Longterm Prognostic Factors after Hepatic Resection for Hepatocellular Carcinoma

Roh, Mu-Jung; Kim, Hong-Jin; Yoon, Sung-Su; Bae, Jung Min; Lee, Dongsik

doi:10.4174/jkss.2009.76.4.225

Cited by 2 publications

(2 citation statements)

References 16 publications

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“… 1 4 HCC recurrence after curative hepatectomy often occurs in the liver (64-86.5%), and extrahepatic recurrences are relatively infrequent. 5 6 7 Extrahepatic recurrences have a worse prognosis, mostly likely from their presentation at multiple sites with aggressive features. Many patients with extrahepatic recurrences are poor candidates for surgical resections.…”

Section: Introductionmentioning

confidence: 99%

Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection

Byeon¹,

Cho²,

Kim³

et al. 2012

Korean J Hepatobiliary Pancreat Surg

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Backgrounds/AimsThis study was designed to compare the recurrence patterns after curative hepatectomy, to compare the prognosis according to the initial site of metastasis, and to investigate the independent predictive factors associated with extrahepatic recurrence in hepatocellular carcinoma (HCC) patients after curative hepatectomy.MethodsFrom January 2000 to July 2009, 307 patients underwent curative hepatectomies for HCC at our institution; 152 patients showed recurrences. Patients were divided into 2 groups according to their initial recurrence site: the intrahepatic recurrence (IHR) group and extrahepatic recurrence (EHR) group. The IHR group was comprised of 111 patients and the EHR group was comprised of 41 patients. The study investigated the preoperative, intraoperative, and postoperative factors related to the recurrence pattern retrospectively and compared the prognoses of the patients.ResultsA five-year survival rate after an initial recurrence was lower in the EHR group (21.5%) than the IHR group (36.3%) (p<0.001). The preoperative alpha-fetoprotein (AFP) level was an independent risk factor for extrahepatic recurrence (p=0.014).ConclusionsPatients with a preoperative AFP level greater than 200 ng/ml have a higher incidence of extrahepatic metastases after a curative resection of HCC. Increased level of preoperative AFP is an indication for a short-term follow up hepatectomy.

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Section: Introductionmentioning

confidence: 99%

Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection

Byeon¹,

Cho²,

Kim³

et al. 2012

Korean J Hepatobiliary Pancreat Surg

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show abstract

“…As the initial clinical symptom of hepatocellular carcinoma (HCC) is not apparent, only a periodic examination makes it possible to be detected in the early stage. When it is detected with symptoms, intensive and extensive treatments are not feasible because of the regression of liver function accompanied by chronic liver disease or liver cirrhosis, 1 2 and even resection is possible, the 5-year survival rate is low owing to recurrence as compared with other solid cancers. 3 4 …”

Section: Introductionmentioning

confidence: 99%

Long-term survival after resection of hepatocellular carcinoma

Kim

Choi

2012

Korean J Hepatobiliary Pancreat Surg

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Backgrounds/AimsAlthough recent advances in surgical techniques and alternative treatment, the long-term survival >5 years after liver resection for hepatocellular carcinoma (HCC) is still unsatisfactory due to the high recurrence rate compared with other solid organ cancers. This study was conducted to analyze long-term survival after HCC resection and to develop an optimal strategy to achieve long-term survival.MethodsA retrospective review was performed for HCC patients who underwent liver resection between 1996 and 2006. The survival rates and prognostic factors were assessed. The clinical and pathological factors of patients who survived more than 5 years were compared with those of patients whose survival was less than 5 years. The clinicopathological features characterizing long-term survivors were also reviewed.ResultsThe overall and disease-free 5-year survival rates of 87 cases were 38.5% and 29.4%, respectively. Twenty-seven of 87 patients survived longer than 5 years after liver resection. The univariate analysis revealed that hepatitis C, the serum aspartate sminotransferase (AST) level, liver cirrhosis, Edmondson-Steiner grade, AJCC stage, and vascular invasion were significant factors for overall survival, and serum AST level, liver cirrhosis, Edmondson-Steiner grade, AJCC stage, and vascular invasion were the affecting factors for disease-free survival. In multivariate analysis, serum AST level, hepatitis C and vascular invasion were related with the overall survival, liver cirrhosis and vascular invasion which were associated with disease-free survival. Vascular invasion, AJCC stage, and the Edmondson-Steiner grade were significant factors in long-term survivors.ConclusionsPatients without liver cirrhosis, vascular invasion and normal liver function, good differentiation and an early stage may be expected to have a long-term survival.

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Longterm Prognostic Factors after Hepatic Resection for Hepatocellular Carcinoma

Cited by 2 publications

References 16 publications

Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection

Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection

Long-term survival after resection of hepatocellular carcinoma

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