Low anterior resection syndrome (LARS) in ovarian cancer patients - A multi-centre comparative cohort study

Harpain, Felix; Kranawetter, M; Zott, Tobias; Lazaridis, Ioannis; Guenin, Marc-Olivier; Ninković, M.; Kronberger, Irmgard; Tapiolas, Ingrid; Espín‐Basany, Eloy; Dauser, Bernhard; Herbst, F.; Koh, Cherry; Stift, Anton; Teleky, B.; Reinthaller, Alexander; Grimm, Christoph; Riss, Stefan

doi:10.1016/j.ijsu.2020.04.019

Cited by 10 publications

(20 citation statements)

References 29 publications

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Section: Discussionmentioning

confidence: 59%

“…Among baseline characteristics, the mean age of patients in this study was 10 years younger than those included in the study conducted by Kranawetter et al [ 19 ] and 15 years younger than a comparative study conducted by Harpain et al [ 18 ]. Mean BMI was 27 kg/m 2 in comparison to 24 kg/m 2 found in a multicenter comparative study [ 18 ] and by Kranawetter et al [ 19 ]. Charlson Comorbidity Index (CCI) was higher than the rest of the two studies, that is, 7 versus 2 [ 18 ] and 4 [ 19 ], while ASA class distribution was similar, that is, ASA class 2 noted in 86% versus 75% [ 18 ] and 78% [ 19 ].…”

Section: Discussionmentioning

confidence: 59%

“…Mean BMI was 27 kg/m 2 in comparison to 24 kg/m 2 found in a multicenter comparative study [ 18 ] and by Kranawetter et al [ 19 ]. Charlson Comorbidity Index (CCI) was higher than the rest of the two studies, that is, 7 versus 2 [ 18 ] and 4 [ 19 ], while ASA class distribution was similar, that is, ASA class 2 noted in 86% versus 75% [ 18 ] and 78% [ 19 ]. All patients in this study had ECOG zero status in comparison to 95% in the study by Kranawetter et al [ 19 ].…”

Section: Discussionmentioning

confidence: 66%

“…This is the first study to assess LARS in an EOC eastern population (especially the subcontinental region of Asia) undergoing debulking surgery with low anterior resection. To date, only two studies conducted among the western population have been published on this topic [ 18 , 19 ]. A total of 21 patients were included in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, no data on LARS in EOC are available except for recently published two European studies [ 18 , 19 ]. Thus, this study aims to determine the prevalence and identify risk factors for LARS in EOC patients undergoing upfront or interval debulking surgery, including large bowel resection with low anterior resection.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Risk Factors of Low Anterior Resection Syndrome in Epithelial Ovarian Cancer Surgery

Yasin¹,

Usmani²,

Mohsin³

et al. 2022

Cureus

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence and Risk Factors of Low Anterior Resection Syndrome in Epithelial Ovarian Cancer Surgery

Yasin¹,

Usmani²,

Mohsin³

et al. 2022

Cureus

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Side‐to‐end reanastomosis after low‐anterior resection (STELAR): Outcomes, feasibility, and description of procedure performed by a gynecologic oncology service

Khetan

Muderspach

Miller

et al. 2022

Journal of Surgical Oncology

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Background and Objectives: Low anterior rectosigmoid resection for a gynecologic disease is usually performed in concert with other procedures and can result in significant morbidity should anastomotic complication occur. This study examined surgical outcomes of side-to-end reanastomosis after low anterior resection (STELAR) performed by gynecologic oncology service. Methods: This is a case series examining consecutive patients who underwent STELAR for gynecologic indications by a single gynecologic oncology group from 2009 to 2018. Prospectively collected institutional surgical database was searched for STELAR, and standard descriptive statistics were used to describe intraoperative and postoperative complications specific to reanastomosis.Results: A total of 69 women underwent STELAR, with median age and body mass index of 54 years and 24 kg/m 2 , respectively. 63.8% of patients had ovarian cancer and 84.4% had stage III-IV disease. The median estimated blood loss was 875 ml. Four (5.8%) women underwent protective loop colostomy at the time of STELAR.Postoperatively, there was 1 (1.4%) case of abscess formation within 30 days and 1(1.4%) case of anastomotic leak 5 weeks after STELAR that required reoperation and diversion. No cases of fistula were clinically identified. Conclusion:Side-to-end reanastomosis may be a safe and feasible procedure to accomplish low rectosigmoid anastomosis in women with gynecologic disease.

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Baseline characteristics and recruitment for SWOG S1820: altering intake, managing bowel symptoms in survivors of rectal cancer (AIMS-RC)

Sun,

Thomson,

Crane

et al. 2024

Support Care Cancer

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Purpose Many survivors of rectal cancer experience persistent bowel dysfunction. There are few evidence-based symptom management interventions to improve bowel control. The purpose of this study is to describe recruitment and pre-randomization baseline sociodemographic, health status, and clinical characteristics for SWOG S1820, a trial of the Altering Intake, Managing Symptoms in Rectal Cancer (AIMS-RC) intervention. Methods SWOG S1820 aimed to determine the preliminary efficacy, feasibility, and acceptability of AIMS-RC, a symptom management intervention for bowel health, comparing intervention to attention control. Survivors with a history of cancers of the rectosigmoid colon or rectum, within 6–24 months of primary treatment completion, with a post-surgical permanent ostomy or anastomosis, and over 18 years of age were enrolled. Outcomes included total bowel function, low anterior resection syndrome, quality of life, motivation for managing bowel health, self-efficacy for managing symptoms, positive and negative affect, and study feasibility and acceptability. Results The trial completed accrual over a 29-month period and enrolled 117 participants from 34 institutions across 17 states and one US Pacific territory. At baseline, most enrolled participants reported self-imposed diet adjustments after surgery, persistent dietary intolerances, and bowel discomfort post-treatment, with high levels of constipation and diarrhea (grades 1–4). Conclusions SWOG S1820 was able to recruit, in a timely manner, a study cohort that is demographically representative of US survivors of rectal cancer. Baseline characteristics illustrate the connection between diet/eating and bowel symptoms post-treatment, with many participants reporting diet adjustments and persistent inability to be comfortable with dietary intake. ClinicalTrials.gov registration date 12/19/2019. ClinicalTrials.gov Identifier NCT#04205955.

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Low anterior resection syndrome (LARS) in ovarian cancer patients - A multi-centre comparative cohort study

Cited by 10 publications

References 29 publications

Prevalence and Risk Factors of Low Anterior Resection Syndrome in Epithelial Ovarian Cancer Surgery

Prevalence and Risk Factors of Low Anterior Resection Syndrome in Epithelial Ovarian Cancer Surgery

Side‐to‐end reanastomosis after low‐anterior resection (STELAR): Outcomes, feasibility, and description of procedure performed by a gynecologic oncology service

Baseline characteristics and recruitment for SWOG S1820: altering intake, managing bowel symptoms in survivors of rectal cancer (AIMS-RC)

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