Loss of Cellular Cohesion in Cytology Composes a Special Subgroup of Breast Tumors - Analysis of 37 Cases

Wakasa, T.; Nakamura, Misa; Kagiya, Tomoko; Taniguchi, Emiko; Sakurai, Takeo; Kakudo, Kennichi

doi:10.1159/000356405

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Many studies had described the cytological criteria's to diagnose medullary, medullary-like, and metaplastic carcinoma,[26] but in current study, we observed only few cases of above said malignancies; hence data were found to be insufficient for detail morphological studies of these malignancies.…”

Section: Discussioncontrasting

confidence: 59%

Clinical and cyto-morphological characterization of triple negative breast cancer

Kala¹,

Athar

Kala

et al. 2019

J Cytol

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Objective:Triple negative breast cancer (TNBC), despite being the uncommon subtype, contributes a major portion to mortality and associated with poor prognosis. The purpose of this study was to evaluate the cytological criteria for the diagnosis of TNBC through fine-needle aspiration cytology (FNAC).Material and Method:Clinical, cytological, histological, and immunohistochemical (IHC) data of 256 patients were evaluated, and patient were classified as TNBC and non-TNBC phenotype by IHC. All cytological specimens were reviewed for 12 criteria: cellularity, tubule/gland formation, syncytial clusters, large bare nuclei, nuclear atypia, chromatin pattern, cell borders, nucleolus, cytoplasm, lymphocytic infiltrate, calcification, and necrosis. The Fischer's exact test was used to show test association.Result:Out of 256 patients, 82 patients were TNBC, and 174 patients were non-TNBC. TNBC phenotype showed statistically significant association to cellularity, tubule/gland formation, syncytial cluster formation, bare nuclei, nuclear atypia, cell borders, lymphocyte infiltration, and necrosis.Conclusion:FNAC can be helpful in making diagnosis of TNBC and along with ER, PR, HER2 characterization, helpful in planning treatment strategy, saving time, manpower, and resources in the patient management.

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Section: Discussioncontrasting

confidence: 59%

Clinical and cyto-morphological characterization of triple negative breast cancer

Kala¹,

Athar

Kala

et al. 2019

J Cytol

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“…Wakasa et al [35] described a cytological subclassification for breast cytology that showed loss of cellular cohesion; for invasive lobular carcinoma, medullary carcinoma, neuroendocrine carcinoma, and solid papillary carcinoma, this criterion was present in most cases. However, cellular cohesion was not studied for the luminal phenotype of breast carcinoma yet.…”

Section: Discussionmentioning

confidence: 99%

Cytological Criteria for Predicting the Luminal Phenotype of Breast Carcinoma

Paschoalini

Düfloth²,

Neto³

et al. 2016

Acta Cytologica

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Background: Specific cytological criteria for the luminal phenotype of breast carcinoma, despite it being the most common and having a better prognosis as well as targeted therapies under study, remain to be established. Using fine-needle aspiration cytology (FNAC), we aimed to identify the luminal phenotype through the evaluation of cytological criteria recognized in routine practice. Methods: We correlated 169 FNACs of breast carcinomas with their tissue specimens, classified into phenotypes by immunohistochemistry (applying tissue microarray technology) as luminal A, luminal B, HER2 overexpression, and triple negative. All FNAC samples were blindly reviewed according to cellularity, cell cohesion, necrosis, nucleoli, and nuclear atypia. Fisher's exact test was used to test associations between the cytological criteria and phenotypes. Results: The following phenotypes were obtained - luminal A: 107 (63.3%), luminal B: 39 (23.1%), HER2 overexpression: 8 (4.7%), and triple negative: 15 (8.9%). The luminal phenotype showed mild/moderate cellularity (40.4%) (OR = 7.12, 95% CI: 1.61-31.52), inconspicuous, present nucleoli (55.5%) (OR = 8.31, 95% CI: 2.36-29.19), and mild/moderate nuclear atypia (44.5%) (OR = 8.42, 95% CI: 1.90-37.25). Conclusion: The criteria that might indicate the luminal phenotype of breast carcinoma in FNAC were mild/moderate cellularity, inconspicuous, present, and nonprominent nucleoli, and mild/moderate nuclear atypia.

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