Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas

Schullerus, Dietlinde; Herbers, Jutta; Chudek, Jerzy; Kanamaru, Hiroshi; Kovács, Gyula

doi:10.1002/(sici)1096-9896(199710)183:2<151::aid-path928>3.0.co;2-r

Cited by 99 publications

(36 citation statements)

References 11 publications

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“…8 In addition to DNA alterations on chromosome 3, other chromosomal abnormalities such as losses of chromosome arms 14q, 9p, 8p and 6q have been identified in clear cell renal cell carcinoma, some of which have been shown to have a close correlation with higher stage and a worse outcome. 7,[32][33][34][35][36][37][38][39] It remains unclear whether other chromosomal or gene alterations play a role in the pathogenesis or progression of multilocular cystic renal cell carcinoma. The fact that additional mutations and chromosomal alterations are frequently present in high grade clear cell renal cell carcinomas, but are rarely reported in multilocular renal cell carcinoma, might explain the excellent prognosis of multilocular cystic renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

et al. 2010

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Multilocular cystic renal cell carcinoma is an uncommon low grade renal cell carcinoma with unique morphologic features. Its cytogenetic characteristics have not been fully investigated. Its relationship to typical clear cell renal cell carcinoma is uncertain. We evaluated 19 cases of multilocular cystic renal cell carcinoma diagnosed by strict morphologic criteria using the 2004 WHO classification system. The control group consisted of 19 low grade (Fuhrman grades 1 or 2) clear cell renal cell carcinomas. Chromosome 3p deletion status was determined by dual color interphase fluorescence in situ hybridization analysis. Chromosome 3p deletion was identified in 17 out of 19 (89%) of the clear cell renal cell carcinoma cases and 14 out of 19 (74%) of the multilocular cystic renal cell carcinoma cases, respectively. There was no difference in the status of chromosome 3p deletion between clear cell renal cell carcinoma and multilocular cystic renal cell carcinoma (P ¼ 0.40). These results support the concept that multilocular cystic renal cell carcinoma as a subtype of clear cell renal cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

et al. 2010

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“…2,4 The significant difference in cancer-specific survival between patients with tumors and without 9p losses suggests that a tumor suppressor gene on 9p may be involved in tumor progression. [15][16][17][18] Loss of chromosome 9p was found in 12-36% of clear cell renal cell carcinomas by microsatellite analyses and comparative genomic hybridization. 19 demonstrated an association between loss of heterozygosity on chromosome 9p (24% of cases), using highly polymorphic microsatellite markers, and survival of patient for short duration.…”

Section: Discussionmentioning

confidence: 99%

Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma

et al. 2008

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Loss of chromosome 9p has been implicated in the progression of renal cell carcinoma. We evaluated the clinical utility of fluorescence in situ hybridization analysis of loss of chromosome 9p in 73 patients with clear cell renal cell carcinomas with varied stage, size, grade, necrosis (SSIGN) scores. Loss of chromosome 9p was observed in 13 tumors (18%). The 5-year cancer-specific survival of patients without loss of chromosome 9p was 88% and was 43% in those with loss of chromosome 9p (Po0.001). Local extension of the primary tumor according to the 2002 TNM staging system, lymph node involvement, the presence of distant metastases, and the SSIGN score were the other variables that predicted cancer-specific survival in univariate analysis. Loss of chromosome 9p was an independent prognostic factor in multivariate analysis. Our data indicate that the detection of chromosome 9p loss by fluorescence in situ hybridization analysis of clear cell renal cell carcinoma adds prognostic information beyond the pathological factors included in the current predictive models for renal cell carcinoma, such as SSIGN score.

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“…The relationship of leiomyomatous renal cell carcinoma and clear cell papillary renal cancer based on the presence or absence of VHL mutation and/or 3p losses is currently controversial. Apart from the VHL inactivation as an initiating event in clear cell renal cancer, many different genetic alterations have been reported for this tumor type, some of them associated with prognosis [55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Section: Cytogenetic and Molecular Alterations In Renal Cell Carcinommentioning

confidence: 99%

An overview of renal cell cancer: Pathology and genetics

Moch

2013

Seminars in Cancer Biology

115

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Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas

Cited by 99 publications

References 11 publications

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma

An overview of renal cell cancer: Pathology and genetics

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