Longitudinal trajectories of hippocampal volume in middle to older age community dwelling individuals

Fraser, Megan; Walsh, Erin; Shaw, Marnie; Abhayaratna, Walter P.; Anstey, Kaarin J.; Sachdev, Perminder S.

doi:10.1016/j.neurobiolaging.2020.10.011

Cited by 9 publications

(7 citation statements)

References 79 publications

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“…In comparison to direct measurements from the data, our model-derived ADTs underestimate the volume by approximately 1.1 % to 1.5 % for this age range. However, it should be noted that a similar increase in hippocampus volume for this age range has previously been reported (Fraser et al, 2021).…”

Section: Discussionsupporting

confidence: 86%

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Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM

Arthofer,

Smith,

Douaud

et al. 2023

Preprint

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Anatomical MRI templates of the brain are essential to group-level analyses and image processing pipelines, as they provide a reference space for spatial normalisation. While it has become common for studies to acquire multimodal MRI data, many templates are still limited to one type of modality, usually either scalar or tensor-based. Aligning each modality in isolation does not take full advantage of the available complementary information, such as strong contrast between tissue types in structural images, or axonal organisation in the white matter in diffusion tensor images. Most existing strategies for multimodal template construction either do not use all modalities of interest to inform the template construction process, or do not use them in a unified framework.Here, we present multimodal, cross-sectional templates constructed from UK Biobank data: the OMM-1 template, and age-dependent templates for each year of life between 45 to 81. All templates are fully unbiased to represent the average shape of the populations they were constructed from, and internally consistent through jointly informing the template construction process with T1, T2-FLAIR and DTI data. The OMM-1 template was constructed with a multi-resolution, iterative approach using 240 individuals in the 50-55 year age range. The age-dependent templates were estimated using a Gaussian Process, which describes the change in average brain shape with age in 37,330 individuals.All templates show excellent contrast and alignment within and between modalities. The global brain shape and size is not preconditioned on existing templates, although maximal possible compatibility with MNI-152 space was maintained through rigid alignment. We showed benefits in registration accuracy across two datasets (UK Biobank and HCP), when using the OMM-1 as the template compared with FSL’s MNI-152 template, and found that the use of age-dependent templates further improved accuracy to a small but detectable extent. All templates are publicly available and can be used as a new reference space for uni- or multimodal spatial alignment.

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Section: Discussionsupporting

confidence: 86%

“…where GPs were directly applied to volume measurements. However, for the hippocampus, similar trajectories in volume difference due to the data have been reported in the majority subgroup of the study population in (Fraser et al, 2021).…”

Section: Age-dependent Templatessupporting

confidence: 82%

Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM

Arthofer,

Smith,

Douaud

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It is worth noting that these structural and microstructural longitudinal significant differences are modest in size, the strongest differences in changes observed between the SARS-CoV-2 positive and control groups corresponding to around 2% of mean baseline IDP value (Supplementary Table 1). This additional loss in the infected participants of 0.7% on average across the olfactory-related brain regions -and specifically ranging from 1.3% to 1.8% for the FreeSurfer volume of the parahippocampal/ perirhinal and entorhinal cortex -can be helpfully compared with, for instance, the longitudinal loss per year of ~0.2% (in middle age) to 0.3% (in older age) of hippocampal volume in community-dwelling individuals 29 . Our statistics also represent an average effect; not every infected participant will display brain longitudinal abnormalities.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Douaud

Lee

Alfaro-Almagro

et al. 2022

Nature

1,140

892

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This is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

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“…Latent classes were modelled using a linear link function with the number of waves as the time predictor. The best fitting latent class sets were selected based on the model Akaike information criterion (AIC) [ 37 ], the Bayesian information criterion (BIC) [ 38 ], stable allocation of participants to the classes (> 50% of members of each class with posterior probability > 0.7), and at least 20 participants in each class [ 19 ]. Participants’ characteristic in each class was examined using Wilcoxon signed-rank, or Fisher's exact tests (Supplementary Tables S3 & S4).…”

Section: Methodsmentioning

confidence: 99%

Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences

2023

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Purpose To examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age. Methods Participants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class analysis and hierarchical linear regression models were performed to investigate the association between baseline dietary Mg, Mg trajectories, and brain volumes and WMLs. Associations between baseline Mg, and baseline blood pressure (BP) measures, and baseline Mg, Mg trajectories and BP changes (between baseline and wave 2) were also investigated to assess whether BP mediates the link between Mg intake and brain health. All analyses controlled for health and socio-demographic covariates. Possible interactions between menopausal status and Mg trajectories in predicting brain volumes and WMLs were also investigated. Results On average, higher baseline dietary Mg intake was associated with larger brain volumes (gray matter [GM]: 0.001% [SE = 0.0003]; left hippocampus [LHC]: 0.0013% [SE = 0.0006]; and right hippocampus [RHC]: 0.0023% [SE = 0.0006]) in both men and women. Latent class analysis of Mg intake revealed three classes: “high-decreasing” (men = 3.2%, women = 1.9%), “low-increasing” (men = 1.09%, women = 1.62%), and “stable normal” (men = 95.71%, women = 96.51%). In women, only the “high-decreasing” trajectory was significantly associated with larger brain volumes (GM: 1.17%, [SE = 0.58]; and RHC: 2.79% [SE = 1.11]) compared to the “normal-stable”, the “low-increasing” trajectory was associated with smaller brain volumes (GM: − 1.67%, [SE = 0.30]; white matter [WM]: − 0.85% [SE = 0.42]; LHC: − 2.43% [SE = 0.59]; and RHC: − 1.50% [SE = 0.57]) and larger WMLs (1.6% [SE = 0.53]). Associations between Mg and BP measures were mostly non-significant. Furthermore, the observed neuroprotective effect of higher dietary Mg intake in the “high-decreasing” trajectory appears to be greater in post-menopausal than pre-menopausal women. Conclusions Higher dietary Mg intake is related to better brain health in the general population, and particularly in women.

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Longitudinal trajectories of hippocampal volume in middle to older age community dwelling individuals

Cited by 9 publications

References 79 publications

Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM

Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences

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