Low back pain (LBP) is one of the most frequent occupational health problems and accounts for a large number of losses in working days and disability for workers in modern industrialized countries. The aim of this paper was to investigate the prevalence of lower back problem and to associate risk factors among high school teachers. A cross-sectional study was conducted among high school teachers using self-administered questionnaires, which were distributed to randomly selected school teachers of 7 boys' and 10 girls' high schools across the city of Kerman and collected between October and November 2010. A total of 296 teachers returned completed questionnaires, yielding a response rate of 78.9%. The 12-month prevalence of LBP was 68.8%, which reporting with moderate disability. The results of multiple logistic regression analysis revealed that females [odds ratio (OR): 1.85, 95% confidence interval (CI): 1.51-2.00] were positively correlated to LBP. Awkward arm posture (OR: 1.81, 95% CI: 1.24-2.62) and awkward body posture (OR: 1.23, 95% CI: 0.87-1.49) were significantly associated with LBP. Psychosocial job demands and job dissatisfaction were also significantly associated with LBP. Smoking cigarette was three times more likely to develop lower back pain when compared with non-smokers. The prevalence of LBP was high among high school teachers. A wide variety of LBP risk factors were identified in the current study.