2024
DOI: 10.1073/pnas.2418096121
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Loss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer

Ikrame Naciri,
Minzhi Liang,
Ying Yang
et al.

Abstract: Plasticity, a key hallmark of cancer, enables cells to transition into different states, driving tumor heterogeneity. This cellular plasticity is associated with cancer progression, treatment resistance, and relapse. Cancer stem cells (CSCs) play a central role in this process, yet the molecular factors underlying cancer cell stemness remain poorly understood. In this study, we explored the role of XIST (X-inactive specific transcript) long noncoding RNA in ovarian cancer stemness and plasticity through in sil… Show more

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