Low concentration effects of endosulfan insecticide on reproductive behaviour in the tropical cichlid fishSarotherodon mossambicus

Matthiessen, Peter; Logan, J.W.M.

doi:10.1007/bf01625587

Cited by 29 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their abilities to disrupt endocrine function and the reproductive physiology of fish have been well documented and an abundance of biochemical, behavioral, and physiological surrogate measures of exposure are currently available to toxicologists. For example, induction of the egg yolk protein precursor vitellogenin [7][8][9] and related markers [10], alterations to gonadal somatic indices [11] and gonad structure [12,13], reduced steroid hormone production [14,15], production of tumors [16], effects to sperm motility and egg production [11,17], and behavioral alterations [18,19] have all been described in fish exposed to environmental estrogens.…”

Section: Introductionmentioning

confidence: 99%

Altered Distribution of Lipid-Soluble Antioxidant Vitamins in Juvenile Sturgeon Exposed to Waterborne Ethynylestradiol

Palace¹,

Evans²,

Wautier³

et al. 2001

Environ Toxicol Chem

View full text Add to dashboard Cite

Studies in mammals have shown that exposure to estrogenic compounds can affect lipid metabolism and plasma concentrations of lipid-soluble vitamins. However, the potential for estrogenic contaminants to induce these effects in fish has not yet been examined. The ability of the estrogen analog ethynylestradiol (EE2) to alter concentrations of the lipid-soluble vitamins A and E in plasma, liver, and kidney was investigated in juvenile lake sturgeon (430 +/- 20 g). The EE2 was delivered to the sturgeon in the tank water at nominal concentrations of 0 (control), 15, 60, or 125 ng EE2/L for a period of 25 d. Concentrations of the egg yolk precursor, vitellogenin, increased dose dependently in plasma. Plasma vitamin E (tocopherol), A1 (retinol), and A2 (dehydroretinol) were elevated by the two highest EE2 treatments compared with the controls. Esterified storage forms of vitamin A were marginally lower in the livers of fish from the highest EE2 dose group, but vitamin E levels in the liver were not significantly affected. Concentrations of vitamin E and vitamin A were significantly depleted in the kidney of fish from the two highest EE2 dose groups. Total lipid content was elevated in the gonad of fish treated with the highest dose of EE2 compared with the controls. Altered lipid and vitamin distribution may be induced by estrogen to facilitate gonadal maturation in sturgeon. Results from these studies indicate that an examination of the implications for vitamin depletion by estrogenic contaminants in juvenile fish is warranted.

show abstract

Section: Introductionmentioning

confidence: 99%

Altered Distribution of Lipid-Soluble Antioxidant Vitamins in Juvenile Sturgeon Exposed to Waterborne Ethynylestradiol

Palace¹,

Evans²,

Wautier³

et al. 2001

Environ Toxicol Chem

View full text Add to dashboard Cite

show abstract

“…Only recently, in addition to a multitude of other sublethal effects, has endocrine disruption repeatedly been demonstrated as a further adverse effect of endosulfan (Matthiessen & Logan 1984, Inabraj & Haider 1988, Pandey 1988, Sinha et al 1991, Chakravorty et al 1992, Petit et al 1995, Bjerregaard et al 1998.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural alterations in the liver and intestine of carp Cyprinus carpio induced orally by ultra-low doses of endosulfan

Braunbeck¹,

Appelbaum²

1999

Dis. Aquat. Org.

View full text Add to dashboard Cite

In order to elucidate the importance of food-borne chemical contamination in fish, cytological and ultrastructural alterations in hepatocytes and enterocytes of common carp Cyprinus carpio L. exposed for 5 wk to 0.5 pg endosulfan (6,7,8.9,10,10-hexachloro-1,5,5a, 6,9a-hexahydro-6,9-methano-2,4,3-benzo-dioxyanthiepin-3-oxide) kg-' food dry weight, equivalent to an ultra-low dosis of 15 ng kg-' fish d-', were investigated by means of light and electron microscopy Observations on liver alterations were quantified by morphometric analysis Livers show enlargement of the nucleolus, increase in number and size of both Golgi flelds and rough endoplasmic reticulum (ER) lamellae, as well as proliferation of peroxisomes and lysosomes. Taken together, these alterations represent the morphological equivalent of a general stimulation of hepatic metabolism. Proliferation of the smooth ER is indicative of the onset of biotransformation processes under the influence of food-borne endosulfan. Further pathological processes in the liver were evident by glycogen and lipid depletion, invasion of phagocytic macrophages, and accun?ulation of myelinated bodies in endothehal cells of hepatic sinusoids. In the intestinal tract, exposure to endosulfan is associated with a complete lack of chylomicrons in the epithelia1 lining, w h~c h indicates disturbance of intestinal absorption. The reaction of the gut epithelium also included considerable distension of the intercellular space and an elevated number of lysosomal inclusions in enterocytes. An increased rate of mucous cell precursors was detectable, and rnacrophages were numerous. Results are consistent with endosulfan resorption by the intestinal epithelium and the coexistence of gut and liver ultrastructural changes at extremely low doses. Thus, the substantiation of patholog~cal alterations In organs sequentlally in contact with toxicants appears useful as a biomarker of pollutant exposure and effect. With regard to a chemical spill into the Rhine river at Basel, Switzerland, in November 1986, endosulfan, as a component of the mixture of toxic substances, may well have contributed to the overall toxicity of the chemicals released during the accident and the subsequent fish kill, less as a toxicant in itself than as a stimulant for the toxicity of other xenobiotics.

show abstract

“…These deviations from normal behavior in fish were further confirmed when such responses were not observed in the control setup with no extract. According to Matthiessen and Logan [42] as well as Scott and Crossman [43], fish behavior is an endpoint that is not often used in toxicological assessment in spite of the fact that this parameter has the potential for use in toxicological studies as a sensitive indicator of reproductive impairment or other expressions of toxicity. Little et al [44] observed that behavioral changes in fish occur 75% earlier than the onset of significant mortality in fish.…”

Section: Discussionmentioning

confidence: 99%

Sublethal Effects of Methanolic Extract of Raphia hookeri on the Reproductive Capacity of Clarias gariepinus

Afolayan

Borokini

Afolayan

2014

Advances in Zoology

View full text Add to dashboard Cite

Raphia hookerifruits are used for fishing in Nigeria due to their ichthyotoxic properties. This study investigated the toxic effects ofR. hookerion the reproductive capacity ofClarias gariepinus. The results from both short-term (96-hour test) and long-term (3-month sublethal test) bioassays revealed a linear relationship betweenR. hookeriextract dose and negative effects on the catfish. The percentage survival of both sexes of the catfish decreased with increasing extract concentration at short-term exposure, with LC50values of 600 mg/L and 800 mg/L for male and female, respectively. At long-term exposure, the reproductive capacity of 10–12-month-old male and female brood-stocks diminished at relatively higher concentrations ofR. hookerifruit extract, with the gravid females producing fewer and mostly unviable eggs. The fruit extract also affected the eggs’ hatchability and fry survival when the exposed gravid females were treated with pituitary hormone and sperms from unexposed males, while the exposed males were unable to sexually stimulate female brooders. Sperms and pituitary hormone from exposed males were infertile, leading to low percentage of hatched eggs and mortality of the few hatched fries within 24 hours. These results confirmed the ethnobotanical use of this fruit extract for fishing in Nigeria.

show abstract

Low concentration effects of endosulfan insecticide on reproductive behaviour in the tropical cichlid fishSarotherodon mossambicus

Cited by 29 publications

References 10 publications

Altered Distribution of Lipid-Soluble Antioxidant Vitamins in Juvenile Sturgeon Exposed to Waterborne Ethynylestradiol

Altered Distribution of Lipid-Soluble Antioxidant Vitamins in Juvenile Sturgeon Exposed to Waterborne Ethynylestradiol

Ultrastructural alterations in the liver and intestine of carp Cyprinus carpio induced orally by ultra-low doses of endosulfan

Sublethal Effects of Methanolic Extract of Raphia hookeri on the Reproductive Capacity of Clarias gariepinus

Contact Info

Product

Resources

About