Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function

Huls, Gerwin; Es, Josien van; Haan, de Gerald; Os, van Ronald

doi:10.1038/leu.2012.354

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…56 TCF7, which is a downstream target of Wnt signaling, regulates self-renewal of HSPCs. 57 We found that CCND1, CCND3, AXIN2, and TCF7 were all up-regulated in ANGPTL7-treated HSPCs. Translocation of β-CATENIN into nucleus in HSPCs following ANGPTL7 stimulation further validated that Wnt signaling was activated by ANGPTL7 treatment.…”

Section: Discussionmentioning

confidence: 71%

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells

Xiao

Jiang

et al. 2015

Haematologica

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Section: Discussionmentioning

confidence: 71%

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells

Xiao

Jiang

et al. 2015

Haematologica

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“…Here, we show that the exogenous stimulation of Wnt signaling maintained growth of CTB-ORGs, coinciding with the expression of LGR5, nuclear β-catenin, and TCF-1. The latter, expressed in a subset of vCTBs, was shown to control self-renewal of different stem cells types ( Huls et al., 2013 , Yi et al., 2011 ). Since TCF-3 and -4 proteins were undetectable in proliferative CTBs of tissues and organoids, we speculate that TSC proliferation could be mainly triggered by nuclear β-catenin-TCF-1 complexes.…”

Section: Discussionmentioning

confidence: 99%

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

et al. 2018

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SummaryDefective placentation is the underlying cause of various pregnancy complications, such as severe intrauterine growth restriction and preeclampsia. However, studies on human placental development are hampered by the lack of a self-renewing in vitro model that would recapitulate formation of trophoblast progenitors and differentiated subtypes, syncytiotrophoblast (STB) and invasive extravillous trophoblast (EVT), in a 3D orientation. Hence, we established long-term expanding organoid cultures from purified first-trimester cytotrophoblasts (CTBs). Molecular analyses revealed that the CTB organoid cultures (CTB-ORGs) express markers of trophoblast stemness and proliferation and are highly similar to primary CTBs at the level of global gene expression. Whereas CTB-ORGs spontaneously generated STBs, withdrawal of factors for self-renewal induced trophoblast outgrowth, expressing the EVT progenitor marker NOTCH1, and provoked formation of adjacent, distally located HLA-G+ EVTs. In summary, we established human CTB-ORGs that grow and differentiate under defined culture conditions, allowing future human placental disease modeling.

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“…Cox analysis was used to determine whether GE-based risk score provides additional prognostic information compared to previously-identified gene expression-based prognostic markers such as ADAM29 (a disintegrin and metalloprotease domain 29), AKAP12 (a kinase (PRKA) anchor protein 12), DMD , LPL , NRIP1 (Nuclear receptor-interacting protein 1), SET10 (Septin 10), SPG20 (Spastic paraplegia 20), TCF7 , TCL1A , TPM1 (Tropomyosin 1), ZAP70 gene expression, the Herold's GEP-based prognostic score (PS8), and Del17p ( Table 2 ) [ 22 – 27 ]. None of these genes were included in the current 20 prognostic genes.…”

Section: Resultsmentioning

confidence: 99%

“…Mice deficient in the TCF7 gene develop intestinal and mammary adenomas, suggesting a role for TCF7 as a tumor suppressor [ 26 ]. Furthermore, TCF7 has been also reported to be expressed in hematopoietic stem cells and that its loss diminishes hematopoietic stem/progenitor cell function [ 27 ]. These data suggest that the role of Wnt in B-cell malignancies is controversial, as it may have potential oncogenic, as well as tumor suppressor functions.…”

Section: Discussionmentioning

confidence: 99%

Identification of a 20-Gene Expression-Based Risk Score as a Predictor of Clinical Outcome in Chronic Lymphocytic Leukemia Patients

Samra

Klein

Commes

et al. 2014

BioMed Research International

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Despite the improvement in treatment options, chronic lymphocytic leukemia (CLL) remains an incurable disease and patients show a heterogeneous clinical course requiring therapy for many of them. In the current work, we have built a 20-gene expression (GE)-based risk score predictive for patients overall survival and improving risk classification using microarray gene expression data. GE-based risk score allowed identifying a high-risk group associated with a significant shorter overall survival (OS) and time to treatment (TTT) (P ≤ .01), comprising 19.6% and 13.6% of the patients in two independent cohorts. GE-based risk score, and NRIP1 and TCF7 gene expression remained independent prognostic factors using multivariate Cox analyses and combination of GE-based risk score together with NRIP1 and TCF7 gene expression enabled the identification of three clinically distinct groups of CLL patients. Therefore, this GE-based risk score represents a powerful tool for risk stratification and outcome prediction of CLL patients and could thus be used to guide clinical and therapeutic decisions prospectively.

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Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function

Cited by 9 publications

References 14 publications

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

Identification of a 20-Gene Expression-Based Risk Score as a Predictor of Clinical Outcome in Chronic Lymphocytic Leukemia Patients

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