Low bone mineral density and high bone turnover in patients with non-Hodgkin's lymphoma (NHL) who receive frontline therapy: Results of a multicenter prospective study

Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients

“…Our results are, to some extent, in agreement with other studies on osteoporosis and fractures in patients with hematologic malignancies and specifically lymphoma (132)(133)(134)179). Most of the studies published on osteoporosis or fractures in lymphoma patients hitherto have been small.…”

“…It is unclear why the risk increase for lymphoma patients was more pronounced in women than in men in our study. Another small prospective study in a cohort in 61 patients with newly diagnosed NHL, reported high bone turnover (increase in bone resorption-and bone formation markers) and reduction of BMD foremost in men and patients over 55 years (134). Thus, other studies have reported increased risk in both men and women as well as in older patients.…”

“…It is not clear whether it is the lymphoma in itself, the treatment, or other factors that affect the risk for fractures. Patients with NHL have been shown to have lower BMD and higher bone turnover markers after treatment compared with before treatment (134). Further attempts have been made to identify if it is the therapy or the lymphoma disease in itself that affects osteoporosis or fracture.…”

Low Bone Mineral Density and High Bone Turnover in Patients With Non-Hodgkin's Lymphoma (NHL) Who Receive Frontline Therapy: Results of a Multicenter Prospective Study

“…Chemotherapy‐induced bone loss is a well‐established treatment complication in all patients with malignancies and bone mineral density (BMD) reduction has been reported in adult patients with lymphoma post‐chemotherapy administration 2 . Osteopenia and osteoporosis is however a common finding also in untreated patients with Non‐Hodgkin's lymphoma (NHL) 3,4 . The long‐term sequelae associated with osteoporosis remains an important issue due to the associated mortality and morbidity.…”

“…2 Osteopenia and osteoporosis is however a common finding also in untreated patients with Non-Hodgkin's lymphoma (NHL). 3,4 The long-term sequelae associated with osteoporosis remains an important issue due to the associated mortality and morbidity. Very few studies have addressed the issue of bone metabolism in the setting of adult lymphoma 5 and it remains currently unclear to what extent the harmful effects on bone in these patients are the effect of the tumor itself or the treatment.…”