Loss of hereditary uterine protoporphyria through chromosomal rearrangement in mutant Rhode Island Red hens

Schwartz, Samuel; Raux, W.A.; Schacter, Brent; Stephenson, Betty; Shoffner, Robert N.

doi:10.1016/0020-711x(80)90188-3

Cited by 25 publications

(19 citation statements)

References 13 publications

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“…PPIX in most tissues is efficiently converted to heme by FECH (EC 4.99.1.1) in the presence of iron (Dailey, 1977). FECH activity is low in the oviduct of some birds, which allows PPIX to accumulate and serve as a brown pigment on eggshells (Schwartz et al, 1980). Mitoferrin 1 (MFRN1) and ABCB10 are involved in providing iron to mitochondria for heme synthesis (Shaw et al, 2006;Chen et al, 2009).…”

Section: Ppix Biosynthesismentioning

confidence: 99%

Protoporphyrin IX: the Good, the Bad, and the Ugly

Sachar

Anderson

2015

Journal of Pharmacology and Experimental Therapeutics

189

182

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Protoporphyrin IX (PPIX) is ubiquitously present in all living cells in small amounts as a precursor of heme. PPIX has some biologic functions of its own, and PPIX-based strategies have been used for cancer diagnosis and treatment (the good). PPIX serves as the substrate for ferrochelatase, the final enzyme in heme biosynthesis, and its homeostasis is tightly regulated during heme synthesis. Accumulation of PPIX in human porphyrias can cause skin photosensitivity, biliary stones, hepatobiliary damage, and even liver failure (the bad and the ugly). In this work, we review the mechanisms that are associated with the broad aspects of PPIX. Because PPIX is a hydrophobic molecule, its disposition is by hepatic rather than renal excretion. Large amounts of PPIX are toxic to the liver and can cause cholestatic liver injury. Application of PPIX in cancer diagnosis and treatment is based on its photodynamic effects.

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Section: Ppix Biosynthesismentioning

confidence: 99%

Protoporphyrin IX: the Good, the Bad, and the Ugly

Sachar

Anderson

2015

Journal of Pharmacology and Experimental Therapeutics

189

182

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“…Porphyrins were measured using a technique modified from that described by Schwartz et al (1980). A .4-g sample of shell, cleaned of shell membranes, was ground and mixed with .08 g of celite.…”

Section: Color and Porphyrin Concentrationsmentioning

confidence: 99%

Whitening of Brown-Shelled Eggs: Mineral Composition of Uterine Fluid and Rate of Protoporphyrin Deposition

Nys¹,

Zawadzki²,

Gautron³

et al. 1991

Poultry Science

100

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Changes in the mineral composition of uterine fluid during shell formation and the rates of color appearance and porphyrin deposition on the shell were measured in two subpopulations of brown egg-laying hens with familial histories of low or high incidences of shell whitening. Increases in shell weight and shell breaking strength were correlated with, and proportional to, time spent by the egg in the uterus and were similar in both subpopulations. Shell reflectance decreased and the amount of porphyrin deposited increased linearly 20 to 24 h after oviposition of the preceding egg. Porphyrin deposition was slightly higher at the 23-h stage in the high whitening population but similar amounts of porphyrin were deposited on the shell during the final stage of shell formation in both groups. The coating on the shell responsible for whitening was deposited during the hour prior to oviposition. Uterine fluid pH, pCO2, bicarbonate, and ionized Ca concentrations changed during shell formation but these changes were not related to the incidence of whitening. A milieu supersaturated with calcite solubility product was observed whatever the stage of shell formation. Inorganic phosphorus was not detectable in the uterine fluid whatever the stage of shell formation. The soluble phosphorus fraction of uterine decreased 22 h after oviposition and phosphorus deposition on the shell increased. At the end of egg formation uterine fluid could not be collected. It was concluded that shell whitening was associated with changes in the kinetics of porphyrin deposition rather than with changes in the amount of porphyrin deposited or modifications of uterine fluid composition.

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“…Depending on the amount of protoporphyrin, eggshell colour can range from light brown to dark brown. Biliverdin was reported from blue and green eggshells of domesticated fowl (19,32).…”

Section: Introductionmentioning

confidence: 99%

Effect of egg weight and amount of protoporphyrin and biliverdin in the egg shell on hatching characteristics and embryonal mortality in pheasants (Phasianus Colchicus)

DAŞ

2017

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:This study was performed to investigate the effects of egg weight and amount of protoporphyrin and biliverdin in the eggshell on hatchability and embryonic mortality in pheasants. A total of 1908 eggs obtained from 48 weeks old pheasants were used in the study. The eggs were divided into three colour groups (dark brown, light brown and green) and two weight groups (up to 32 g and above 32 g). For the weight groups, there were significant differences in the hatchability of fertile eggs (P<0.01) and late period embryonic mortality (LPEM) (P<0.05). The highest hatchability of fertile eggs and the lowest embryonic mortality were determined in light eggs (≤32 g). In terms of eggshell colour groups, there were significant differences in the hatchability of total eggs (P<0.01); hatchability of fertile eggs (P<0.01); and early (P<0.01), middle (MPEM) (P<0.05) and late period (P<0.05) embryonic mortality. In present study, the highest hatchability and the lowest embryonic mortality rate (except for MPEM) were in the dark brown eggshell group. For all groups, the differences in fertility rate were insignificant (P>0.05). The highest hatching characteristics and the lowest embryonic mortality rates were determined in the dark brown eggs. Based on these results, to achieve higher a hatchability of total eggs, hatchability of fertile eggs and a lower embryonic mortality rate, it may be beneficial selection of dark brown pheasant eggs.Keywords: Biliverdin, egg, hatching characteristics, pheasant, protoporphyrin. Sülünlerde (Phasianus Colchicus) yumurta ağırlığı ve yumurta kabuğundaki protoporfirin ve biliverdin miktarının kuluçka özellikleri ve embriyonal ölüm üzerine etkisiÖzet: Bu araştırma, sülünlerde yumurta ağırlığı ve yumurta kabuğundaki protoporfirin ve biliverdin miktarının kuluçka özellikleri ve embriyonik ölüm üzerine etkisini araştırmak amacıyla yapılmıştır. Araştırmada 48 haftalık sülünlerden elde edilen toplam 1908 yumurta kullanılmıştır. Yumurtalar üç renk grubu (koyu kahve, açık kahve ve yeşil) ve iki ağırlık grubu (≤32 g ve 320.05) bulunmuştur. En yüksek kuluçka performansı, kuluçka oranı ve en düşük embryonik ölüm oranı koyu kahve kabuklu yumurtalarda bulunmuştur. Bu sonuçlara bağlı olarak, daha yüksek bir kuluçka randımanı, çıkım gücü ve daha düşük bir embriyonik ölüm oranı elde etmek için, koyu kahverengi sülün yumurtala...

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Loss of hereditary uterine protoporphyria through chromosomal rearrangement in mutant Rhode Island Red hens

Cited by 25 publications

References 13 publications

Protoporphyrin IX: the Good, the Bad, and the Ugly

Protoporphyrin IX: the Good, the Bad, and the Ugly

Whitening of Brown-Shelled Eggs: Mineral Composition of Uterine Fluid and Rate of Protoporphyrin Deposition

Effect of egg weight and amount of protoporphyrin and biliverdin in the egg shell on hatching characteristics and embryonal mortality in pheasants (Phasianus Colchicus)

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