Lost to follow-up and associated factors among patients with drug resistant tuberculosis in Ethiopia: A systematic review and meta-analysis

Andargie, Assefa; Tessema, Asressie Molla; Tadese, Fentaw; Zewdie, Segenet

doi:10.1371/journal.pone.0248687

Cited by 14 publications

(13 citation statements)

References 25 publications

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“…Comparable results were presented by a study from Uganda which presented 8.8% lost to follow up 19 . A cohort analysis has also revealed comparable findings and presented an overall 8.66% loss to follow up with high heterogeneity in Ethiopia 20 .…”

Section: Discussionmentioning

confidence: 53%

Occupation and Treatment Outcome of Multi-drug resistant tuberculosis Patients

Munir¹,

Rehman²,

Nazir³

et al. 2021

PJMHS

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Background: Tuberculosis is a contagion from ancient times comprising around one 3rd of global population on the wedge of infection with Mycobacterium tuberculosis complex where under developed and developing countries is coping with high burden of the disease. Aim: To observe the most prevalent occupation and treatment outcome in both Genders of MDR TB patients. Methodology: Health Research Institute-National Institute of Health TB Research Centre in collaboration with Department of Pulmonology, King Edward Medical University/Mayo Hospital Lahore from january 2014 to December 2020. A pre-designed questionnaire was used to collect data from MDR Tb patients after verbal informed consent. Patients were followed to see the final outcome on completion of anti-tubercle treatment. Data was entered and analyzed by using SPSS. Results: Out of total 450 MDR TB patients analyzed in this study a higher proportion of 54.9% were males and 45.1% were females with an overall mean age of patients as 39.64±17.52 years. Most of 159(35.4%) patients had no skills and were labors whereas most of 145 (28.2%) females were house wives. Almost 71% of the patients successfully completed the treatment including 45% cured on the basis of availability of final smear and culture reports.. Conclusion: A high mortality rate of MDR TB patients was observed while most of the TB patients in this study belong to labor class while most of the women were housewives. Keywords: Tuberculosis, MDR TB, Occupation, Treatment outcome, loss to follow up.

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Section: Discussionmentioning

confidence: 53%

Occupation and Treatment Outcome of Multi-drug resistant tuberculosis Patients

Munir¹,

Rehman²,

Nazir³

et al. 2021

PJMHS

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“…Any discrepancy was resolved by consensus. The studies which obtained more than 60% as per the reviewer’s judgment were included in the analysis 7 ( Supplemental Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Systematic review and meta-analysis of comorbidities and associated risk factors in Indian patients of community-acquired pneumonia

Ghia

Rambhad

2022

SAGE Open Medicine

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Objective: Comorbidities and risk factors have a major implication on incidence, complications, mortality, and management of community-acquired pneumonia complications and treatment outcomes. This study attempts to identify the same in the Indian population through a systematic review and meta-analysis. Methods: We screened observational studies (between January 1990 and February 2021) that reported potential comorbidities and other factors associated with increased risk of community-acquired pneumonia in the Indian population (⩾12 years) using PubMed, Google Scholar, and manual search. The risk of bias was identified using the Joanna Briggs Institute checklist for prevalence studies. Meta-analysis was conducted by using the random intercept logistic regression model. Results: Twenty-three studies were included in this analysis. The most prevalent comorbidities were chronic obstructive pulmonary disease (24.2%; 95% confidence interval: 16.4%–34.2%), hypertension (23.7%; 95% confidence interval: 13.6%–38.1%), and diabetes mellitus (16%; 95% confidence interval: 9.9%–24.7%). The prevalence of community-acquired pneumonia was high in patients with a current or previous history of smoking (51.4%; 95% confidence interval: 42.3%–61%) and advanced age ⩾50 years: (55.8%; 95% confidence interval: 48.4%–62%). Conclusions: Comorbid conditions like chronic obstructive pulmonary disease, hypertension, and diabetes mellitus and factors like advanced age and smoking history were common risk factors for community-acquired pneumonia in the Indian population.

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“…A study in Namibia reported that male gender, age group 15–24 years, treatment service providers, TB intensive phase patients, and living in border/transit areas were factors for LTFU in TB patients ( 17 ). A meta-analysis study reported that the high prevalence of LTFU in TB patients due to multidrug resistance, and the anatomic location of tuberculosis were significant factors ( 18 ). The significance of risk factors of LTFU (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Patients who are readmitted after LTFU are more likely to redevelop infectious active TB and are at higher risk of developing further drug resistant strains of tuberculosis ( 19 , 20 ). According to reports on the economic challenges of TB drug non-adherence, an estimated 52 MDR-TB patients lost to follow-up resulted in 5 patients developing XDR-TB, 3 newly infected MDR-TB and a new XDR-TB, and 3 deaths ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

“…LTFU can increase the risk of clinical deterioration, treatment failure, and further complications in tuberculosis patients. Patients who discontinue treatment too early are one of the leading causes of treatment failure ( 18 ). The dropout rate is critical because low LTFU as a result of improved TB management will reduce re-treatment case by 10–20% in the coming years ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Lost to Follow-Up among Tuberculosis Patients during the Public-Private Mix Era in Rural Area of Indonesia

Rahayu

Susilastuti²,

Saefurrohim

et al. 2023

Ethiop J Health Sci

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BACKGROUND: Indonesia’s national Tuberculosis (TB) strategy is public-private mix (PPM). The PPM aims to treat patients who have lost sight during TB treatment as these patients are TB carriers and at risk of transmitting TB. The purpose of this study was to identify predictive factors for loss to follow-up (LFTU) among TB patients receiving treatment when the PPM was at place in Indonesia. METHODS: The design of this study was a retrospective cohort study. The data used in this study was sourced from the Tuberculosis Information System (SITB) of Semarang which was recorded routinely during 2020-2021. Univariate analysis, crosstabulation, and logistic regression were performed on 3434 TB patients meeting the minimum variables. RESULTS: The participation of health facilities in reporting TB during the PPM era in Semarang reached 97.6% consisting of 37 primary healthcare center (100%), 8 public hospitals (100%), 19 private hospitals (90.5%), and a community-based pulmonary health center (100%). The regression analysis reveal that the predictive factors of LTFU-TB during the PPM are the year of diagnosis (AOR=1.541; p-value=<0.001; 95% CI=1.228-1.934), referral status (AOR=1.562, p-value=0.007; 95% CI=1.130-2160), healthcare and social security insurance ownership (AOR=1.638; p-value=<0.001; 95% CI=1.263-2.124), drugs source (AOR=4.667; p-value=0.035; 95% CI=1.117-19.489). CONCLUSIONS: The PPM strategy in dealing with LTFU patients should focus on TB patients without Healthcare and Social Security Insurance and who receive TB treatment rather than program drugs.

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Lost to follow-up and associated factors among patients with drug resistant tuberculosis in Ethiopia: A systematic review and meta-analysis

Cited by 14 publications

References 25 publications

Occupation and Treatment Outcome of Multi-drug resistant tuberculosis Patients

Occupation and Treatment Outcome of Multi-drug resistant tuberculosis Patients

Systematic review and meta-analysis of comorbidities and associated risk factors in Indian patients of community-acquired pneumonia

Lost to Follow-Up among Tuberculosis Patients during the Public-Private Mix Era in Rural Area of Indonesia

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