Low concentrations of intravenous polygelines promote low‐molecular weight proteinuria

Abstract

Our study demonstrates that even low doses of the polygelines Haemaccel and Gelofusine profoundly attenuate the tubular reabsorption of the low-molecular weight protein beta2-m. Atrial natriuretic peptide does not affect tubular protein reabsorption. Therefore, the rise in albuminuria during ANP infusion most likely reflects alterations in glomerular permeability.

Indication for Different Mechanisms of Kidney Uptake of Radiolabeled Peptides

“…The hypothesis that Lys and Arg saturate those binding sites and, therefore, interfere with renal reabsorption of OCT is consistent with these findings (18,19). However, recently, gelatin-based plasma expanders inducing proteinuria (comparable with that observed in megalindeficient mice) have also been found to reduce renal uptake of OCT (7,8,(20)(21)(22). Though cationic amino acids contained in GF may be responsible for this finding (23), it cannot be excluded that megalin is also able to bind other than cationic compounds via alternative binding mechanisms (7).…”

Atrial natriuretic peptide and albuminuria in diabetic patients

“…However, it is evident that the ANP in saline had hardly any effect on urinary β 2 -m excretion. We have further confirmed this observation by studying the effects of ANP dissolved in saline or haemaccel on urinary albumin and β 2 -m excretion in healthy volunteers [3]. These data also demonstrate that infusion of ANP does not increase urinary excretion of β 2 -microglobulin.…”

Renal impact of fluid management with colloids: a comparative review

“…Also, in healthy volunteers, gelatin administration resulted in ␣ 1 -microglobulinuria (P Ͻ 0.01) and ␤ 2 -microglobulinuria (P Ͻ 0.01) [67] and produced a dose-dependent increase in excretion of ␤ 2 -MG [52]. In an isolated perfused porcine kidney model, gelatin perfusion decreased sodium resorption (P Ͻ 0.05) and increased glucose excretion (P Ͻ 0.05); however, the magnitudes of these effects were substantially smaller than those of HES perfusion [99].…”

“…A total of 92 studies were included in the review: 23 randomized clinical trials [6,11,12,15,17,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]; 17 non-randomized controlled clinical studies [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]; 16 non-controlled cohort clinical studies [54][55][56][57][58][59][60][61][62][63][64]…”