Loss of Hla Antigens Associated With Hormonal State

Májský, A; Jakoubková, J

doi:10.1016/s0140-6736(76)91254-x

Cited by 5 publications

(1 citation statement)

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“…of P [17], the patient's HLA antigens were poorly expressed [17]. Since the hormonal levels of the patient were normal, it is tempting to hypothesize that the hard detection of her HLA antigens was due to an increase in the mirror images of 17-OHP [idiotypes of antibody(ies) against the idiotypes of the antibody(ies) anti-17-OHP] originated in an unbalanced autoimmune idiotype net work [18), which can mimic the effects of this steroid without being detectable by the classical methods as 17-OHP itself.…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Js¹,

Sobrinho²,

Mb³

et al. 1990

Dermatology

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We report a case of a 23-year-old woman who was afflicted with disseminated skin erythema multiforme-like eruptions that started at the menarche, relapsed at the premenstrual periods, dramatically spread during two pregnancies and cleared after abortion; the skin lesions responded dramatically to thalidomide treatment. A high-affinity binding factor to 17α-hydroxyprogesterone (17-OHP) was found in the serum of this patient. Her lymphocytes did not proliferate in vitro after exposure to exogenous 17-OHP but showed significant chromatin activation. There was a decreased expression of HLA antigens at the surface of the patient’s blood lymphocytes. This is a unique well-documented case of erythema multiforme most possibly due to autoreactivity to 17-OHP; the precise mechanism(s) of this autoreactivity has not been established.

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Section: Discussionmentioning

confidence: 99%

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Js¹,

Sobrinho²,

Mb³

et al. 1990

Dermatology

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Familial multiple sclerosis: Clinical, histocompatibility, and viral serological studies

Eldridge

McFarland

Sever

et al. 1978

Annals of Neurology

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Evaluation of presumed "multiple sclerosis families" and comparison with recently reported families has led us to the following observations: (1) Seven of our original fourteen presumptive multiple sclerosis families had to be eliminated after personal clinical evaluation of family members failed to confirm the diagnosis in a second close relative. (2) No segregation of HLA type was noted between affected and unaffected individuals in our seven bona fide multiple sclerosis families, and no consistent segregation was noted in the twenty-eight families reported elsewhere. This supports other genetic evidence that there is not a single, major gene mapping in the HLA complex which predisposes to multiple sclerosis. (3) The DW2 antigen was increased in frequency among affected members of our families, and the A3 B7 haplotype was more frequent among affected members of other families reported. But unaffected members also tended to have an increased frequency of these same antigens. (4) No relationship was noted between HLA type and antimeasles antibody titer within our families.

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Transient Loss of Hla B27

Kahan

Georgiadis

1978

The Lancet

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Loss of Hla Antigens Associated With Hormonal State

Cited by 5 publications

References 0 publications

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Erythema multiforme Associated with Autoreactivity to 17α-Hydroxyprogesterone

Familial multiple sclerosis: Clinical, histocompatibility, and viral serological studies

Transient Loss of Hla B27

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