Low carbohydrate diet-based intervention for obstructive sleep apnea and primary hypothyroidism in an obese Japanese man

Tokuchi, Yoshio; Nakamura, Yayoi; Munekata, Yusuke; Tokuchi, Fumio

doi:10.1186/s12930-016-0029-8

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…A case‐report study in an obese Japanese man with obstructive sleep apnea revealed that weight was improved as well as lipid and glucose levels through following an LCD program. The authors have suggested that LCD helps to improve the management of patients with obstructive sleep apnea . LCD can improve endothelial function and inflammatory status, which is an important mechanism to manage mental health and cardiovascular diseases …”

Section: Discussionmentioning

confidence: 99%

Association between a low‐carbohydrate diet and sleep status, depression, anxiety, and stress score

et al. 2020

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BACKGROUND Dietary intakes, especially carbohydrates, play an important role in blood glucose control in patients with diabetes. It is suggested that carbohydrate amounts may be effective in diabetes complications. This study aimed to reveal the association of low‐carbohydrate diet (LCD) and sleep and mental status among patients with diabetes. METHODS This cross‐sectional study was conducted among 265 women with type 2 diabetes. Anthropometric measures, as well as biochemical tests, were recorded. Dietary intakes were recorded using a validated food‐frequency‐questionnaire to calculate LCD score. To assess mental disorders and sleep quality, the Depression, Anxiety and Stress Scale and the Pittsburgh Sleep Quality Index were used respectively. RESULTS Patients in the highest LCD quartile were the ones with the lowest carbohydrate consumption. There was no significant association between cardiovascular risk factors and LCD score even after controlling confounder variables (P > 0.05). Subjects in the highest quartile of LCD score compared with those within the lowest quartile had a 69% lower risk of poor sleep after adjusting confounders. The odds of depressive symptoms were negatively related to the highest quartile of LCD score in the crude model and even after full‐adjusted model (odds ratio: 0.42; 95% confidence interval: 0.17–1.01). Participants in the highest quartile of LCD score compared with those in the lowest quartile had a 73% lower risk of anxiety. CONCLUSION It seems that patients who consumed lower carbohydrate have better sleep status and are less involved with mental disorders. However, regarding the nature of the present study, well‐designed cohort studies are suggested to be conducted in the future. © 2020 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 99%

Association between a low‐carbohydrate diet and sleep status, depression, anxiety, and stress score

et al. 2020

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“…8 A cross-sectional study in Greece revealed that OSA patients with the highest quartile of total red meat intake were three times more likely to have severe OSA than those with the lowest quartile. 9 Consistently, several epidemiological studies found that low-energy diet, low carbohydrate diet, and Mediterranean diet were associated with a decreased risk of OSA severity, [10][11][12][13][14][15] while the intake of red meat, unprocessed red meat, and proarteriosclerotic diet (high in calories, fat, and simple carbohydrates and low in fish, fresh fruits, and vegetables) could contribute to OSA severity. 9,16 Although some evidence supported the protective effect of certain healthy dietary elements in treating OSA, only one study 17 examined the association between dietary factors and sleep apnea risk.…”

Section: Introductionmentioning

confidence: 80%

Association Between Eating Habits and Risk of Obstructive Sleep Apnea: A Population-Based Study

Du¹,

Duan²,

Zheng³

et al. 2021

NSS

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The effect of dietary factors on OSA remains unclear. This study was to investigate the association of obstructive sleep apnea (OSA) with individual and overall effects of eating habits among adult Chinese. Methods: A total of 9733 participants were selected from the baseline survey of the Guangzhou Heart Study. OSA was ascertained by Berlin Questionnaire. Food consumption was collected using a food frequency questionnaire, and eating patterns were extracted by principal component analysis. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated by the logistic regression model. Results: After adjustment for confounders, fried food intake with ≥1/week was associated with an increased risk of OSA (OR: 1.77, 95% CI: 1.37-2.27), while fruit consumption of ≥1/day was associated with a 26% reduced risk of OSA (OR: 0.74, 95% CI: 0.62-0.88). Three eating patterns were defined and labeled as pattern I, II, and III. Eating pattern III which had higher factor loadings of animal innards, fried food, salted food, carbonate, and non-carbonated beverages was associated with an increased risk of OSA (OR: 1.30, 95% CI: 1.09-1.55) when comparing the highest with the lowest tertile of pattern score, after adjusting for confounders; every 1-unit increment of pattern III score was associated with an increased risk of OSA (OR: 1.09, 95% CI: 1.04-1.14). Neither pattern I nor pattern II was observed to be associated with OSA risk. Conclusion: A higher frequency intake of fruits was associated with a reduced OSA risk and a diet with higher levels of consumption of animal innards, fried food, salted food, carbonated beverages, and non-carbonated beverages may increase the risk of OSA.

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Clinical Application of Gamitaeeumjowee-tang for Overweight or Obese Hypothyroidism Patients: A Retrospective Chart Review

Kim,

Won,

Kim

et al. 2023

JKOMOR

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Objectives: Weight gain is one of the symptoms of hypothyroidism and it could deteriorate thyroid function. Our objectives are to evaluate weight changes and analyze adverse events in overweight and obese women with hypothyroidism who were prescribed Gamitaeeumjowee-tang. Methods: A retrospective chart review was conducted using medical records of patients with hypothyroidism, who had body mass indexes (BMI) above 23 and were prescribed Gamitaeeumjowee-tang for 12 weeks between August 2017 and November 2022. Reported adverse events (AEs) were assessed by severity, causality and system-organ classes.Results: Thirty patients were included (mean±standard deviation, age 46.10±9.94 years, weight 70.52±11.18 kg, BMI 28.30±3.80 kg/㎡). The mean total weight loss of hypothyroidism patients was 5.45±2.77 kg, while the mean weight loss rate and mean BMI change were 7.66±3.41% and 2.18±1.07 kg/㎡, respectively. Among evaluated causality of adverse events, 'Unlikely' was predominant (80.8%) and severity assessment showed most of the symptoms were mild (91.7%). Conclusions: Gamitaeeumjowee-tang could be an option for hypothyroidism patients, who are overweight or obese, to lose weight and no serious adverse events occurred. Further well-designed clinical studies are recommended.

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Low carbohydrate diet-based intervention for obstructive sleep apnea and primary hypothyroidism in an obese Japanese man

Cited by 4 publications

References 13 publications

Association between a low‐carbohydrate diet and sleep status, depression, anxiety, and stress score

Association between a low‐carbohydrate diet and sleep status, depression, anxiety, and stress score

Association Between Eating Habits and Risk of Obstructive Sleep Apnea: A Population-Based Study

Clinical Application of Gamitaeeumjowee-tang for Overweight or Obese Hypothyroidism Patients: A Retrospective Chart Review

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