Low-coherence heterodyne photon correlation spectroscopy

Johnson, Joshua H.; Siefken, Shannon; Schmidt, Aaron J.; Corey, Robert B.; Saulnier, Paul

doi:10.1364/ao.37.001913

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Later, low-coherence interferometry has been introduced to photon correlation spectroscopy. Bizheva et al (1998) used the coherence gate to analyse the transition from single scattered light to light diffusion and its dependence on the system parameters, whereas Johnson et al (1998) used low-coherence heterodyne interferometry to suppress multiple scattered light and extend the applicability of photon correlation spectroscopy into the multiple scattering regime. Riva et al (1972) used the laser Doppler technique for blood velocity measurements at the fundus of the human eye and developed a bidirectional technique which allowed absolute measurements of the flow speed (Riva et al 1981).…”

Section: Doppler Octmentioning

confidence: 99%

Optical coherence tomography - principles and applications

et al. 2003

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We consider the use of single-photon counting detectors in coherence-domain imaging. Detectors operated in this mode exhibit reduced noise, which leads to increased sensitivity for weak light sources and weakly reflecting samples. In particular, we experimentally demonstrate the possibility of using superconducting single-photon detectors (SSPDs) for optical coherence-domain reflectometry (OCDR). These detectors are sensitive over the full spectral range that is useful for carrying out such imaging in biological samples. With counting rates as high as 100 MHz, SSPDs also offer a high rate of data acquisition if the light flux is sufficient.

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Section: Doppler Octmentioning

confidence: 99%

Optical coherence tomography - principles and applications

et al. 2003

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Comparative study of in‐vitro autofluorescence of normal versus non‐melanoma‐skin‐cancer cells at different excitation wavelengths

Garbarino

Scelfo

Paulone

et al. 2023

Journal of Biophotonics

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In this experimental study the autofluorescence of squamous carcinoma cells, stimulated by 6 different excitation wavelengths in the range 280-533 nm, has been compared with the autofluorescence of normal control keratinocytes. Skin cells were cultivated in vitro, to isolate their characteristic autofluorescence form the more complex one that would be originated by the complete skin tissue. Autofluorescence spectra in the visible range were complemented by absorption measurements. It was observed that the control cells showed characteristic emission (and absorption) structures due to typical endogenous chromophores [FAD and NAD(P)H, lipo-pigments, porphyrins], that were severely dumped in pathological cells. The autofluorescence spectra were then elaborated by multivariate analysis: after a first exploratory data analysis by means of Principal Component Analysis, the whole dataset was used to develop classification models using partial least squares-discriminant analysis, to differentiate between normal and pathological cells. This permitted us to identify the most suitable fluorescence spectral interval, in the 550-670 nm range, to discriminate between normal and pathological behavior, independently on the excitation wavelength.

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Low-coherence heterodyne photon correlation spectroscopy

Cited by 2 publications

References 8 publications

Optical coherence tomography - principles and applications

Optical coherence tomography - principles and applications

Comparative study of in‐vitro autofluorescence of normal versus non‐melanoma‐skin‐cancer cells at different excitation wavelengths

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