Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals (Diabetes Metab J 2021;45:27-42)

Jin, Heung Yong; Moon, Seong Su; Calcutt, Nigel A.

doi:10.4093/dmj.2021.0034

Cited by 1 publication

(5 citation statements)

References 9 publications

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“…Most of the combined in vivo and post-mortem assessments here reported have not yet been described in detail in a prospective, parallel study in aged, diabetic rats, and comparison with the available literature data is therefore difficult [1,8,10,24]. However, partial results obtained in different studies on somatic function are consistent with our data and marked differences have been evidenced between the two models when the autonomic nervous system was investigated [31].…”

Section: Discussionsupporting

confidence: 86%

“…The diabetic condition was evaluated by measurement of non-fasting tail vein blood glucose level using an Accu-Check Aviva blood glucose meter (Roche Diagnostic S.p.A., Mannheim, Germany). The ZDF group reached the target for being considered diabetic at the age of 8 weeks, as expected [1].…”

Section: Diabetes Induction and General Assessment Of Animal Conditionssupporting

confidence: 73%

“…Diabetes, one of the most frequent chronic diseases affecting nearly 500 million people worldwide [1], has entered the top 10 causes of death following a significant increase of 70% since 2000. Diabetes is also responsible for the largest rise in male deaths among the top 10, with an 80% increase since 2000 (https://www.who.int/news-room (accessed on 30 September 2022).…”

Section: Introductionmentioning

confidence: 99%

“…To date, suggested treatments from preclinical studies have failed to be effective in clinical trials, due to many concerns involving drug schedules, targeted mechanisms, inappropriate preclinical models, clinical study design, and disregarded risk factors [1,7].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, a great number of animal models of DPN have been developed, but none mimics all the features of human disease [8]. For instance, the late neuropathological features of human peripheral neuropathy have no counterpart in rodent animal models [1].…”

Section: Introductionmentioning

confidence: 99%

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Multimodal Comparison of Diabetic Neuropathy in Aged Streptozotocin-Treated Sprague–Dawley and Zucker Diabetic Fatty Rats

et al. 2022

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The development and progression of diabetic polyneuropathy (DPN) are due to multiple mechanisms. The creation of reliable animal models of DPN has been challenging and this issue has not yet been solved. However, despite some recognized differences from humans, most of the current knowledge on the pathogenesis of DPN relies on results achieved using rodent animal models. The simplest experimental DPN model reproduces type 1 diabetes, induced by massive chemical destruction of pancreatic beta cells with streptozotocin (STZ). Spontaneous/transgenic models of diabetes are less frequently used, mostly because they are less predictable in clinical course, more expensive, and require a variable time to achieve homogeneous metabolic conditions. Among them, Zucker diabetic fatty (ZDF) rats represent a typical type 2 diabetes model. Both STZ-induced and ZDF rats have been extensively used, but only very few studies have compared the long-term similarities and differences existing between these two models. Moreover, inconsistencies have been reported regarding several aspects of short-term in vivo studies using these models. In this study, we compared the long-term course of DPN in STZ-treated Sprague–Dawley and ZDF rats with a multimodal set of readout measures.

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