Lotus leaf alleviates hyperglycemia and dyslipidemia in animal model of diabetes mellitus

Abstract

The purpose of this study was to investigate the effects of lotus leaf on hyperglycemia and dyslipidemia in animal model of diabetes. Inhibitory activity of ethanol extract of lotus leaf against yeast α-glucosidase was measured in vitro. The effect of lotus leaf on the postprandial increase in blood glucose levels was assessed in streptozotocin-induced diabetic rats. A starch solution (1 g/kg) with and without lotus leaf extract (500 mg/kg) was administered to the rats after an overnight fast, and postprandial plasma glucose levels were monitored. Four-week-old db/db mice were fed a basal diet or a diet containing 1% lotus leaf extract for 7 weeks after 1 week of acclimation to study the chronic effect of lotus leaf. After sacrifice, plasma glucose, insulin, triglycerides (TG), total cholesterol (CHOL), high-density lipoprotein (HDL)-CHOL, and blood glycated hemoglobin levels were measured. Lotus leaf extract inhibited α-glucosidase activity by 37.9%, which was 1.3 times stronger than inhibition by acarbose at a concentration of 0.5 mg/mL in vitro. Oral administration of lotus leaf extract significantly decreased the area under the glucose response curve by 35.1% compared with that in the control group (P < 0.01). Chronic feeding of lotus leaf extract significantly lowered plasma glucose and blood glycated hemoglobin compared with those in the control group. Lotus leaf extract significantly reduced plasma TG and total CHOL and elevated HDL-CHOL levels compared with those in the control group. Therefore, we conclude that lotus leaf is effective for controlling hyperglycemia and dyslipidemia in an animal model of diabetes mellitus.

Effects of potato and lotus leaf extract intake on body composition and blood lipid concentration

“…Lotus extract has been reported to have an effect of reducing fasting blood glucose, total cholesterol, and triglyceride in diabetic animals, thus showing anti-diabetic and antilipid effects [ 15 ]. In addition, it has been reported that lotus extract has an effect of improving obesity and hyperlipidemia [ 16 ], reducing blood glucose [ 17 ], anti-oxidation, and protecting neurons [ 18 ] in animals with high fat diet-induced obesity. Also, it has been known that long-term use of lotus leaves might exert a suppressive effect on adipose tissue differentiation at the cellular level [ 19 ].…”

Effect of Ultra-fine Traditional Chinese Medicine Compounds on Regulation of Lipid Metabolism and Reduction in Egg Cholesterol of Laying Hens

“…The earlier studies showed that the serum lipid level decreased significantly in high-fat rabbit diet by providing rabbit with Crataegus pinnatifida which is rich in total flavonoids from Crataegus pinnatifida, meanwhile, it has been confirmed that Astragalus membranaceus and Codonopsis pilosula could protect the liver and the heart, which also benefits for lipid metabolism (Jiang et al, 2013;Li et al, 2012;Wu et al, 2014). Moreover, some reports showed that Lotus leaf leads to a decrease in the levels of serum lipid (Cho et al, 2007;Kim et al, 2013). Furthermore, many studies uncovered that TCM could affect total lipid metabolism by reducing serum lipid level (Guo et al, 2015;Kwon et al, 2005;Tu et al, 2003).…”

Effects of thermal processing methods and simulated digestion on the phenolic content and antioxidant activity of lotus leaves

“…, anticancer (Nakamura et al, 2013), hypolipidemic, weight loss (Wu et al, 2010), antibacterial and anti-inflammatory (Liu et al, 2013) effects and can prevent cardiovascular diseases (Subashini & Rajadurai, 2011) and diabetes (Kim et al, 2013).…”

“…It also has numerous food and medicinal applications (Huang et al, ; Lin, Kuo, Lin, & Chiang, ). Modern medical research has shown that lotus leaf possesses anti‐HIV (Yoshiki et al, ), antioxidant (Lee, Kim, & Je, ), anticancer (Nakamura et al, ), hypolipidemic, weight loss (Wu et al, ), antibacterial and anti‐inflammatory (Liu et al, ) effects and can prevent cardiovascular diseases (Subashini & Rajadurai, ) and diabetes (Kim et al, ).…”