Loss of expression of the Neural Cell Adhesion Molecule 1 (NCAM1) in atypical teratoid/rhabdoid tumors: a new diagnostic marker?

Suzuki, Mario; Patel, Kashyap; Huang, Chiang-Ching; Costa, Felipe D’Almeida; Kondo, Akihide; Soares, Fernando Augusto; Tomita, Tadanori

doi:10.1186/s41241-017-0025-9

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Meanwhile, we found that a significant copy number deletion and reduced mRNA expression of NCAM1 in most patients with the Mix_Sub subtype and the reduction in NCAM1 expression appears to be the result of the cis-regulatory effect of genomic copy number changes on transcriptome expression (Figure 7F). We also identified a mechanism of interaction between NCAM1 and FGFR1, as depicted in Figure 7H (30,(32)(33)(34)(35)(36)(37). Overall, our analysis suggests that the low expression of NCAM1 in Mix_Sub subtype patients is likely caused by the large number of copy number deletions, which restrict its binding to FGFR1, resulting in the inability of various downstream signaling pathways to be activated, which in turn led to tumor deterioration and ultimately to poorer survival outcomes for Mix_Sub subtype patients.…”

Section: Mix_sub Subtype Exhibits Distinct Cellcell Communicationsmentioning

confidence: 77%

Integration of multi-omics data reveals a novel hybrid breast cancer subtype and its biomarkers

Wang

Wen

et al. 2023

Front. Oncol.

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Tumor heterogeneity in breast cancer hinders proper diagnosis and treatment, and the identification of molecular subtypes may help enhance the understanding of its heterogeneity. Therefore, we proposed a novel integrated multi-omics approach for breast cancer typing, which led to the identification of a hybrid subtype (Mix_Sub subtype) with a poor survival prognosis. This subtype is characterized by lower levels of the inflammatory response, lower tumor malignancy, lower immune cell infiltration, and higher T-cell dysfunction. Moreover, we found that cell-cell communication mediated by NCAM1-FGFR1 ligand-receptor interaction and cellular functional states, such as cell cycle, DNA damage, and DNA repair, were significantly altered and upregulated in patients with this subtype, and that such patients displayed greater sensitivity to targeted therapies. Subsequently, using differential genes among subtypes as biomarkers, we constructed prognostic risk models and subtype classifiers for the Mix_Sub subtype and validated their generalization ability in external datasets obtained from the GEO database, indicating their potential therapeutic and prognostic significance. These biomarkers also showed significant spatially variable expression in malignant tumor cells. Collectively, the identification of the Mix_Sub breast cancer subtype and its biomarkers, based on the driving relationship between omics, has deepened our understanding of breast cancer heterogeneity and facilitated the development of breast cancer precision therapy.

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Section: Mix_sub Subtype Exhibits Distinct Cellcell Communicationsmentioning

confidence: 77%

Integration of multi-omics data reveals a novel hybrid breast cancer subtype and its biomarkers

Wang

Wen

et al. 2023

Front. Oncol.

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“…PPP1R9A gene overexpression has been detected in prostate cancer [ 29 ] and provides growth advantage to malignant cells. However, the downregulation of NCAM1 genes has been identified in several cancers, suggesting its disrupted repressor function [ 30 ]. It is thus assumed that H. pylori cagA gene integration may be contributory to overall prostate tumorigenesis.…”

Section: Single Species Over Quantity—can Microbiome Directly Stimulate Oncogenesis?mentioning

confidence: 99%

The Role of Microbial Factors in Prostate Cancer Development—An Up-to-Date Review

Garbas

Zapała

et al. 2021

JCM

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Up-to-date studies emphasize the role of human urinary and intestinal microbiome in maintaining urogenital health. Both microbial flora and sexually transmitted pathogens may affect metabolic or immune mechanisms and consequently promote or inhibit prostate carcinogenesis. Hereby, we review the most current evidence regarding the microbial factors and their link to prostate cancer. We conducted a literature search up to December 2020. The microbial impact on prostate cancer initiation and progression is complex. The proposed mechanisms of action include induction of chronic inflammatory microenvironment (Propionibacterium spp., sexually-transmitted pathogens) and direct dysregulation of cell cycle (Helicobacter pylori, Kaposi’s sarcoma-associated herpesvirus- KSHV, human papilloma virus 18- HPV18). Suppression of immune cell expression and downregulating immune-associated genes are also observed (Gardnerella vaginalis). Additionally, the impact of the gut microbiome proved relevant in promoting tumorigenesis (Bacteroides massiliensis). Nevertheless, certain microbes appear to possess anti-tumor properties (Listeria monocytogenes, Pseudomonas spp.), such as triggering a robust immune response and apoptotic cancer cell death. The role of microbial factors in prostate cancer development is an emerging field that merits further studies. In the future, translating microbial research into clinical action may prove helpful in predicting diagnosis and potential outcomes of the disease.

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Anti-tumor potential of high salt in breast Cancer cell lines

Sharma,

Dey,

Das

et al. 2024

Mol Biol Rep

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Loss of expression of the Neural Cell Adhesion Molecule 1 (NCAM1) in atypical teratoid/rhabdoid tumors: a new diagnostic marker?

Cited by 4 publications

References 28 publications

Integration of multi-omics data reveals a novel hybrid breast cancer subtype and its biomarkers

Integration of multi-omics data reveals a novel hybrid breast cancer subtype and its biomarkers

The Role of Microbial Factors in Prostate Cancer Development—An Up-to-Date Review

Anti-tumor potential of high salt in breast Cancer cell lines

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