The phenomenon of home advantage (or home bias) is well-analyzed in the scientific literature and is traditionally an interdisciplinary topic. Current theorizing views the fans as a crucial factor influencing the outcome of a football (a.k.a. soccer) game, as the crowd influences the behavior of the players and officials involved in the game through social pressure. So far, the phenomenon has been difficult to study because, although there have always been single matches where the spectators were excluded, this never happened globally to all teams within a league or even across leagues. From an empirical perspective, the situation with COVID-19 governmental measures, especially the ban of fans from stadiums all over the world, can be interpreted as a “natural experiment” and analyzed accordingly. Thus, several studies examined the influence of supporters by comparing matches before the COVID-19 restrictions with so-called ghost games during the pandemic. To synthesize the existing knowledge after over a year of ghost games and to offer the scientific community and other stakeholders an overview regarding the numerous studies, we provide a systematic literature review that summarizes the main findings of empirical studies and discusses the results accordingly. Our findings - based on 16 studies - indicate that ghost games have a considerable impact on the phenomenon of home advantage. No study found an increased home advantage in ghost games. Rather, our results show that 13 (from 16 included) analyzed studies conclude – based on their individually analyzed data – a more or less significant decrease of home advantage in ghost games. We conclude that our findings are highly relevant from a both socio-economic and behavioral perspective and highlight the indirect and direct influence of spectators and fans on football. Our results have – besides for the scientific community – a high importance for sports and team managers, media executives, fan representatives and other responsible.