Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency

Yan, Li; Sang, Xuan; Liu, Yang; Wang, Xiaoran; Liu, Jiahui; He, Xiongjun; Liu, Ying; Lu, Xiaoyan; Wang, Zhichong

doi:10.18240/ijo.2018.03.07

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…In addition, Szegedi et al found that a single HA application via eye drops may increase TFT in patients with dry eye syndrome [ 19 ]. Moreover, in vivo studies confirmed the increase in the thickness of the tear film (from 60 to 75 nm) induced by 0.1% HA solution in patients with lipid deficiency as a consequence of dry eye syndrome [ 20 ].…”

Section: Introductionmentioning

confidence: 92%

Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models

et al. 2021

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This work investigated the potential of a novel formulation of eye drops containing a non-steroidal anti-inflammatory drug—choline salicylate (CS)—and hyaluronic acid (HA). Thus, these drops may exert both anti-inflammatory and regenerative activity. The experiment was conducted through the careful characterization of physicochemical properties, stability, and quality of eye drops. Moreover, microbiological analysis, as well as penetration and cytotoxic studies, were performed. The UV, HPLC-UV, and HPLC-MS/MS methods were used to determine the purity and stability of CS. The penetration rate of CS was assessed using a hydrophilic membrane and ex vivo porcine cornea model. Additionally, the cytotoxic effects were evaluated using the SIRC cell line. The interaction between HA and CS was tested using size-exclusion chromatography and IR spectrophotometry. As a result, HA increased the viscosity of the drops, which prolonged their contact with the ocular surface, thus ensuring more effective penetration of CS into the corneal structure. After long-term storage, an interaction in the pharmaceutical phase between CS and HA was observed. However, this interaction did not affect the viability of rabbit corneal cells. Our findings showed that eye drops with CS and HA, stored at 2–8 °C in light-protected conditions, met the criteria of stability and safety.

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Section: Introductionmentioning

confidence: 92%

Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models

et al. 2021

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“… 13 , 15 However, ultrasonic moisture glasses can rapidly raise humidity to 90%. The glasses may prolong TBUT without dynamic changes in the tear film, including in the lipid layer, 20 , 21 as observed during usage of artificial tears. Thus, patients may not experience dryness or a decrease in visual acuity, which occurs just after using eye drops.…”

Section: Discussionmentioning

confidence: 97%

Effect of Ultrasonic Moisture Glasses on Dry Eye Signs and Symptoms

Onomura

Kawashima

Aketa

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeThis study was undertaken to evaluate the effect of a novel humidifying eyeglass-shaped device—ultrasonic moisture glasses—on dry eye signs and symptoms.MethodsA total of 18 subjects with dry eye symptoms underwent a crossover test. A water cartridge was set on each temple of the eyeglass-shaped device. All subjects randomly wore the device twice in different settings, each for 10 minutes. Subjects wore the glasses once with the cartridges filled with water (the intervention group), and once with the cartridges empty (the control group). The order was randomized. We evaluated tear film break-up time (TBUT) and fluorescein staining score just before, immediately after, and 10 minutes after wearing the device. We also assessed functional visual acuity (FVA), blink frequency, and visual analog scale (VAS) score just before and immediately after wearing the device.ResultsTBUT, blink frequency, and VAS improved in the intervention group (all P < 0.001) and exhibited significant differences between the intervention and control groups.ConclusionsWearing the ultrasonic moisture glasses for 10 minutes improved tear stability and decreased dry eye symptoms in this cohort of subjects.Translational RelevanceThese findings show that the ultrasonic moisture glasses are an effective device for improving dry eye signs and symptoms.

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“…The importance of mucin-like polymers for the performance of TFLL was confirmed in vivo by the capability of a 0.1% HA-induced increase (from <60 to 75 nm) of TFLL thickness of lipid-deficient individuals [ 16 ], and by the comparable effect for >1 h post-instillation of 3% diquafosol ophthalmic solution (a drug promoting the rapid secretion of MUC5AC) on the TFLL in healthy human eyes [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Such findings suggest that TFLL and endogenous and exogenous MMP may interact at the physiologically relevant timescale of seconds (H-bonding is a nanoseconds event), thus allowing for synchronous concerted action between the constituent of TFLL and AT. The impact of mucin-like polymers on TFLL was clinically demonstrated by the increase of the thickness of TFLL of lipid-deficient patients, from <60 to 75 nm, 15 min post-instillation of 0.1% HA [ 16 ], and by the similar effect of 3% diquafosol ophthalmic solution (strong MUC5AC secretatgogue) on the TFLL in healthy human eyes for more than 1 h post-instillation [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film

Eftimov

Yokoi

Melo

et al. 2021

IJMS

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Recent clinical findings suggest that mucomimetic polymers (MMP) can alter not only the texture of the aqueous tear but also the spreading and structure of the tear film (TF) lipid layer, thereby allowing for their synchronized performance in vivo. Thus, we aimed to evaluate in vitro (i) the capability of pharmaceutically applicable MMP to ensure the formation of post-evaporative ferning patterns (a characteristic feature of the “healthy” tear colloid) and (ii) the MMP interactions with human meibum films accessed in the course of blink-like deformations via Langmuir surface balance and Brewster angle microscopy (BAM). Four MMP were used- hyaluronic acid (HA), cross-linked hyaluronic acid (CHA), carboxymethyl cellulose (CMC) and gellan gum (GG)- at the concentrations of 0.0001%, 0.001%, 0.01%, 0.05% and 0.1%. Significant differences were observed in the MMP fern formation capability: CHA (≥0.001%) > HA (≥0.01%) = CMC (≥0.01%) > GG (≥0.05%). All MMP affected the spreading of meibum, with BAM micrographs revealing thickening of the films. CHA was particularly efficient, showing concentration-dependent enhancement of tear ferning and of meibomian layer structure, surfactant properties and viscoelasticity. Thus, endogenous and exogenous MMP may play key roles for the concerted action of the TF layers at the ocular surface, revealing novel routes for TF-oriented therapeutic applications.

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Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency

Cited by 11 publications

References 20 publications

Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models

Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models

Effect of Ultrasonic Moisture Glasses on Dry Eye Signs and Symptoms

Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film

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