Loperamide induces excessive accumulation of bile acids in the liver of mice with different diets

Lei, Zili; Rong, Hedong; Yang, Yanhong; Yu, Siping; Zhang, Tianle; Chen, Lei; Nie, Ya; Song, Qi; Hu, Qing; Guo, Jiao

doi:10.1016/j.tox.2022.153278

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…For bile acid biosynthesis, lysosomal acid lipase (LIPA) has major roles in hydrolyzing CEs to cholesterol in the endocytic compartment [ 116 ], while cholesterol 7α-hydroxylase (CYP7A1), a rate-limiting enzyme of bile acid biosynthesis, contributes to catalyze the hydroxylation of cholesterol [ 117 ]. The ABCC2 generally serves as a transporter for exporting bile acids from hepatocytes to bile [ 118 ]. The expression patterns of these LW-enriched genes illustrated high efficiency in bile acid biosynthesis and secretion in the LW breed.…”

Section: Resultsmentioning

confidence: 99%

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

Sun,

Xie,

Wang

et al. 2024

Microbiome

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Background Domesticated pigs serve as an ideal animal model for biomedical research and also provide the majority of meat for human consumption in China. Porcine intramuscular fat content associates with human health and diseases and is essential in pork quality. The molecular mechanisms controlling lipid metabolism and intramuscular fat accretion across tissues in pigs, and how these changes in response to pig breeds, remain largely unknown. Results We surveyed the tissue-resident cell types of the porcine jejunum, colon, liver, and longissimus dorsi muscle between Lantang and Landrace breeds by single-cell RNA sequencing. Combining lipidomics and metagenomics approaches, we also characterized gene signatures and determined key discriminating markers of lipid digestibility, absorption, conversion, and deposition across tissues in two pig breeds. In Landrace, lean-meat swine mainly exhibited breed-specific advantages in lipid absorption and oxidation for energy supply in small and large intestinal epitheliums, nascent high-density lipoprotein synthesis for reverse cholesterol transport in enterocytes and hepatocytes, bile acid formation, and secretion for fat emulsification in hepatocytes, as well as intestinal-microbiota gene expression involved in lipid accumulation product. In Lantang, obese-meat swine showed a higher synthesis capacity of chylomicrons responsible for high serum triacylglycerol levels in small intestinal epitheliums, the predominant characteristics of lipid absorption in muscle tissue, and greater intramuscular adipcytogenesis potentials from muscular fibro-adipogenic progenitor subpopulation. Conclusions The findings enhanced our understanding of the cellular biology of lipid metabolism and opened new avenues to improve animal production and human diseases.

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Section: Resultsmentioning

confidence: 99%

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

Sun,

Xie,

Wang

et al. 2024

Microbiome

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“…Lei et al suggested that the administration of LOP would induce excessive accumulation of bile acids in the liver. 34 In a separate study, after the administration of LOP, seven patients with bile acid malabsorption exhibited a normal 75 SeHCAT retention value. 35 In our study, the injection of LOP induced decreased serum TBA levels in the mice of the MC group.…”

Section: Food and Functionmentioning

confidence: 93%

The regulatory effects of fucoidan and laminarin on functional dyspepsia mice induced by loperamide

Liu¹,

Zhang²,

Ismail³

et al. 2023

Food Funct.

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Diallyl disulfide alleviates hepatic steatosis by the conservative mechanism from fish to tetrapod: Augment Mfn2/Atgl-Mediated lipid droplet-mitochondria coupling

Wang,

Lai,

Luo

et al. 2024

Redox Biology

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Loperamide induces excessive accumulation of bile acids in the liver of mice with different diets

Cited by 4 publications

References 68 publications

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

The regulatory effects of fucoidan and laminarin on functional dyspepsia mice induced by loperamide

Diallyl disulfide alleviates hepatic steatosis by the conservative mechanism from fish to tetrapod: Augment Mfn2/Atgl-Mediated lipid droplet-mitochondria coupling

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