1983
DOI: 10.1038/bjc.1983.38
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Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues

Abstract: Summary The presence of succinyl-coenzyme A: acetoacetate CoA-transferase (3-oxo acid-CoA transferase), an initiator of ketone body utilization in non-hepatic tissue was examined in a number of animal and human tumours of peripheral tissues. While enzyme levels in heart, kidney, lymphocytes and bladder were high, the tumours contained low or non-detectable levels of transferase activity, comparable with that of normal liver. The activities of acetoacetyl-CoA thiolase paralleled that of the transferase, except … Show more

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Cited by 90 publications
(69 citation statements)
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“…However, no activity of the enzyme 3-ketoacid CoA transferase was detected. A similar distribution of enzyme activities has been reported for other tumours of the peripheral tissues (Tisdale & Brennan, 1983). Since activity of the enzyme 3-ketoacid CoA transferase determines the extent to which 3-hydroxybutyrate is used as a metabolic fuel (Williamson et al, 1971) it might be expected that the Walker 256 carcinosarcoma would be unable to metabolize ketone bodies.…”
Section: Discussionmentioning
confidence: 68%
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“…However, no activity of the enzyme 3-ketoacid CoA transferase was detected. A similar distribution of enzyme activities has been reported for other tumours of the peripheral tissues (Tisdale & Brennan, 1983). Since activity of the enzyme 3-ketoacid CoA transferase determines the extent to which 3-hydroxybutyrate is used as a metabolic fuel (Williamson et al, 1971) it might be expected that the Walker 256 carcinosarcoma would be unable to metabolize ketone bodies.…”
Section: Discussionmentioning
confidence: 68%
“…Determination of tumour enzyme activities The activities of 3-hydroxybutyrate dehydrogenase, acetyl CoA acetyltransferase and 3-ketoacid CoA transferase were determined spectrophotometrically as described previously (Tisdale & Brennan, 1983 Food intakes were measured daily and all animals had attained a stable food intake by the seventh day. On the eighth day, total body nitrogen was determined by neutron activation analysis in vivo and this was followed by either tumour implantation (Groups A, B, C) or sham operation (Group D).…”
Section: Animalsmentioning
confidence: 99%
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“…It is clear that the wasting seen in association with cancer is different from uncomplicated starvation (Stein, 1978;Conyers et al, 1979a,b;Magee et al, 1979;Brennan, 1981) but little is known about the role of ketone bodies in this state. The host's ability to become ketonaemic may well influence his survival in terms of energy conservation, as in uncomplicated starvation, and decreased tumour progression due to either the inability of tumours to use ketone bodies as fuels or the inhibitory effects of ketone bodies on malignant cell growth (Conyers et al, 1979a;Magee et al, 1979;Tisdale & Brennan, 1983).…”
mentioning
confidence: 99%
“…Ketone bodies might be expected to preserve lean body mass during periods of weight loss and to be poor metabolic substrates for the tumour (Tisdale & Brennan, 1983;Rofe et al, 1986). Additional rationalization for the use of a ketogenic diet for the reversal of the weight loss in cancer cachexia has come from recent studies showing inhibition of lipolytic and proteolytic factors produced by the MAC16 tumour by sodium D-(-)3-hydroxybutyrate (Beck & Tisdale, 1987).…”
Section: Discussionmentioning
confidence: 99%