Loss‐of‐function of <i>Arabidopsis</i> receptor‐like kinase <scp>BIR</scp>1 activates cell death and defense responses mediated by <scp>BAK</scp>1 and <scp>SOBIR</scp>1

Liu, Yanan; Huang, Xiuzhen; Meng, Lingjun; He, Ping; Zhang, Yuelin

doi:10.1111/nph.14072

Cited by 91 publications

(122 citation statements)

References 36 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…The proteins from these networks were activated, indicating an increase in the ABA response in cassava leaves under stress treatments, which is consistent with our results in Table 2 . Previous work showed that BIR1 functions as a negative regulator of plant immunity through regulating multiple plant resistance signaling pathways (Liu et al, 2016). MGT3 was involved in transporting magnesium, which acted as a key osmoticum maintaining growth in low calcium concentrations in plants (Conn et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

Global Gene Expression Analysis Reveals Crosstalk between Response Mechanisms to Cold and Drought Stresses in Cassava Seedlings

Cheng

et al. 2017

Front. Plant Sci.

View full text Add to dashboard Cite

Abiotic stress negatively impacts cassava (Manihot esculenta) growth and yield. Several molecular mechanisms of plant response to cold and drought have been identified and described in the literature, however, little is known about the crosstalk of the responses of cassava to these two stresses. To elucidate this question, transcriptome analysis of cassava seedlings under cold or PEG-simulated drought stress treatment was performed. Our results showed that 6103 and 7462 transcripts were significantly regulated by cold and drought stress, respectively. Gene Ontology annotation revealed that the abscisic and jasmonic acid signaling pathways shared between the two stresses responses. We further identified 2434 common differentially expressed genes (DEGs), including 1130 up-regulated and 841 down-regulated DEGs by the two stresses. These co-induced or co-suppressed genes are grouped as stress signal perception and transduction, transcription factors (TFs), metabolism as well as transport facilitation according to the function annotation. Furthermore, a large proportion of well characterized protein kinases, TF families and ubiquitin proteasome system related genes, such as RLKs, MAPKs, AP2/ERFBPs, WRKYs, MYBs, E2 enzymes and E3 ligases, including three complexes of interacting proteins were shown as key points of crosstalk between cold and drought stress signaling transduction pathways in a hierarchical manner. Our research provides valuable information and new insights for genetically improving the tolerance of crops to multiple abiotic stresses.

show abstract

Section: Resultsmentioning

confidence: 99%

Global Gene Expression Analysis Reveals Crosstalk between Response Mechanisms to Cold and Drought Stresses in Cassava Seedlings

Cheng

et al. 2017

Front. Plant Sci.

View full text Add to dashboard Cite

show abstract

“…BIR1 interacts constitutively with BAK1 but not with other RKs 288 such as FLS2, PEPR1 and CLAVATA and plays a role in cell death control but not in 289 BR or MAMP signaling (Gao et al, 2009;Liu et al, 2016). BIR2 also constitutively 290 interacts with BAK1 and is released after ligand binding to BAK1-interacting RKs, 291 allowing for the interaction of BAK1 with the ligand-bound RKs.…”

Section: Botrytis-induced Kinase1 (Bik1) Which In Turn Phosphorylatementioning

confidence: 99%

The Arabidopsis Leucine-Rich Repeat Receptor Kinase BIR3 Negatively Regulates BAK1 Receptor Complex Formation and Stabilizes BAK1

et al. 2017

View full text Add to dashboard Cite

Short title: BIR3 negatively regulates and stabilizes BAK1One-sentence summary: The receptor kinase BIR3 negatively regulates cell surface receptor complexes and thereby prevents unwanted activation of immune and hormone responses.The authors responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantcell.org) are: Birgit Kemmerling (birgit.kemmerling@zmbp.uni-tuebingen.de) and Xiaofeng Wang (wangxff99@nwsuaf.edu.cn).ABSTRACT BAK1 is a co-receptor and positive regulator of multiple ligand-binding leucine-richrepeat receptor kinases (LRR-RKs) and is involved in brassinosteroid (BR)-dependent growth and development, innate immunity and cell death control. The BAK1-interacting LRR-RKs BIR2 and BIR3 were previously identified by proteomics analyses of in vivo BAK1 complexes. Here we show that BAK1-related pathways such as innate immunity and cell death control are affected by BIR3 in Arabidopsis Plant Cell Advance Publication. Published on August 25 2017, doi:10.1105/tpc.17.00376 ©2017 American Society of Plant Biologists. All Rights Reserved 2 thaliana. BIR3 also has a strong negative impact on BR signaling. BIR3 directly interacts with the BR receptor BRI1 and other ligand-binding receptors and negatively regulates BR signaling by competitive inhibition of BRI1. BIR3 is released from BAK1 and BRI1 after ligand exposure and directly affects the formation of BAK1 complexes with BRI1 or FLAGELLIN SENSING2. Double mutants of bak1 and bir3 show spontaneous cell death and constitutive activation of defense responses. BAK1 and its closest homolog BKK1 interact with and are stabilized by BIR3, suggesting that bak1 bir3 double mutants mimic the spontaneous cell death phenotype observed in bak1 bkk1 mutants via destabilization of BIR3 target proteins. Our results provide evidence for a negative regulatory mechanism for BAK1 receptor complexes in which BIR3 interacts with BAK1 and inhibits ligand-binding receptors to prevent BAK1 receptor complex formation.

show abstract

“…Analysis of suppressor mutants of lsd1 revealed that ADR1, ADR1-L1, and ADR1-L2 are required for the lesion mimic phenotype of lsd1 (Bonardi et al, 2011), suggesting that NB-LRR-mediated defense responses are activated in the mutant. Studies on suppressors of bir1-1 revealed that loss of BIR1 leads to activation of immune responses mediated by RLKs BAK1 and SUPPRESSOR OF BIR1 (SOBIR) 1 (Gao et al, 2009; Liu et al, 2016). …”

Section: Applications Of Autoimmune Mutants In Genetic Analysis Of Plmentioning

confidence: 99%

Mighty Dwarfs: Arabidopsis Autoimmune Mutants and Their Usages in Genetic Dissection of Plant Immunity

2016

Self Cite

View full text Add to dashboard Cite

Plants lack the adaptive immune system possessed by mammals. Instead they rely on innate immunity to defend against pathogen attacks. Genomes of higher plants encode a large number of plant immune receptors belonging to different protein families, which are involved in the detection of pathogens and activation of downstream defense pathways. Plant immunity is tightly controlled to avoid activation of defense responses in the absence of pathogens, as failure to do so can lead to autoimmunity that compromises plant growth and development. Many autoimmune mutants have been reported, most of which are associated with dwarfism and often spontaneous cell death. In this review, we summarize previously reported Arabidopsis autoimmune mutants, categorizing them based on their functional groups. We also discuss how their obvious morphological phenotypes make them ideal tools for epistatic analysis and suppressor screens, and summarize genetic screens that have been carried out in various autoimmune mutant backgrounds.

show abstract

Loss‐of‐function of Arabidopsis receptor‐like kinase BIR1 activates cell death and defense responses mediated by BAK1 and SOBIR1

Cited by 91 publications

References 36 publications

Global Gene Expression Analysis Reveals Crosstalk between Response Mechanisms to Cold and Drought Stresses in Cassava Seedlings

Global Gene Expression Analysis Reveals Crosstalk between Response Mechanisms to Cold and Drought Stresses in Cassava Seedlings

The Arabidopsis Leucine-Rich Repeat Receptor Kinase BIR3 Negatively Regulates BAK1 Receptor Complex Formation and Stabilizes BAK1

Mighty Dwarfs: Arabidopsis Autoimmune Mutants and Their Usages in Genetic Dissection of Plant Immunity

Contact Info

Product

Resources

About