Loss of basal cell keratin 14 reflects increased risk of recurrence in surgically resected sinonasal inverted papilloma

Gunia, Sven; Liebe, D.; Koch, Stefan

doi:10.1136/jcp.2008.055954

Cited by 15 publications

(11 citation statements)

References 23 publications

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“…This parameter was also significantly higher in sinonasal IP group in comparison with controls. Similarly to our study, other authors also demonstrated higher immunoexpression of Ki67 in squamous cell carcinoma and nasal IPs with dysplasia, suggesting that a high proliferative rate is a characteristic of IP-associated malignant diseases [43][44][45][46][47]. Kawasaki et al [47] postulated survivin as the strongest apoptosis inhibitory factor, involved in the regulation of cellular proliferation in colon cancer.…”

Section: Discussionsupporting

confidence: 64%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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Abstract:The immunoexpression of the inhibitor of apoptosis protein survivin has been shown to be a significant prognostic factor in various human cancers. Immunohistochemical method was used to examine the expression of survivin, Ki67 and Bcl-2 in 20 cases of sinonasal inverted papillomas (IPs), 12 cases of sinonasal squamous cell carcinoma (SNCs) and 19 cases of nasal chronic sinusitis as a control. Nuclear immunostaining for survivin was observed in 14 of 20 (70%) cases of sinonasal IPs and 10 of 12 (83.4%) cases of SNCs. Apart from nuclear, also weak cytoplasmic immunoexpression of survivin was detected in 2 of 20 cases (10%) of sinonasal IP and moderate intense staining in 9 of 12 cases (75%) of SNC. There was no immunostaining for survivin in 19 control cases. The immunoexpression of survivin, Ki67 and Bcl-2 was significantly higher in SNCs than in sinonasal IPs and control group. Moreover, nuclear survivin and Ki67 antigen immunoexpression were significantly higher in sinonasal IPs group as compared to control group. There were statistically significant positive correlations between nuclear (but not cytoplasmic) immunoexpression of survivin and Ki67 antigen, as well as Bcl-2 oncoprotein in both tested tumors. In conclusion, our findings suggest that survivin, Ki67 and Bcl-2 may be involved in sinonasal tumorigenesis.

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Section: Discussionsupporting

confidence: 64%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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“…6 33 The basal and suprabasal cells of IPs are immunoreactive for CK5, CK14 and CK17 33. It has been suggested that decreased expression of CK14 is associated with an increased risk of local recurrences (fig 4F); however this assertion needs independent confirmation 34…”

Section: Schneiderian Papillomasmentioning

confidence: 98%

Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx

Perez-Ordoñez

2009

J Clin Pathol

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Lesions of the sinonasal tract are uncommon, with most of the specimens seen by surgical pathologists consisting primarily of fragments of inflamed sinonasal mucosa or inflammatory polyps from patients with chronic rhinosinusitis, and the occasional squamous cell carcinoma. Other lesions such as hamartomas, various types of Schneiderian papillomas and adenocarcinomas are seen only rarely by most histopathologists; therefore a biopsy or surgical resection specimen from a patient with one of these processes may represent a diagnostic challenge. The aim of this review is to present the pathological features of a group of infrequent epithelial surface and glandular lesions of the sinonasal tract which includes respiratory epithelial adenomatoid hamartoma, glandular (seromucinous) hamartoma, exophytic papilloma, inverted papilloma, cylindrical cell (oncocytic) papilloma, low-grade sinonasal adenocarcinoma and intestinal-type sinonasal adenocarcinoma.

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“…IP contains a significantly higher cell population with proliferative activity by comparison with normal sinonasal and inflammatory polyp epithelia, showing a significant correlation between Topoisomerase II-alpha (topoII-alpha) and Ki67 expression, and indicating that topoII-alpha could be a independent prognostic factor for a putative malignant transformation [176, 177]. Immunohistochemical staining of inverted sinonasal papillomas for p53 [115, 175, 178–187] and Ki67 can give useful information concerning the existence of synchronous carcinoma [173, 188] and, in case of high Ki67, a hint toward possible recurrence [136, 177, 189, 190, 190–193]. A study demonstrated ectopic production of beta-human chorionic gonadotropin in cases of inverted papilloma of the nose [194].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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Loss of basal cell keratin 14 reflects increased risk of recurrence in surgically resected sinonasal inverted papilloma

Cited by 15 publications

References 23 publications

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx

Skull Base Inverted Papilloma: A Comprehensive Review

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