Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

Fu, Xin; Fan, Shaoguang; Li, Shuliang; Chen, Yisheng; Wu, Haoming; Guo, Yan-Long

doi:10.1186/s12967-015-0756-x

Cited by 7 publications

(10 citation statements)

References 46 publications

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“…Many people fail to meet the recommended daily intake of calcium (800–1000 mg per day) due to inadequate diet, impaired absorption, or food intolerances [ 57 , 58 ]. Vitamin D 3 , whose active form 1,25(OH) 2 D 3 is a cofactor required for calcium absorption in the gastrointestinal tract, is also strongly correlated with bone density [ 59 ]. Vitamin D insufficiency (25(OH)D 3 serum levels <50 nmol/L) is also not uncommon due to diet, lack of sun exposure, or genetic mutations [ 60 ], and many studies have shown that the majority of postmenopausal women in areas around the world have insufficient vitamin D levels [ 61 , 62 , 63 ].…”

Section: Reviewmentioning

confidence: 99%

Osteoporosis: Modern Paradigms for Last Century’s Bones

Kruger¹,

Wolber²

2016

Nutrients

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The skeleton is a metabolically active organ undergoing continuously remodelling. With ageing and menopause the balance shifts to increased resorption, leading to a reduction in bone mineral density and disruption of bone microarchitecture. Bone mass accretion and bone metabolism are influenced by systemic hormones as well as genetic and lifestyle factors. The classic paradigm has described osteoporosis as being a “brittle bone” disease that occurs in post-menopausal, thin, Caucasian women with low calcium intakes and/or vitamin D insufficiency. However, a study of black women in Africa demonstrated that higher proportions of body fat did not protect bone health. Isoflavone interventions in Asian postmenopausal women have produced inconsistent bone health benefits, due in part to population heterogeneity in enteric bacterial metabolism of daidzein. A comparison of women and men in several Asian countries identified significant differences between countries in the rate of bone health decline, and a high incidence rate of osteoporosis in both sexes. These studies have revealed significant differences in genetic phenotypes, debunking long-held beliefs and leading to new paradigms in study design. Current studies are now being specifically designed to assess genotype differences between Caucasian, Asian, African, and other phenotypes, and exploring alternative methodology to measure bone architecture.

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Section: Reviewmentioning

confidence: 99%

Osteoporosis: Modern Paradigms for Last Century’s Bones

Kruger¹,

Wolber²

2016

Nutrients

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“…The incidences of osteoporosis and fractures is rising rapidly due to the aging society in China [1]. Age is an independent risk factor for fracture and global aging brings urgency to fracture prevention [2]. Abnormal gut microbiota can affect the health of the elderly [3].…”

Section: Introductionmentioning

confidence: 99%

“…We suspected that serum levels of TAMO were associated with osteoporosis. Furthermore, osteoporosis is the main cause of hip fractures [2]. Therefore, the study evaluates the serum levels of Trimethylamine N-Oxide (TMAO), a gut microbial metabolite, in 286 postmenopausal women with hip fracture.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

Liu

Guo

Meng

et al. 2020

Aging

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The study evaluates the serum levels of Trimethylamine N-Oxide (TMAO), a gut microbial metabolite, in 286 postmenopausal women with hip fracture. From January 1, 2018 to December 31, 2018, eligible patients were included. Same women without fracture mated age were enrolled. TMAO serum levels were tested by ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The serum levels of TMAO were significantly higher in patients with hip fracture than in those controls (P<0.001). The serum levels of TMAO were also higher in patients with hip fracture only than in those who also had upper limb fracture (P=0.001). High level of TMAO was proved a predictor of both hip fracture and had upper limb fracture combined hip fracture, after the adjustment of other existing risk factors [e.g., for each 1 uM increase of TMAO, odd ratio 1.16 (95% CI, 1.07-1.25), P < 0.001; and 1.12 (95% CI, 1.03-1.26), P=0.008, respectively]. In summary, increased TMAO serum levels associated with high risk of hip fracture, suggesting that increase TMAO may contribute to osteoporosis and fracture in postmenopausal women.

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“…15 Among the included patients, we identified the subgroup who sustained a concomitant fracture of the upper limb. 16 In this subgroup, a single fall resulted in both a hip and an upper limb fracture. In addition, total hip BMD of the proximal femur was measured using dual x-ray absorptiometry (Hologic QDR2000/QDR4500; Hologic, Inc. Bedford MA, USA) in all the participants.…”

Section: Clinical Informationmentioning

confidence: 89%

“…Cognitive impairment was assessed with the Mini‐Mental State Examination (MMSE), and a score < 24 indicates the presence of a cognitive impairment . Among the included patients, we identified the subgroup who sustained a concomitant fracture of the upper limb . In this subgroup, a single fall resulted in both a hip and an upper limb fracture.…”

Section: Methodsmentioning

confidence: 99%

Circulating serum level of retinoic acid and hip fractures among postmenopausal women

Liu

Fan

et al. 2018

J American Geriatrics Society

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PURPOSE The aim of this study was to evaluate the serum levels of retinoic acid (RA), an active form of vitamin A, in postmenopausal women with hip fractures from Zhengzhou, China. METHODS This was a case‐control study from the Affiliated Hospital of Zhengzhou University. Serum samples were drawn from 375 postmenopausal women who were diagnosed as having hip fracture and 750 matched controls without fracture. Serum RA levels were evaluated as both a continuous variable and a categorical variable in quintiles. RESULTS The results showed that the serum levels of RA were significantly (P = .039) higher in patients with hip fracture compared with controls. In univariate and multivariate logistic regression analysis, for each 1 ng/mL increase of serum level of RA, the unadjusted and adjusted risk of hip fracture would be increased by 5% (odds ratio [OR] = 1.05; 95% confidence interval [CI] = 1.00‐1.10; P = .035) and 2% (OR = 1.02; 95% CI = 0.95‐1.11; P = .096), respectively. In multivariate models comparing the fifth with the third quintiles of RA, the RA was associated with hip fracture, and adjusted risk of hip fracture would be increased by 52% (OR = 1.52; 95% CI = 1.13‐1.42; P = .011). CONCLUSIONS The results of our study suggest that subclinical higher levels of RA may increase the risk of hip fracture in postmenopausal women, particularly among the top quintile of serum RA. J Am Geriatr Soc 67:336–341, 2019.

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Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

Cited by 7 publications

References 46 publications

Osteoporosis: Modern Paradigms for Last Century’s Bones

Osteoporosis: Modern Paradigms for Last Century’s Bones

Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

Circulating serum level of retinoic acid and hip fractures among postmenopausal women

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