Low Bone Density and Renal Dysfunction Following Environmental Cadmium Exposure in China

Nordberg, Gunnar F.; Jin, Taiyi; Bernard, Alfred; Fierens, Sébastien; Buchet, J. P.; Ye, Tingting; Kong, Qinghu; Wang, Hong-Fu

doi:10.1579/0044-7447-31.6.478

Cited by 166 publications

(53 citation statements)

References 10 publications

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“…However, there were fewer older participants in this study probably due to the low life expectancy of Torres Strait Islander people. High cadmium levels and acute health effects were observed in highly contaminated areas of Japan (2.87 mg/g creatinine) (Honda et al, 2003) and China (2.4-14.5 mg/g creatinine) (Nordberg et al, 2002). This study provides the first data on urinary cadmium levels among Indigenous residents of the Torres Strait, where levels of cadmium in the offal of some important traditional seafood are well above maximum permitted concentrations in commercially sold foods in Australia.…”

Section: Discussionmentioning

confidence: 77%

Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods

Haswell‐Elkins

Imray

Satarug³

et al. 2006

J Expo Sci Environ Epidemiol

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This study explored urinary cadmium levels among Torres Strait Islanders in response to concerns about potential health impact of high levels of cadmium in some traditional seafood (dugong and turtle liver and kidney). Cadmium levels were measured by inductively coupled mass spectrometry in de-identified urine samples collected during general screening programs in 1996 in two communities with varying dugong and turtle catch statistics. Statistical analysis was performed to identify links between cadmium levels and demographic and background health information. Geometric mean cadmium level among the sample group was 0.83 mg/g creatinine with 12% containing over 2 mg/g creatinine. Cadmium level was most strongly associated with age (46% of variation), followed by sex (females 4males, 7%) and current smoking status (smokers 4non-smokers, 4.7%). Adjusting model conditions suggested further positive associations between cadmium level and diabetes (p ¼ 0.05) and residence in the predicted higher exposure community (p ¼ 0.07). Positive correlations between cadmium and body fat in bivariate analysis were eliminated by control for age and sex. This study found only suggestive differences in cadmium levels between two communities with predicted variation in exposure from traditional foods. However, the data indicate that factors linked with higher cadmium accumulation overlap with those of renal disease risk (i.e. older, females, smokers, diabetes) and suggest that levels may be sufficient to contribute to renal pathology. More direct assessment of exposure and health risks of cadmium to Torres Strait Islanders is needed given the disproportionate level of diet-related disease and the cultural importance of dugong and turtle. This study highlights the need to consider social and cultural variation in exposure and to define ''safe'' cadmium levels during diabetes given its rising global prevalence.

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Section: Discussionmentioning

confidence: 77%

Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods

Haswell‐Elkins

Imray

Satarug³

et al. 2006

J Expo Sci Environ Epidemiol

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“…Toxic factors identified up to now include arsenic, cadmium and nephrotoxic agrochemicals (WHO, 2011). In some areas in China and Thailand, production of highly Cd polluted rice and renal dysfunctions among populations were reported (Nordberg et al, 1997;Jin et al, 2002;Honda et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of cadmium on growth parameters and plant accumulation in different rice (Oryza sativa L.) varieties in Sri Lanka

Herath¹,

Bandara

Weerasinghe³

et al. 2015

Trop. Agric. Res.

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“…The mean concentrations of cadmium in marks BW1, BW2, BW3, BW4, BW5, BW6, BW7 and BW8 are 1.33±0. 17 …”

Section: Resultsmentioning

confidence: 99%

“…Cadmium's biological half-life in bone and kidney is 38 and 10 years, respectively (16). Chronic exposure to cadmium causes kidney failure and itai-itai disease (osteoporosis and severe pain) (17,18). The standard limit of WHO and EPA for Cd in bottled drinking water is 3 and 5 µg/lrespectively (19,20).…”

Section: Introductionmentioning

confidence: 99%

The Non-carcinogenic Risk of Cadmium in Bottled Water in Different Age Groups Humans: Bandar Abbas City, Iran

Fakhri¹,

Jafarzadeh²,

Moradi³

et al. 2015

Mater Sociomed

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Introduction: The presence of heavy metals such as cadmium in drinking water resources can be dangerous for human because of toxicity and biological accumulation. The consumption of water which contains Cd in high concentration can lead to Bone and Kidney diseases. Material and Methods: In this present study, the researcher collected 432 samples of bottled water in the popular marks in summer and winter from the surface of Bandar Abbas. The cadmium concentration was measured by atomic absorption Spectrophotometer in model DR2800 through the Dithizone method. CDI, R and HQ which are caused by Cd for adult men, women and children, have been calculated and evaluated through the equations of EPA and WHO. Results: Mean of 1.73±0.19 µg/l (M±SE) is lower than the standard of WHO and EPA. However, 33.2% of all the samples have concentrations more than the standard limit of WHO, and the concentrations of 22.4% of the samples are more than EPA's standard. The CDI for different age groups is as following manner; Children>adult women>adult men. The CDI in children is more than twice as much as in the CDI for adult men and women. The mean of HQ order for different age groups is children>adult men>adult women. Since HQ of adult men (34E-5), adult women (31E-5) and children (84E-5), is lower than 1. Conclusion: It can be said that the population of Bandar Abbas is in a safe area regarding the HQ of the bottled water's cadmium.

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Low Bone Density and Renal Dysfunction Following Environmental Cadmium Exposure in China

Cited by 166 publications

References 10 publications

Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods

Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods

Effect of cadmium on growth parameters and plant accumulation in different rice (Oryza sativa L.) varieties in Sri Lanka

The Non-carcinogenic Risk of Cadmium in Bottled Water in Different Age Groups Humans: Bandar Abbas City, Iran

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