Low Alpha‐tocopherol Levels in Livers of Weaner Sheep With Nutritional Myopathy

Steele, P.; Peet, R. L.; Skirrow, S. Z.; Hopkinson, W.I.; Masters, H. G.

doi:10.1111/j.1751-0813.1980.tb02580.x

Cited by 23 publications

(10 citation statements)

References 13 publications

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“…It was concluded that during vitamin E depletion in sheep a-tocopherol concentration in plasma was a good index of vitamin E status under the experimental conditions employed. a-Tocopherol : Vitamin E : Nutritional myopathy : Sheep Vitamin E deficiency can be an important factor in the development of nutritional myopathy in ruminants (Steele et al 1980;. Measurements of atocopherol in plasma are used as an index of vitamin E status in ruminants which assumes that there is a direct relationship between the plasma and the tissue concentrations of atocopherol (McMurray et al 1983).…”

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confidence: 99%

Plasma and tissue concentrations of α-tocopherol during vitamin E depletion in sheep

et al. 1993

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To determine the relationship between plasma and tissue a-tocopherol concentrations during vitamin E depletion, weaned lambs were placed on a vitamin E-deficient diet for 0, 1, 2, 4, 8 and 12 weeks. aTocopherol was measured in plasma, erythrocytes, liver, adrenal, adipose tissue, three different skeletal muscles and heart muscle. The a-tocopherol concentration in plasma fell at the same rate as the atocopherol concentration in skeletal muscles, heart muscle, adrenal and adipose tissue. The a-tocopherol concentration in liver and erythrocytes fell at a faster rate than that of plasma and all muscle tissues. There were significant correlations between a-tocopherol concentration in plasma and a-tocopherol concentrations in all the tissues measured. Different skeletal muscles had significantly different concentrations of a-tocopherol which may relate to their differing susceptibility to nutritional myopathy. The increase in malondialdehyde in oxidatively-stressed muscle tissue and the correlation with atocopherol concentration in most muscle tissues indicated that the muscles had reduced antioxidant capacity in vitro as a result of vitamin E depletion. It was concluded that during vitamin E depletion in sheep a-tocopherol concentration in plasma was a good index of vitamin E status under the experimental conditions employed. a-Tocopherol : Vitamin E : Nutritional myopathy : Sheep

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confidence: 99%

Plasma and tissue concentrations of α-tocopherol during vitamin E depletion in sheep

et al. 1993

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“…As no clinical or histological symptoms of white muscle disease were found (e.g., via heart histology), the concentrations of VitE in serum were in the normal range, and the animals were younger than most described in literature, it still cannot be concluded that the lambs and kids were actually deficient in VitE. Additionally, Steele et al. (1980) defined that only VitE concentrations of less than 1 μ g/g liver of weaner sheep is said to be deficient.…”

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confidence: 97%

Effect of vitamin E supplementation of sheep and goats fed diets supplemented with polyunsaturated fatty acids and low in Se

Liesegang

Staub

Wichert

et al. 2008

Animal Physiology Nutrition

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Effect of vitamin E supplementation of sheep and goats fed diets supplemented with polyunsaturated fatty acids and low in Se There are situations of low supply of both micronutrients. As VitE is involved in ruminal biohydrogenation of polyunsaturated fatty acids (PUFA) and their protection against oxidation in metabolism, diets supplemented with PUFA may challenge VitE to an extent making recommended supplies insufficient. Twelve goats and sheep each were fed a diet supplemented with PUFA and characterised by low Se and limited VitE contents during the last 2 months of gestation and the first 2 months of lactation. The basal diet consisted of hay and concentrate. Six goats and sheep received extra VitE, while the control groups received no extra VitE. Blood and milk samples were taken. In addition, liver, heart muscle and spleen samples were obtained from the offspring after slaughtering at an age of 8 weeks. No significant changes were observed in serum Se and VitE. A significant increase in serum VitE concentrations between 2 and 4 weeks postpartum (pp) was evident in the supplemented kids. In 4, 6 and 8 weeks pp, the serum concentrations of VitE in the supplemented kids were significantly higher compared to the unsupplemented group. In the kids, VitE was higher in liver of the supplemented groups. There were no significant differences in response to extra VitE between sheep and goat. The kids responded to serum VitE different from that of lambs, as a significant difference was observed between supplemented and unsupplemented animals in the goat kids, but not the lambs. In conclusion, goats and sheep have to be viewed differently and may not be considered alike relating to VitE/Se metabolism and requirements, especially in young animals. received no extra VitE. Blood and milk samples were taken. In addition, liver, heart muscle and spleen samples were obtained from the offspring after slaughtering at an age of eight weeks. No significant changes were observed in serum Se and VitE. A significant increase in serum VitE concentrations between two and four weeks pp was evident in the supplemented kids. Four, six and eight weeks pp, the serum concentrations of VitE in the supplemented kids were significantly higher compared to the unsupplemented group. In the kids, VitE was higher in livers of the supplemented groups. There were no significant differences in the response to extra VitE between sheep and goat. The kids responded in serum VitE different from the lambs, since a significant difference was observed in between supplemented and unsupplemented animals in the goat kids, but not the lambs. In conclusion, goats and sheep have to be looked at differently and may not be considered alike relating to VitE/Selen metabolism and requirements, especially in young animals. Effect of vitamin E supplementation2

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“…To a large extent, therefore, the ruminant now requires tocopherol only to overcome the toxic effects of excess PUFA in the diet, or to prevent lipid peroxidationand membrane damage in the absence of the far more efficient glutathione peroxidase. The only report of nutritional myopathy in ruminants with seemingly adequate selenium levels (and not obviously receiving excess PUFA) is that described in Western Australia (43) where weaner sheep grazed cereal stubble and were given cereal grain supplements. Low tocopherol levels (0.6-0.9 mg/kg) were found in the livers of these sheep.…”

Section: Ruminant's Tocopherol Requirementsmentioning

confidence: 96%

“…(27) Levels as low as 0.7 mg/kg have been reported for dry summer feed grazed by sheep in some areas of Western Australia. (43) After harvesting and during storage, the tocopherol content of pasture and other crops may fall further. sometimes to zero.…”

Section: Tocopherol Intakementioning

confidence: 99%