Low blood neutrophil concentrations among extremely low birth weight neonates: data from a multihospital health-care system

Expected ranges for blood neutrophil concentrations of neonates: the Manroe and Mouzinho charts revisited

“…3 For this study, we used their 1979 1 and 1994 2 publications as templates, applying a modern blood cell analyzer and very large sample sizes to reexamine the range of neutrophil counts of neonates. We made two additional modifications in approach; first, we did not include values from patients with certain diagnoses known to have a large proportion of either abnormally high neutrophil counts (Down syndrome, 11 trisomy 18, 13, 12 early-onset bacterial sepsis 13 ) or abnormally low neutrophil counts (pregnancy-induced hypertension, 5,6 early-onset bacterial sepsis 7,8 or congenital neutropenia 9,10 ). Second, rather Neutrophil counts of neonates N Schmutz et al than display the range of values as was done in the previous reports, 1,2 we displayed the 5th percentile value, the mean value and the 95th percentile value.…”

“…The values were included in the analysis only if the CBC was obtained within the first 10 days (240 h) after delivery. Results were excluded from patients with the following diagnoses: high proportion of abnormally low neutrophil concentrations; maternal pregnancy-induced hypertension; 5,6 early-onset bacterial sepsis 7,8 or a discharge diagnosis of congenital neutropenia; 9,10 or abnormally high neutrophil concentrations; Down syndrome; 11 trisomy 13 12 or trisomy; 18, 12 or early-onset bacterial sepsis. 13 The gestational ages used in this study were those assigned by obstetrical dates, unless this was changed by the neonatal examination.…”

Hematologic effects of placental pathology on very low birthweight infants born to mothers with preeclampsia

“…2 Consistent with our findings, neutropenia severity has been correlated with the severity of growth restriction and prematurity. 4 Kinetic investigations have suggested that neutropenia in infants born to mothers with preeclampsia is secondary to decreased production of WBCs as evidenced by decreased circulating, marginated, storage, progenitor and proliferative neutrophils. 2 Our data suggest that the decreased production of WBCs is not associated with histologic changes in the placenta including placental infarction or vasculopathy.…”

“…It has previously been postulated that both neonatal neutropenia and thrombocytopenia result from decreased production of WBCs and platelets (Plt) from placental insufficiency. [2][3][4][5][6][7][8][9] Preeclampsia is also known to have associated placental pathology. 10 Different placental histopathologies are associated with specific clinical features of preterm preeclampsia.…”

Association of BPD and IVH with early neutrophil and white counts in VLBW neonates with gestational age <32 weeks

“…Asterisks in Tables 1 and 2 indicate the significance of these comparisons. For comparison with other studies 15 the percentage with low neutrophil count is separately tabulated by white count quartiles for infants born at extremely low birth weight (<1000 g). Neutrophil count in the lowest quartile (<1000 per ml) was considered 'low'.…”