Lornoxicam, a new potent NSAID with an improved tolerability
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Radhofer-Welte, S; Rabasseda, Xavier

doi:10.1358/dot.2000.36.1.566627

Cited by 77 publications

(62 citation statements)

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“…19 Lornoxicam is a potent new NSAID of the oxicam class. 3,4 Previous studies with lornoxicam 8 mg have shown it to be as effective as meperidine 50 mg 5 or tramadol 50 mg 20 after various surgical procedures. In another study, Trampitsch et al 21 determined that lornoxicam administered preemptively appears to improve the quality of postoperative analgesia, and leads to reduced consumption of opioid analgesics postoperatively in patients undergoing gynecological operations.…”

Section: Discussionmentioning

confidence: 99%

“…5 The most frequent adverse effects were dizziness, abdominal pain, headache, and vomiting. [3][4][5] Postoperative nausea and vomiting after thyroid surgery is especially common, with previous studies reporting a rate of 51% to 76%. [30][31][32] Similarly in our study, the most common adverse effect in the study groups were PONV, and we determined a decrease in adverse effects associated with opioid consumption in the combination group, demonstrating that a multimodal analgesic approach using adjunctive drugs reduces the need for opioid analgesic and decreases adverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Lornoxicam is a potent new NSAID of the oxicam class that has been shown to be effective and well tolerated in the treatment of postoperative pain. [3][4][5] The short plasma half-life (three to five hours) of lornoxicam may provide advantages over other NSAIDs. 4 Wound infiltration with local anesthetics is an alternative and acceptable method for the management of postoperative pain.…”

Section: Conclusion : L'infiltration Dans Le Site D'incision Avec Unementioning

confidence: 99%

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Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Karamanlıoğlu

Turan

Memiş

et al. 2005

Can J Anesth/J Can Anesth

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Purpose:To compare efficacy and patient outcome of wound infiltration with ropivacaine, lornoxicam, or their combination for control of pain following thyroid surgery. Methods:Eighty patients underwent thyroid surgery were randomly assigned to one of four groups. Before skin closure, local tissues were infiltrated with 12 mL saline in Group S, with 10 mL of ropivacaine 0.75% plus 2 mL saline in Group R, with 2 mL of lornoxicam (8 mg) plus 10 mL saline in Group L, and with 10 mL ropivacaine 0.75% plus 2 mL lornoxicam (8 mg) in Group RL. Pain scores, total and incremental meperidine consumption were recorded at 30 min, one, two, three, four, six, eight, 12, 18, and 24 hr postoperatively. Time to first analgesic requirement, patient satisfaction, and duration of hospital stay were also compared after surgery. Results:The pain scores in Group RL were significantly lower in the first 12 hr than in Group S, and in the first four hours than in Groups R and L (P < 0.01). The time to first analgesic requirement was significantly longer (14.8 ± 8.4 hr vs 5.9 ± 5.2 hr; P < 0.01), the total pethidine consumption was significantly less than Group S (34.0 ± 33.0 mg vs 78.0 ± 29.8 mg; P<0.001), return of gastrointestinal function, ambulation time, length of hospital stay (P < 0.05) were significantly shorter, and patient satisfaction (P < 0.01) was significantly better in Group RL than in Group S (P < 0.05). Conclusion: Wound infiltration with ropivacaine 0.75% plus lornoxicam 8 mg combination improved postoperative pain control and patient comfort, and decreased the need for opioids than the use of either drug alone. (14,8 ± 8,4 h vs 5,9 ± 5,2 h ; P < 0,01), la consommation totale de péthidine a été plus basse que dans le groupe S (34,0 ± 33,0 mg vs 78,0 ± 29,8 mg ; P < 0,001) Objectif

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Conclusion : L'infiltration Dans Le Site D'incision Avec Unementioning

confidence: 99%

See 1 more Smart Citation

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Karamanlıoğlu

Turan

Memiş

et al. 2005

Can J Anesth/J Can Anesth

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“…Its analgesic activity is comparable to that of opioids. High therapeutic potency is indicated in low doses, with a reduced risk of side eff ects (6)(7)(8). Preliminary research, which requires further confi rmation, suggest that lornoxicam may be a better alternative or adjunctive therapy to opioid analgesics in the treatment of moderate to severe pain (9,10).…”

Section: Research Articlementioning

confidence: 99%

The synergistic antinociceptive effect of lornoxicam in combination with tramadol

Saračević

Bečić

2013

JHSCI

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Introduction:One of the most important priorities in therapy is pain control. Therefore, many different groups of drugs are being used for this purpose, primarily opioid analgesics and non-steroidal anti-infl ammatory drugs (NSAIDs). Opioid analgesic tramadol, by binding to specifi c receptors, modulates the perception and response to painful stimuli and inhibits transmitting and further processing of pain impulses. Lornoxicam, which belongs to the oxicam class of NSAIDs, is a non-selective cyclooxygenase inhibitor with strong analgesic and anti-infl ammatory effects, and better tolerance profi le. Preliminary research, which requires further verifi cation, suggests that lornoxicam may be a better alternative or adjunctive therapy to opioid analgesics in the treatment of moderate to severe pain. The aim of this study was to investigate antinociceptive effects of lornoxicam, as well as the combination of lornoxicam with tramadol.Methods: Analgesic effect of combination of lornoxicam and tramadol or lornoxicam applied alone was examined on female albino mice, using a hot plate method. Measurements were made 30, 60, 90 and 120 minutes after intraperitoneal and subcutaneous administration, in dose of 10 mg/kg. Results:Combination of lornoxicam and tramadol, applied intraperitoneally, increases the threshold of sensitivity to painful stimuli, which was not the case with subcutaneous administration. Conclusions:Lornoxicam signifi cantly increases analgesic effect when applied intraperitoneally in combination with tramadol. On the other hand, lornoxicam in combination with tramadol, did not increase the threshold of sensitivity to painful stimuli with signifi cant difference, after subcutaneous administration.

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“…The plasma half-life is longer than other oxicams, and for this reason, it has fewer adverse effects [7]. In experimental studies, it has been shown that lornoxicam plays a role in decreasing hypersensitivity by causing antinociception via spinal COX inhibition [8].…”

Section: Introductionmentioning

confidence: 99%

Comparing Early Postoperative Period Analgesic Effect of Dexketoprofene Trometamol and Lornoxicam in Mediastinoscopy Cases

Sagiroglu

2011

EAJM

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Objective: In this study, we aimed comparing early postoperative period analgesic effectiveness and the effects on opioid consumption of intravenous dexketoprofen and lornoxicam that are given preemptively. Materials and Methods:Forty patients, planned elective mediastinoscopy, were included in this prospective randomized study. These patients were classified in two groups, group D for dexketoprofene trometamol and group L for lornoxicam, randomly. 20 minutes before the operation 50 mg dexketoprofene trometamol and 8 mg lornoxicam were injected intravenously for group D and group L respectively. In postoperative intensive care unit, pain scores, mean arterial pressures, heart rates and peripheric O2 saturations of patients were recorded at 0, 10, 20, 60, 90 and 120 th minutes.Results: When we evaluate the VAS score of the groups, there was a significant decrease in group D in all measured timesstatistically compairing to group L (p<0.001). When both group were evaluated in itself according to 0 minute time, in group L there was a significant decrease at 10 minutes time (p<0.0001) but in group D there was not a significant decrease (p>0.05). Conclusion:Since intravenous dexketoprofen, applied preemptively, has more potent analgesic effect and causing less opioid consumption in early postoperative period, is better than intravenous lornoxicam. Sonuç: Preemptif uygulanan intravenöz deksketoprofen, erken postoperatif dönemdeki analjezik etkinliği ve daha az opioid tüketimi ile IV lornoksikam'dan üstündür.

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Lornoxicam, a new potent NSAID with an improved tolerability profile

Cited by 77 publications

References 0 publications

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption

The synergistic antinociceptive effect of lornoxicam in combination with tramadol

Comparing Early Postoperative Period Analgesic Effect of Dexketoprofene Trometamol and Lornoxicam in Mediastinoscopy Cases

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