Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients with radiotherapy

Saito, Nobue; Imai, Yutaka; Muto, Takashi; Sairenchi, Toshimi

doi:10.1007/s00520-012-1620-7

Cited by 35 publications

(20 citation statements)

References 14 publications

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“…Previous studies have suggested hemoglobin levels and body mass index are correlated with the severity of radiotherapy induced OM severity. [ 17 , 33 ] In contrast, this current study did not detect association of these factors with oral mucosal reaction. These results may be due to the fact that most study subjects had relatively normal hemoglobins and BMIs.…”

Section: Discussioncontrasting

confidence: 97%

“…Currently many factors have been associated with OM. The most commonly recognized risk factors for OM include poor oral hygiene and periodontal disease, [ 14 ] chronic alcohol consumption, cigarette smoking, [ 15 ] hyposalivation, [ 16 ] low body mass index (BMI < 18.5), [ 17 ] as well as concurrent diseases such as diabetes mellitus. In addition, age, sex and therapeutic regimen have been suggested as risk factors.…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma

Tao

Gao²,

Liu³

et al. 2017

Medicine

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To investigate risk factors for acute oral mucosal reaction during head and neck squamous cell carcinoma radiotherapy.A retrospective study of patients with head and neck squamous cell carcinoma who underwent radiotherapy from November 2013 to May 2016 in Anhui Provincial Cancer Hospital was conducted. Data on the occurrence and severity of acute oral mucositis were extracted from clinical records. Based on the Radiation Therapy Oncology Group (RTOG) grading of acute radiation mucosal injury, the patients were assigned into acute reaction (grades 2–4) and minimum reaction (grades 0–1) groups. Preradiotherapy characteristics and treatment factors were compared between the 2 groups. Multivariate logistic regression analysis was used to detect the independent factors associated with acute oral mucosal reactions.Eighty patients completed radiotherapy during the study period. Oral mucosal reactions were recorded as 25, 31, and 24 cases of grades 1, 2, and 3 injuries, respectively. Significant differences between acute reaction and minimum reaction groups were detected in cancer lymph node (N) staging, smoking and diabetes history, pretreatment platelet count and T-Helper/T-Suppressor lymphocyte (Th/Ts) ratio, concurrent chemotherapy, and total and single irradiation doses.Multivariate analysis showed that N stage, smoking history, single dose parapharyngeal irradiation, and pretreatment platelet count were independent risk factors for acute radiation induced oral mucosal reaction. Smoking history, higher grading of N stage, higher single dose irradiation, and lower preirradiation platelet count may increase the risk and severity of acute radiation oral mucosal reaction in radiotherapy of head and neck cancer patients.

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Section: Discussioncontrasting

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma

Tao

Gao²,

Liu³

et al. 2017

Medicine

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“…Our previous study also found that body weight loss ≥ 5% was a related risk factor to severe ROM ( 19 ). Two other studies conducted in oral cavity cancer patients found that lower BMI was significantly related with severe ROM ( 49 , 50 ). The underlying mechanism might be that malnutrition could interfere with mucosal regeneration due to decreased cellular migration and renewal resulting from poor nutrition status ( 51 ).…”

Section: Discussionmentioning

confidence: 88%

Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study

Shu

Zeng

et al. 2020

Front. Oncol.

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Background and Aims Malnutrition is a concern in patients with nasopharyngeal carcinoma (NPC) during chemoradiotherapy (CRT)/radiotherapy (RT), which is considered to be related with radiation–induced oral mucositis (ROM). The study aimed to evaluate the nutritional status of NPC patients during RT and investigate its association with ROM. Methods A prospective study was conducted in NPC patients. Patients were divided into three subgroups (mild, moderate, and severe groups) based on the duration of severe ROM (≥ grade 3). Body weight, body mass index (BMI), albumin, prealbumin, NRS2002, and ROM grade were assessed on a weekly basis before and during CRT/RT. The statistical analysis was performed in the overall group and between three subgroups. Results A total of 176 patients were included. In the overall group, body weight and BMI kept decreasing since week 1 of RT, and NRS2002 score and ROM grade increased (p < 0.001). NRS2002 score and prealbumin levels were significantly different between each subgroup (p ≤ 0.046). Significant differences were observed in the proportion of patients receiving enteral nutrition, duration of parenteral nutrition, and total calories provided by nutritional support among three subgroups (p = 0.045–0.001). Conclusions Malnutrition occurred early in NPC patients and worsened continuously during RT. ROM was strongly associated with nutritional status. Nutritional support should be provided at the start of RT, especially in patients at high-risk of severe ROM.

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“…Some studies have reported an association between poor nutrition and development of mucositis [35][36][37]. The potential mechanism of the association between BMI and oral mucositis is uncertain [38]. Oral mucositis is one of the most serious problems connected to head and neck cancer radiotherapy [39,40], and severe cases may require feeding tube placement.…”

Section: Discussionmentioning

confidence: 99%

“…After this time period, oral mucositis did not differ significantly between the groups. Saito et al [38] examined whether low BMI could be a risk factor for oral mucositis. In their study, 33 patients with oral cancer received radiotherapy and they found that low BMI (< 22) may be a risk factor of moderate to severe oral mucositis.…”

Section: Discussionmentioning

confidence: 99%

Differences in quality of life in obese and normal weight head and neck cancer patients undergoing radiation therapy

Egestad

Nieder

2014

Support Care Cancer

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Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients with radiotherapy

Abstract: Low BMI may be a risk factor of moderate to severe oral mucositis.

Cited by 35 publications

References 14 publications

Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma

Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma

Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study

Differences in quality of life in obese and normal weight head and neck cancer patients undergoing radiation therapy

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