Low bone density and low serum levels of soluble RANK ligand are associated with severe arterial calcification in patients with Takayasu arteritis

Bezerra, Mailze Campos; Calomeni, G. D.; Caparbo, Valéria F.; Gebrim, Eloísa Maria Mello Santiago; Rocha, Manoel de Souza; Pereira, Rosa Maria Rodrigues

doi:10.1093/rheumatology/kei045

Cited by 31 publications

(26 citation statements)

References 20 publications

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“…In the present study we found significantly higher VCS in patients who had undergone cardiovascular events. These results were similar to those of Bezerra et al [11], which showed that low serum sRANKL levels were positively associated with severe arterial calcification in patients with Takayasu’s arteritis. In this study we found that cardiovascular events and mortality are significantly higher in patients with low serum sRANKL levels.…”

Section: Discussionsupporting

confidence: 92%

Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients

Wei

Wang²,

Wang³

et al. 2009

Blood Purif

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Background: Vascular calcification and cardiovascular events are common in hemodialysis patients. Receptor activator of nuclear factor-κB ligand (RANKL) plays an important role in vascular calcification and bone remodeling. This study investigates the effects of soluble RANKL (sRANKL) on cardiovascular events in hemodialysis patients. Methods: Serum sRANKL levels of 47 patients were tested by ELISA. Vascular calcification was radiographically measured and patients were followed up for 2 years. Results: After 2 years, 10 (36.6%) patients had experienced cardiovascular events. Seventy-five percent (6/9) of mortality was due to cardiovascular disease. Patients experiencing cardiovascular events showed significantly higher vascular calcification scores (VCS) (3.20 ± 2.74 vs. 1.19 ± 1.60; t = 2.999; p < 0.05). Multivariate regression analysis showed that serum sRANKL levels, vascular calcification scores and phosphorus were independent determinants of cardiovascular events. Conclusion: Serum sRANKL levels and VCS are independent risk factors, and hemodialysis patients with low serum sRANKL levels have a risk of cardiovascular events.

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Section: Discussionsupporting

confidence: 92%

Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients

Wei

Wang²,

Wang³

et al. 2009

Blood Purif

View full text Add to dashboard Cite

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“…92,93 Vascular calcification and calciphylaxis rarely are associated with malignancy. [94][95][96] " Unknown Gain Gain Chronic inflammation 30 " " " Loss Gain Interleukin 1 [31][32][33] " " " Loss Gain Tumor necrosis factor-a 34 The mechanisms for malignancy-associated hypercalcemia and metastatic calcification are variable but include: (1) tumor production of PTH or PTH-related peptide, vitamin D, or various cytokines; (2) upregulation of RANKL; (3) down-regulation of OPG; or (4) a combination of up-regulated RANKL and downregulated OPG. [97][98][99][100][101][102][103][104][105] Like other diseases that are associated with extraosseous mineral deposition, these cancers may be associated with simultaneous osseous mineral loss.…”

Section: Malignancy Hypercalcemia and Extraosseous Mineralizationmentioning

confidence: 99%

Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B

Weenig

2008

Journal of the American Academy of Dermatology

168

175

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“…Ramsey-Goldman and Manzi (18) reported an association between osteoporosis and cardiovascular disease in patients with a diagnosis of systemic lupus erythematosus. Bezerra et al (19), studying 30 premenopausal women with Takayasu arteritis, demonstrated an association between low-bone mineral density values and the severity of arterial calcification, a finding that contributed to the idea of an association between bone metabolism and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 96%

Bone metabolism and vascular calcification

Danilevicius

Lopes

Pereira

2007

Braz J Med Biol Res

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Osteoporosis and atherosclerosis are chronic degenerative diseases which have been considered to be independent and whose common characteristic is increasing incidence with age. At present, growing evidence indicates the existence of a correlation between cardiovascular disease and osteoporosis, irrespective of age. The morbidity and mortality of osteoporosis is mainly related to the occurrence of fractures. Atherosclerosis shows a high rate of morbidity and especially mortality because of its clinical repercussions such as angina pectoris, acute myocardial infarction, stroke, and peripheral vascular insufficiency. Atherosclerotic disease is characterized by the accumulation of lipid material in the arterial wall resulting from autoimmune and inflammatory mechanisms. More than 90% of these fatty plaques undergo calcification. The correlation between osteoporosis and atherosclerosis is being established by studies of the underlying physiopathological mechanisms, which seem to coincide in many biochemical pathways, and of the risk factors for vascular disease, which have also been associated with a higher incidence of low-bone mineral density. In addition, there is evidence indicating an action of antiresorptive drugs on the reduction of cardiovascular risks and the effect of statins, antihypertensives and insulin on bone mass increase. The mechanism of arterial calcification resembles the process of osteogenesis, involving various cells, proteins and cytokines that lead to tissue mineralization. The authors review the factors responsible for atherosclerotic disease that correlate with low-bone mineral density.

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Low bone density and low serum levels of soluble RANK ligand are associated with severe arterial calcification in patients with Takayasu arteritis

Abstract: Severe arterial calcification in TA is associated with low values of BMD and sRANKL, reinforcing the possible link between bone and vascular disease.

Cited by 31 publications

References 20 publications

Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients

Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients

Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B

Bone metabolism and vascular calcification

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