2017
DOI: 10.1371/journal.pone.0184441
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Loss of long-term non-progressor and HIV controller status over time in the French Hospital Database on HIV - ANRS CO4

Abstract: ObjectivesWe studied the frequency and risk factors for loss of long-term non-progressor (LTNP) and HIV controller (HIC) status among patients identified as such in 2005 in the French Hospital Database on HIV (FHDH-ANRS CO4).MethodsWe selected patients who were treatment-naïve and asymptomatic in 2005 (baseline). Those with ≥8 years of known HIV infection and a CD4 cell nadir ≥500/mm3 were classified as LTNP and those with ≥10 years of known HIV infection and 90% of plasma viral load (VL) values ≤500 copies/ml… Show more

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Cited by 13 publications
(12 citation statements)
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“…In one multinational observational study of individuals followed from seroconversion (CASCADE), virus control (<500 copies RNA/mL) occurred in a small minority (1.4%) but once achieved was maintained in most (the probability of maintaining control over 20 years was 0.74) [ 11 ]. In a multicenter study of controllers (Collaboration of Observational HIV Epidemiological Research Europe [COHERE]), progression was rare and was predicted by a low CD4/CD8 ratio and intermittent viremia [ 67 ]; similar findings were noted in a French study [ 68 ]. In smaller pathogenesis-oriented studies, heightened inflammation and T-cell activation predated and often predicted virologic progression [ 17 , 69 , 70 ].…”
Section: Can We Learn Anything From Controllers Who Eventually Progrementioning
confidence: 77%
See 1 more Smart Citation
“…In one multinational observational study of individuals followed from seroconversion (CASCADE), virus control (<500 copies RNA/mL) occurred in a small minority (1.4%) but once achieved was maintained in most (the probability of maintaining control over 20 years was 0.74) [ 11 ]. In a multicenter study of controllers (Collaboration of Observational HIV Epidemiological Research Europe [COHERE]), progression was rare and was predicted by a low CD4/CD8 ratio and intermittent viremia [ 67 ]; similar findings were noted in a French study [ 68 ]. In smaller pathogenesis-oriented studies, heightened inflammation and T-cell activation predated and often predicted virologic progression [ 17 , 69 , 70 ].…”
Section: Can We Learn Anything From Controllers Who Eventually Progrementioning
confidence: 77%
“…Virologic rebound or progression among elite controllers is uncommon [ 11 , 65 68 ] and poorly understood. In one multinational observational study of individuals followed from seroconversion (CASCADE), virus control (<500 copies RNA/mL) occurred in a small minority (1.4%) but once achieved was maintained in most (the probability of maintaining control over 20 years was 0.74) [ 11 ].…”
Section: Can We Learn Anything From Controllers Who Eventually Progrementioning
confidence: 99%
“…However, viral control differs among LTNPs and the reason for this difference is currently unknown. LTNPs maintaining high viral loads are prone to long-term disease progression, with reduced life expectancy compared to HIV negative individuals (14, 15). Analysis of the underlying reason for the differing levels of viral control in LTNPs may facilitate an understanding of HIV pathogenesis and may provide for new approaches to immune intervention.…”
Section: Introductionmentioning
confidence: 99%
“…Individuals who spontaneously control HIV have smaller latent reservoirs and display functionally superior CD8+ T cell responses, providing a model for functional cure (37, 38). However, loss of controller/non-progressor status is frequent, possibly due to ongoing viral replication in tissue sites that are inaccessible to cytolytic T cells (3941).…”
Section: How Can Immune Retargeting Therapies Overcome the Failure Ofmentioning
confidence: 99%