Low Ambient Temperature Lowers Cholecystokinin and Leptin Plasma Concentrations in Adult Men

Pizon, Monika; Tomasik, Przemysław; Sztefko, Krystyna; Szafran, Z

doi:10.2174/1874288200903010005

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Lastly, serum leptin levels were greatly decreased in mice housed at 22°C. Cold exposure of 30 min at 4°C already reduced plasma leptin levels in humans (Pizon et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality

et al. 2017

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Housing of laboratory mice at room temperature (22°C) might be considered a constant cold stress, which induces a thermogenic program in brown adipose tissue (BAT). However, the early adaptive response of white adipose tissue (WAT), the fat storage organ of the body, to a change from thermoneutrality to room temperature is not known. This was investigated here for various WAT depots, focusing on epididymal WAT (eWAT), widely used as reference depot. Male adult diet-induced obese (DIO) C57BL/6JOlaHsd mice housed at thermoneutrality (29°C), were for 5 days either switched to room temperature (22°C) or remained at thermoneutrality. Energy metabolism was continuously measured using indirect calorimetry. At the end of the study, serum metabolomics and WAT transcriptomics were performed. We confirmed activation of the thermogenic program in 22°C housed mice. Body weight and total fat mass were reduced. Whole body energy expenditure (EE) was increased, with a higher fatty acid to carbohydrate oxidation ratio and increased serum acylcarnitine levels, while energy intake was not significantly different between the two groups. Transcriptome analysis of eWAT identified tissue remodeling and inflammation as the most affected processes. Expression of pro-inflammatory M1 macrophage-related genes, and M1 over M2 macrophage ratio were decreased, which might be linked to an increased insulin sensitivity. Markers of thermogenesis were not altered in eWAT. Decreased expression of tryptophan hydroxylase 2 (Tph2) and cholecystokinin (Cck) might represent altered neuroendocrine signaling. eWAT itself does not show increased fatty acid oxidation. The three measured WATs, epididymal, mesenteric, and retroperitoneal, showed mainly similar responses; reduced inflammation (s100a8), decreased carbohydrate oxidation, and no or small differences in fatty acid oxidation. However, Ucp1 was only expressed and increased in rWAT in 22°C housed mice. Cck expression was decreased in the three WATs, significantly in eWAT and rWAT, in contrast to Tph2, which was decreased in eWAT while not expressed in mWAT and rWAT. Our data show that tissue remodeling, inflammation and neuroendocrine signaling are early responses in WAT to a moderate decrease in environmental temperature.

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“…Lastly, serum leptin levels were greatly decreased in mice housed at 22°C. Cold exposure of 30 min at 4°C already reduced plasma leptin levels in humans (Pizon et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality

et al. 2017

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“…Few studies have examined the effect of ambient temperature without exercise on appetite-regulating hormones. Acute (30–100 min) cold (2–6 °C) exposure has previously been reported to decrease plasma leptin [54, 56], and increase plasma ghrelin levels [62]. Whereas acute (30-100 min) heat (30–31 °C) exposure has been reported to decrease plasma ghrelin levels [28, 62].…”

Section: Introductionmentioning

confidence: 99%

The effects of exercise and ambient temperature on dietary intake, appetite sensation, and appetite regulating hormone concentrations

et al. 2019

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Background It is not clear whether the frequently reported phenomenon of exercise-induced anorexia is exacerbated or blunted in warm or cold environments. Therefore, this study investigated the effects of exercise in three different environmental temperatures vs. rest, on perceptions of appetite, appetite regulating hormones, and food intake. Methods In a randomized repeated-measures design, 18 Canadian Armed Forces members (14 male, 4 female) completed four 8-h trials in a thermally-controlled chamber: one 8-h resting trial at 21 °C (Sedentary); and three trials where participants completed two 2-h circuits of standardized military tasks interspersed with two 2-h rest periods, once at 30 °C (Hot), once at 21 °C (Temperate), and once at − 10 °C (Cold). Participants consumed military field rations ad libitum and had their appetite assessed with visual analogue scales. Plasma concentrations of GLP-1, PYY, acylated ghrelin, and leptin were also determined. Results Appetite was perceived as being suppressed in the heat compared to the cold ( p < 0.05). While neither exercise nor environmental temperature altered circulating GLP-1 levels, exercise in all environments increased blood concentrations of PYY ( p < 0.05). Leptin concentrations were elevated in the heat and diminished in the cold (p < 0.05), and acylated ghrelin concentrations were affected by both exercise and ambient temperature resulting in Sedentary = Cold>Temperate = Hot ( p < 0.05). Contrary to the changes in appetite perceptions and hormonal concentrations, dietary intake was not different between conditions ( p > 0.05). Relative energy intake (total 24 h energy intake minus 24 h energy expenditure) on the other hand, was significantly higher during the Sedentary condition than it was during any of the active conditions (p < 0.05). Most (83%) of the participants were in a positive energy balance during the Sedentary condition, whereas during most (80%) of the active conditions (Hot, Temperate, Cold) participants were in a negative energy balance. Conclusions In this study where food was freely available, variations in ambient temperature, exercise vs. rest, appetite-regulating hormone concentrations, and subjective appetite sensation were not associated with any changes in dietary intake within 24-h of acute, prolonged exercise.

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Variations in leptin and insulin levels within one swimming season in non-obese female cold water swimmers

Gibas-Dorna

Checińska

Korek

et al. 2016

Scandinavian Journal of Clinical and Laboratory Investigation

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Low Ambient Temperature Lowers Cholecystokinin and Leptin Plasma Concentrations in Adult Men

Cited by 4 publications

References 16 publications

Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality

Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality

The effects of exercise and ambient temperature on dietary intake, appetite sensation, and appetite regulating hormone concentrations

Variations in leptin and insulin levels within one swimming season in non-obese female cold water swimmers

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