Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury

Ljungqvist, Johan; Nilsson, Daniel; Ljungberg, Maria; Sörbo, Ann; Esbjörnsson, Eva; Eriksson-Ritzén, Catherine; Skoglund, Thomas

doi:10.3109/02699052.2011.558038

Cited by 51 publications

(31 citation statements)

References 39 publications

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“…Conversely, deterioration of white matter microstructure in the first 6 months after injury has been associated with worse clinical outcome (Ljungqvist et al, 2011). …”

Section: White Matter Injury As a Marker Of Tbi Outcomementioning

confidence: 99%

Traumatic Brain Injury as a Disorder of Brain Connectivity

Hayes

Bigler

Verfaellie

2016

J Int Neuropsychol Soc

202

134

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Objectives Recent advances in neuroimaging methodologies sensitive to axonal injury have made it possible to assess in vivo the extent of traumatic brain injury (TBI) -related disruption in neural structures and their connections. The objective of this paper is to review studies examining connectivity in TBI with an emphasis on structural and functional MRI methods that have proven to be valuable in uncovering neural abnormalities associated with this condition. Methods We review studies that have examined white matter integrity in TBI of varying etiology and levels of severity, and consider how findings at different times post-injury may inform underlying mechanisms of post-injury progression and recovery. Moreover, in light of recent advances in neuroimaging methods to study the functional connectivity among brain regions that form integrated networks, we review TBI studies that use resting-state functional connectivity MRI methodology to examine neural networks disrupted by putative axonal injury. Results The findings suggest that TBI is associated with altered structural and functional connectivity, characterized by decreased integrity of white matter pathways and imbalance and inefficiency of functional networks. These structural and functional alterations are often associated with neurocognitive dysfunction and poor functional outcomes. Conclusions TBI has a negative impact on distributed brain networks that lead to behavioral disturbance.

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“…Conversely, deterioration of white matter microstructure in the first 6 months after injury has been associated with worse clinical outcome (Ljungqvist et al, 2011). …”

Section: White Matter Injury As a Marker Of Tbi Outcomementioning

confidence: 99%

Traumatic Brain Injury as a Disorder of Brain Connectivity

Hayes

Bigler

Verfaellie

2016

J Int Neuropsychol Soc

202

134

View full text Add to dashboard Cite

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“…2 The corpus callosum (CC) is particularly vulnerable to diffuse axonal injury. 3,4,5,6,7 There are conflicting results on the relation between acute injury severity and the persistence of CC injury.…”

Section: Event-related Potential Measure Of Interhemispheric Transfermentioning

confidence: 99%

The UCLA Study of Children with Moderate-to-Severe Traumatic Brain Injury: Event-Related Potential Measure of Interhemispheric Transfer Time

Ellis

Marion

McArthur

et al. 2016

Journal of Neurotrauma

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Traumatic brain injury (TBI) frequently results in diffuse axonal injury and other white matter damage. The corpus callosum (CC) is particularly vulnerable to injury following TBI. Damage to this white matter tract has been associated with impaired neurocognitive functioning in children with TBI. Event-Related Potentials can identify stimulus-locked neural activity with high temporal resolution. They were used in this study to measure interhemispheric transfer time (IHTT) as an indicator of CC integrity in 44 children with moderate/severe TBI at 3-5 months post-injury compared with 39 healthy control children. Neurocognitive performance was also examined in these groups. Nearly half of the children with TBI had IHTTs that were outside the range of the healthy control group children. This subgroup of TBI children with slow IHTT also had significantly poorer neurocognitive functioning than healthy controls-even after correction for premorbid intellectual functioning. We discuss alternative models for the relationship between IHTT and neurocognitive functioning following TBI. Slow IHTT may be a biomarker that identifies children at risk for poor cognitive functioning following moderate/severe TBI.

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“…Longitudinal studies have shown decreased FA in the acute phase and then decreased FA and increased MD in the chronic phase, which is suggestive of axonal injury followed by demyelination or gliosis. 84,85 MacDonald and colleagues described FA reductions in 38 of 63 U.S. military personnel with blast-related mTBI, as well as increased MD on the initial scan in the subacute time frame, then normalized MD on the follow-up scan at 6 to 12 months, which was suggestive of resolved edema and inflammation. 36 This finding does not contradict previously described reports of increased MD from demyelination or gliosis in the chronic time frame, as those studies included patients with moderate and severe TBI.…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

Amyot

Arciniegas

et al. 2015

Journal of Neurotrauma

183

147

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The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in 2009, according to the Centers for Disease Control and Prevention. It is a contributing factor in 30.5% of injury-related deaths among civilians. Additionally, since 2000, more than 260,000 service members were diagnosed with TBI, with the vast majority classified as mild or concussive (76%). The objective assessment of TBI via imaging is a critical research gap, both in the military and civilian communities. In 2011, the Department of Defense (DoD) prepared a congressional report summarizing the effectiveness of seven neuroimaging modalities (computed tomography [CT], magnetic resonance imaging [MRI], transcranial Doppler [TCD], positron emission tomography, single photon emission computed tomography, electrophysiologic techniques [magnetoencephalography and electroencephalography], and functional near-infrared spectroscopy) to assess the spectrum of TBI from concussion to coma. For this report, neuroimaging experts identified the most relevant peer-reviewed publications and assessed the quality of the literature for each of these imaging technique in the clinical and research settings. Although CT, MRI, and TCD were determined to be the most useful modalities in the clinical setting, no single imaging modality proved sufficient for all patients due to the heterogeneity of TBI. All imaging modalities reviewed demonstrated the potential to emerge as part of future clinical care. This paper describes and updates the results of the DoD report and also expands on the use of angiography in patients with TBI.

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Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury

Abstract: The diffusion properties of the corpus callosum correlated with clinical outcome in this longitudinal investigation.

Cited by 51 publications

References 39 publications

Traumatic Brain Injury as a Disorder of Brain Connectivity

Traumatic Brain Injury as a Disorder of Brain Connectivity

The UCLA Study of Children with Moderate-to-Severe Traumatic Brain Injury: Event-Related Potential Measure of Interhemispheric Transfer Time

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

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