Loss of IL-7R and IL-15R Expression Is Associated with Disappearance of Memory T Cells in Respiratory Tract following Influenza Infection

Shen, Ching-Hung; Ge, Qing; Talay, Oezcan; Eisen, Herman N.; Garcı́a-Sastre, Adolfo; Chen, Jianzhu

doi:10.4049/jimmunol.180.1.171

Cited by 38 publications

(43 citation statements)

References 34 publications

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“…tail injection of 10,000 CFUs of wild-type LM 10403S into B6 mice will yield millions of CFUs in both the spleen and liver 3 d postinfection, whereas the bacterial load following the same dose of rLM-SIY will border the limit of detection (data not shown). Notably, a recent study has demonstrated that 2C T cells can differentiate into longlived memory T cells, persisting at least 225 d postinfection, using a recombinant influenza virus expressing the SIY peptide, named WSN-SIY (48). By contrast to rLM-SIY infection, Ag is detectable for at least 8 d postinfection after WSN-SIY infection (J. Chen, personal communication).…”

Section: Discussionmentioning

confidence: 99%

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells

Priatel

Chen

Huang

et al. 2009

The Journal of Immunology

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Ag encounter by naive CD8 T cells initiates a developmental program consisting of cellular proliferation, changes in gene expression, and the formation of effector and memory T cells. The strength and duration of TCR signaling are known to be important parameters regulating the differentiation of naive CD8 T cells, although the molecular signals arbitrating these processes remain poorly defined. The Ras-guanyl nucleotide exchange factor RasGRP1 has been shown to transduce TCR-mediated signals critically required for the maturation of developing thymocytes. To elucidate the role of RasGRP1 in CD8 T cell differentiation, in vitro and in vivo experiments were performed with 2C TCR transgenic CD8 T cells lacking RasGRP1. In this study, we report that RasGRP1 regulates the threshold of T cell activation and Ag-induced expansion, at least in part, through the regulation of IL-2 production. Moreover, RasGRP1−/− 2C CD8 T cells exhibit an anergic phenotype in response to cognate Ag stimulation that is partially reversible upon the addition of exogenous IL-2. By contrast, the capacity of IL-2/IL-2R interactions to mediate Ras activation and CD8 T cell expansion and differentiation appears to be largely RasGRP1-independent. Collectively, our results demonstrate that RasGRP1 plays a selective role in T cell signaling, controlling the initiation and duration of CD8 T cell immune responses.

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Section: Discussionmentioning

confidence: 99%

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells

Priatel

Chen

Huang

et al. 2009

The Journal of Immunology

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“…Indeed, IL-7 participates in T-cell responses to antigenic stimulation. [35][36][37] Moreover, most of the molecules that were induced after IL-7 treatment were described as participating in T-cell homing into these organs during inflammatory reactions. [38][39][40][41][42] The expression patterns of chemokines/chemokine receptors suggest that naive and memory CD4 ϩ T cells are directed to the gut through CCR6/CCL20 and/or CCR9/CCL25 expression, whereas all T-cell subsets (but the TEM CD8 ϩ , which barely express CCR7) might migrate into the skin and the lungs where CCR7-ligands (CCL19, CCL21) expression is increased.…”

Section: Discussionmentioning

confidence: 99%

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

Beq

Rozlan

Gautier

et al. 2009

Blood

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Interleukin-7 (IL-7), the principal cytokine implicated in thymopoiesis and peripheral T-cell homeostasis, is presently under evaluation in human diseases characterized by persistent lymphopenia. Unexpectedly, before the eventual IL-7-driven T-cell expansion, all treated patients showed a profound T-cell depletion 24 hours after injection. The current study uses the rhesus macaque model to investigate the mechanisms involved in this IL-7-induced T-cell depletion. We identify a new critical function of IL-7 that induces massive and rapid T-cell migration from the blood into various organs, including lymph nodes, parts of the intestine, and the skin. This homing process was initiated after the induction of chemokine receptor expression by circulating T cells and the production of corresponding chemokines in target organs. Finally, we demonstrate that the IL-7-induced cell cycling is initiated within these organs before T cells migrate back into the bloodstream, indicating that T-cell homing is required for in vivo IL-7 function. (Blood. 2009;114:816-825)

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“…Recombinant WSN-SIY virus encoding the SIY epitope in the neuroaminidase stalk was described previously (29). Mice were anesthetized with 2,2,2-tribromoethanol (Avertin) and infected either i.n.…”

Section: Methodsmentioning

confidence: 99%

B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation

Talay

Shen

Chen

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Studies have shown that T-cell-dendritic cell (DC) interaction is required for efficient DC maturation. However, the identities of the molecules that mediate the interaction in vivo are largely unknown. Here, we show that maturation of DCs as well as CD8 T-cell responses were impaired in B7-H1-deficient (B7-H1 ؊/؊ ) mice to influenza virus infection. Both defects were restored by transferring B7-H1-expressing naïve T cells into B7-H1 ؊/؊ mice. Similarly, transferring DCs from wild-type mice or from RAG1 ؊/؊ mice that had been injected with B7-H1-expressing naïve T cells also restored CD8 T-cell responses in B7-H1 ؊/؊ mice. These results demonstrate that B7-H1 on naïve T cells is required to condition immature DCs to undergo efficient maturation when they encounter microbial infection. In return, the mature DCs stimulate a robust T-cell reponse against the infecting pathogen.DC conditioning ͉ DC matuation ͉ T cell activation

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Loss of IL-7R and IL-15R Expression Is Associated with Disappearance of Memory T Cells in Respiratory Tract following Influenza Infection

Cited by 38 publications

References 34 publications

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation

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