Loss of Heterozygosity at Chromosome 9p21 in Primary Neuroblastomas: Evidence for Two Deleted Regions

A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer

“…Moulton et al (1995) analysed 27 gliomas, and also suggested that there may be one or more additional tumor suppressor genes on 9p21. Marshall et al (1997) mapped a deleted region in neuroblastoma centromeric of the p16 INK4A gene. Both Puig et al (1995) and Ruiz et al (1998) reported chromosome 9p deletions in cutaneous malignant melanoma outside of the p16 INK4A gene.…”

“…Analyses of primary tumors, however, has shown that not all 9p21 deletions encompass these three tumor suppressor genes. Chromosome 9p deletions outside of the p16 INK4A /p14 ARF and p15 INK4B region have been described in gliomas (Farrell et al, 1997;Marshall et al, 1997), pituitary adenomas (Farrell et al, 1997), lung cancers (Kim et al, 1997;Schmid et al, 1998;Wiest et al, 1997), melanomas (Flores et al, 1996;Ruiz et al, 1998), bladder cancers (Habuchi et al, 1995;Keen and Knowles, 1994), and breast cancers . Hence, it is important to determine if there are other expressed genes on chromosome 9p21 that may be deleted in malignant cells.…”

Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p

“…Several nonrandom genetic events are associated with NB, including allelic losses at chromosomes 1p, 11q, 14q, 9p, 9q, 2q, and 18q, [1][2][3][4][5][6][7] gains at chromosomes 17q, 18q, 1q, 7, and 5q, 8 -11 amplification of the oncogene MYCN, 12 and altered DNA index. 13 MYCN amplification is associated with poor prognosis, but the relationship of other genetic events to the natural history of neuroblastoma has not been firmly established.…”

Chromosome Imbalances and Alterations of AURKA and MYCN Genes in Children with Neuroblastoma

“…Allelic deletions have been detected at multiple genetic loci in 1p, 2q, 3p, 4p, 9p, 11q, 14q, 16p, and 19q for NB (Brodeur et al, 1977;Guo et al, 1999;Fong et al, 1992;Ejeskar et al, 1998;Weiss et al, 2000;Caron et al, 1996;Mora et al, 2001;Marshall et al, 1997). Gilbert and et al (1982) reported that the high frequency of deletions and other rearrangements of 1p were held to be the most common genetic aberration of NB tumour cells.…”