Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma

Tao, Zhenchao; Gao, Jin; Liu, Qian; Huang, Yifan; Zhou, Yan; Yang, Liping; He, Jian; Yang, Jianqi; Wang, Ru; Zhang, Yangyang

doi:10.1097/md.0000000000008446

Cited by 39 publications

(24 citation statements)

References 35 publications

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“…Patients with higher N staging were administered with a larger radiation field and more dosage, and therefore were more likely to develop G2 or worse radiation mucositis. This has previously been reported [6,21] . One of the limitations of present study was that the sample size is small, partially due to that the incidence of hypopharyngeal cancer was low.…”

Section: Discussionsupporting

confidence: 66%

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Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Wang¹,

Lu²,

Huang³

et al. 2020

Preprint

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Background This present retrospective single center study was intended to investigate the factors associated with acute radiation oral mucositis or dermatitis during hypopharyngeal carcinoma radiotherapy.Methods From May 2012 to December 2018, previously untreated 93 patients with hypopharyngeal squamous cell carcinoma received radiotherapy in Affiliated Cancer Hospital of Zhengzhou University were enrolled. Radiation Therapy Oncology Group (RTOG) scoring criteria were used for assessing the severity of toxicities. Patients are therefore classified into “mild reaction group” (G0~G1) and “acute reaction group” (G2~G4). Single variate was applied to screen out factors with significant difference between mild and acute reaction groups, multivariate analysis was used to detect independent risk factors from those related. A total of 16 medical and laboratory indexes were included to examine, i.e., gender, age, smoking history, primary site, history of hypotension and diabetes, treatment modalities, dose, T (tumor) staging, N (reginal lymph node) staging, as well as hemoglobin value (1 week before radiotherapy). Relevant data used for the study were collected from clinical records.Results Total of 93 subjects completed radiotherapy. Acute mucositis occurred in 75 patients, and 27 cases developed acute radiation dermatitis. Smoking history, post-operative radiotherapy, concurrent chemotherapy, T staging, N staging, total dose (Gy) for GTV, single fraction dose (Gy) for GTV, and hemoglobin value (1 week before radiotherapy) showed significant differences between G0~G1 and G2~G4 groups of oral mucosa reaction; significant differences between mild and acute dermatitis reaction groups were found in diabetes history, hemoglobin value, age, total dose (Gy). Multivariate analysis showed that higher hemoglobin value ( OR = 1.120, P = 0.031), smoking history ( OR = 0.070, P = 0.031) were independent risk factor of acute OM; significant relationships for acute skin reaction were found with hemoglobin value ( OR = 1.059, P = 0.034) and older age ( OR = 1.068, P = 0.036).Conclusion Multivariate analysis showed higher hemoglobin value and smoking history to be the most relevant factors independently predicting grades 2 or higher OM; higher hemoglobin value and older age were found to be significantly associated with acute skin reaction.

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Section: Discussionsupporting

confidence: 66%

“…RTOG standard for acute radiation mucositis and dermatitis were used for grading [6,7] (Table 1); G0…”

Section: Radiation Reaction and Criteriamentioning

confidence: 99%

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Wang¹,

Lu²,

Huang³

et al. 2020

Preprint

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“…Grade 3: Conﬂuent ﬁbrinous mucositis/may include severe pain requiring narcotic. Grade 4: Ulcer, hemorrhage, or necrosis 10. Patients with OM of Grade 1 (asymptomatic) (CTCAE) and/or Grade 0 (RTOG criteria) were defined as a 0 group.…”

Section: Methodsmentioning

confidence: 99%

<p>Prevention effect of low-temperature atomization inhalation for radiation induced oral mucositis in patients with head and neck cancer undergoing radiotherapy</p>

Bai¹,

Chen²,

Ma³

et al. 2019

CMAR

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Purpose: To investigate the prevention effect of low-temperature atomization inhalation for radiation induced oral mucositis (OM) in patients with head and neck cancer (HNC) undergoing radiotherapy. Patients and methods: A total of 68 patients with HNC (including nasopharyngeal cancer) undergoing radiotherapy were divided into an intervention group (33 cases) and a control group (35 cases). During radiotherapy, the intervention group received low-temperature (between 4°C and 8°C) atomization inhalation; while the control group received normal temperature (between 18°C and 24°C) atomization inhalation. Atomization inhalation was performed twice a day, 20 minutes per time, using distilled water. The incidence and severity of OM was evaluated every week during radiotherapy. The comparation was made between the two groups. Results: The two groups were comparable among age, sex, Eastern Cooperative Oncology group (ECOG) score, body mass index (BMI) before radiotherapy, BMI loss during radiotherapy, original tumor site, pathological type, TNM stage, and mean oral cavity irradiated dose. There was a significant difference in the incidence of OM between the two groups ( P <0.05). There were fewer patients with severe OM in the intervention group compared to the control group ( P <0.05). The onset time of OM in the intervention group was delayed by about 4 days compared to that in the control group ( P <0.05). Low-temperature atomization inhalation helped to avoid radiotherapy interruption in the intervention group. No patient in the intervention group suffered any adverse reaction for low-temperature atomization inhalation treatment. Conclusions: Low-temperature atomization inhalation can reduce the incidence and severity of OM, and slow down the progression process of it. It can be used as a new prevention method during radiotherapy, and should be promoted in clinical practice.

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“…Tao dkk. 8 menggunakan desain studi kohort retrospektif, melakukan analisis univariat dan multivariat. Kedua analisis tersebut mendapatkan hasil yang signifikan (nilai p = 0,024 dan 0,028).…”

Section: Tabel 1 Hasil Pencar Ian Dar I Pubmed Dan Ebscohostunclassified

Hubungan antara Perilaku Merokok dengan Kejadian Mukositis Berat pada Pasien Keganasan Kepala dan Leher yang Menjalani Radioterapi

Pulungan

Hariyanto

Nugroho

et al. 2018

Radioter Onkol Indones

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Tujuan: Mukositis akibat radiasi adalah reaksi yang paling mengganggu yang terjadi ketika pasien kanker kepala leher menjalani radiasi. Telah diketahui bahwa merokok dapat mengganggu aktivitas sitotoksik Natural Killer cells dengan meningkatkan produksi sitokin pro-inflamasi dan proliferasi sel T terhadap mitogen. Kasus berbasis bukti ini mengevaluasi dampak riwayat merokok sebelumnya terhadap kejadian mukositis pada pasien kanker kepala leher yang menjalani pengobatan radiasi.Metode: Pencarian bukti-bukti dari literatur dilakukan di PubMed dan EBSCOhost. Seluruh penelitian yang memenuhi kriteria inklusi dan eksklusi dinilai aspek validitas, kepentingan dan aplikabilitasnya dengan menggunakan kuesioner penilaian kritis dari Oxford Center of Evidence-Based MedicineHasil: Dari 104 penelitian yang sudah ditemukan, 6 penelitian dipilih untuk ditelaah lebih lanjut. Hanya terdapat satu studi, Tao dkk., yang menunjukkan hubungan yang signifikan antara riwayat merokok dan reaksi mukosa oral akibat radiasi meskipun dengan Interval Kepercayaan yang rendah (1.258-58.23). Lima penelitian lainnya gagal menunjukkan hubungan yang signifikan.Kesimpulan: Tidak ada penelitian yang menunjukkan dampak riwayat merokok sebelumnya dengan kejadian mukositis pada pasien kanker kepala leher yang menjalani radiasi. Namun, lima dari enam penelitian menunjukkan insiden mukositis yang lebih tinggi pada kelompok pasien yang memiliki riwayat merokok sebelumnya.

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Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma

Cited by 39 publications

References 35 publications

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

<p>Prevention effect of low-temperature atomization inhalation for radiation induced oral mucositis in patients with head and neck cancer undergoing radiotherapy</p>

Hubungan antara Perilaku Merokok dengan Kejadian Mukositis Berat pada Pasien Keganasan Kepala dan Leher yang Menjalani Radioterapi

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