (1988) show that the adjusted risk of death from cardiovascular disease was about four times higher for subjects in the highest serum Cu quintile compared with those with normal levels, indicating that high serum Cu is associated with the mortality of cardiovascular disease. Although there is not necessarily a direct causeeffect relationship between the development of MI and Cu concentration, it is frequently assumed that Cu is MI risk factor (Gomez et al, 2000;He & James Kang, 2013). Researchers have found that high dietary Cu increased all lipid classes and fatty acid unsaturation (palmitoleic, oleic, linoleic acids), decreased stearic acid in phosphatidylcholine and phosphatidylethanolamine of heart (Jenkins & Kramer, 1989).…”

Section: Introductionmentioning

confidence: 99%

Association between copper levels and myocardial infarction: a meta-analysis

Chen

Lei

2015

Inhalation Toxicology

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“…Trace elements are being increasingly recognized as essential mediators of the development and progression of MI [3,4]. Although there is no necessarily a direct cause-effect relationship between the development of MI and trace elements status, it is generally believed that the disturbances of them, such as zinc (Zn) and copper (Cu), are risk factors for MI [5,6].…”

Section: Introductionmentioning

confidence: 99%

Deficient Zinc Levels and Myocardial Infarction

Liu¹,

Cai

Zhou³

2015

Biol Trace Elem Res

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The purpose of this study is to clarify the association between Zn levels and myocardial infarction (MI) using a meta-analysis approach. We searched articles in the PubMed, OVID, and ScienceDirect published as of November 2014. Thirteen eligible articles with 2886 subjects from 41 case-control studies were identified. Overall, pooled analysis indicated that subjects with MI had lower Zn levels than healthy controls (standardized mean difference (SMD) = -1.848, 95 % confidence interval (CI) = [-2.365, -1.331]). Further subgroup analysis found that subjects with MI had lower Zn levels than healthy controls in serum (SMD = -1.764, 95 % CI = [-2.417, -1.112]) and hair (SMD = -3.326, 95 % CI = [-4.616, -2.036]), but not in toenail (SMD = -0.396, 95 % CI = [-1.114, 0.322]). The subgroup analysis stratified by type of Zn measurement found a similar pattern in inductively coupled plasma-atomic absorption spectrometry (ICP-AAS) (SMD = -2.442, 95 % CI = [-3.092, -1.753]), but not in neutron activation analysis (NAA) (SMD = -0.449, 95 % CI = [-1.127, 0.230]). Lower Zn levels in MI patients were found both in male (SMD = -3.350, 95 % CI = [-4.531, -2.169]) and female (SMD = -2.681, 95 % CI = [-3.440, -1.922]). And the difference of Zn levels according to MI in Asia (SMD = -2.555, 95 % CI = [-3.267, -1.844]) was greater to that among the population in Europe (SMD = -0.745, 95 % CI = [-1.386, -0.104]), but no difference was found in Oceania (SMD = -0.255, 95 % CI = [-0.600, 0.089]). In conclusion, this meta-analysis indicates that there is a significant association between Zn deficiency and MI. We suggest that a community-based, long-term observation in a cohort design should be performed to obtain better understanding of causal relationships between Zn and MI, through measuring hair Zn at baseline to investigate whether the highest zinc category versus lowest was associated with MI risk.

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Longitudinal study of serum copper and zinc levels and their distribution in blood proteins after acute myocardial infarction

Cited by 13 publications

References 26 publications

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease

Association between copper levels and myocardial infarction: a meta-analysis

Deficient Zinc Levels and Myocardial Infarction

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