Looking for coeliac disease in children with type 1 diabetes mellitus

Porter, Jody A; MacKenzie, Karen E; Darlow, Brian A; Day, Andrew S.

doi:10.1111/jpc.12643

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…However, there has yet to be a consensus regarding the recommended screening tests and the frequency of screening. 16 Studies published during the last few years have demonstrated elevated prevalence rates of CD among individuals with T1DM: 4.4% in the United Kingdom, 3.7% in Israel, 4.8% in Greece, and 6.4% in Germany, and as high as 10.5% in Brazil and 11.1% in India. 17,18 In our study, the frequency of celiac disease in patients with type-1 diabetes mellitus was observed in 8.47% (15/177).…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease and its Association with Socio-Demographic Parameters in Patients with Diabetes Mellitus Type-1

Imran

Qasim²,

Latif³

et al. 2023

PAFMJ

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Objective: To determine the frequency of Celiac disease in patients with Type-1 Diabetes Mellitus (DM) and its association with socio-demographic parameters. Study Design: Cross-sectional study. Place and Duration: Medical Departments of Dr Ruth K. M. Pfau, Civil Hospital, Karachi Pakistan, from Apr to Sep 2019. Methodology: Patients diagnosed with type-1 DM were enrolled in the study. Patients underwent blood testing for Celiac Serology. IgA level greater than 10U/m1 was taken as positive for celiac disease. If IgA levels were low, then Anti-tTG IgG was tested. Results: One hundred seventy-seven patients diagnosed with type-1 diabetes mellitus were included in this study. The average age of patients was 36.39±6.81 years. There were 109(61.58%) males and 68(38.2%) females. The frequency of celiac disease in patients with type-1 DM was observed at 8.47%. The frequency of celiac disease was not statistically significant among different age groups (p=0.644), gender and disease duration (p>0.05). However, celiac disease was more frequent in patients with a family history, but it was not statistically significant (25% vs 7.7%; p=0.086). Conclusion: This study showed a higher frequency of celiac disease in patients with T1DM than in the general population in our country, and the data lend support to recommend regular screening for Celiac disease in all patients with Type-1 DM.

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Section: Discussionmentioning

confidence: 99%

Celiac Disease and its Association with Socio-Demographic Parameters in Patients with Diabetes Mellitus Type-1

Imran

Qasim²,

Latif³

et al. 2023

PAFMJ

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“…The prevalence of CD in general populations varies widely in a global perspective 0.3% to 0.7% in Asia (3), and 1% in the United States and Europe (4). A substantial increase in the prevalence of CD in patients with T1DM with rates of 2.4% to 16.4% was established (5,6). A pooled analysis, based on 26,605 patients with T1DM, found a prevalence of biopsy‐confirmed CD of 6.0% (2).…”

Section: Methodsmentioning

confidence: 99%

Celiac Disease and Diabetes

Weiss

Pinhas‐Hamiel

2017

J. pediatr. gastroenterol. nutr.

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Prevalence studies from around the world have established a substantial increase in the prevalence of celiac disease (CD) in patients with type 1 diabetes mellitus (T1DM). Approximately two-thirds of patients with T1DM and CD are asymptomatic for CD at diagnosis. We aim to provide an up-to-date state-of-the-art summary of the recommendations for serologic testing for CD in patients with T1DM and to clarify the debate on the need for screening and interventions. We searched Medline and Cochrane databases for studies of celiac autoimmunity and biopsy-proven CD in people with T1DM between January 1, 2000 and December 1, 2015. CD was found to be an independent risk factor for micro- and macrovascular complications, as well as for increased morbidity in patients with T1DM. Publications, however, reveal controversy regarding the benefits of a gluten-free diet (GFD) on glycemic control, bone health, and quality of life in individuals with T1DM and asymptomatic CD. A multicenter, prospective randomized controlled trial aimed to investigate this issue is currently ongoing. Until resolution of the pros and cons of screening for CD, and of the benefit versus burden of GFD treatment in T1DM patients with asymptomatic CD, we recommend repeated screening for CD during childhood and adulthood, and treatment with GFD for those with biopsy-proven CD, even if asymptomatic.

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“…The occurrence of CD, which is an immune‐mediated enteropathy characterised by sensitivity to gluten and small‐intestinal inflammation with villous atrophy , is six to ten times higher in type 1 diabetes patients than in the general population . In the last five years, a substantial increase in the prevalence of CD among type 1 diabetes patients, from 2% to 16%, has been demonstrated . The clinical picture of CD is diverse, ranging from asymptomatic to severe malabsorption and failure to thrive .…”

Section: Introductionmentioning

confidence: 99%

Elevated anti‐tissue transglutaminase antibodies in children newly diagnosed with type 1 diabetes do not always indicate coeliac disease

et al. 2018

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Looking for coeliac disease in children with type 1 diabetes mellitus

Abstract: Most clinicians in NZ screen for CD, but there is a wide variation in practice.

Cited by 7 publications

References 40 publications

Celiac Disease and its Association with Socio-Demographic Parameters in Patients with Diabetes Mellitus Type-1

Celiac Disease and its Association with Socio-Demographic Parameters in Patients with Diabetes Mellitus Type-1

Celiac Disease and Diabetes

Elevated anti‐tissue transglutaminase antibodies in children newly diagnosed with type 1 diabetes do not always indicate coeliac disease

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