Low-density lipoprotein accumulation within a carotid artery with multilayer elastic porous wall: fluid–structure interaction and non-Newtonian considerations

Deyranlou, Amin; Niazmand, Hamid; Sadeghi, Mahmood

doi:10.1016/j.jbiomech.2015.08.002

Cited by 21 publications

(9 citation statements)

References 61 publications

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“…Furthermore, the increased pressure suggests a lower risk of arterial wall compression and collapse in this area and the distal areas; however, increased pressure on the plaque, even in the short time, if the vulnerable (unstable) plaque is close to rupture, can increase stresses in the fibrous area and result in its rupture [76], which enhances the risk of clot formation. In addition, increased pressure in the stenotic region can increase the permeability of the plasma to the wall, thereby increasing the accumulation and penetration of low-density lipoprotein (LDL) particles into the wall [86], which can accelerate the growth of arterial plaques over time. In the post-stenotic area, if endothelial cells are not damaged, increased pressure over time can result in arterial regeneration [74].…”

Section: Resultsmentioning

confidence: 99%

The impact of uniform magnetic field on the pulsatile non-Newtonian blood flow in an elastic stenosed artery

Sadeghi

Jahangiri

Saghafian

2020

J Braz. Soc. Mech. Sci. Eng.

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Since the effect of magnetic fields on blood flow is not fully understood or studied comprehensively, this paper, for the first time, addresses the effect of uniform magnetic fields with different intensities on the pulsatile non-Newtonian blood flow in an elastic artery with axially symmetrical single and double stenoses using the commercial software COMSOL Multiphysics 5.1. The results are suggestive that an increase in the percent stenosis increases the pressure drop, which is more dramatic in double stenosis. Moreover, for a given percent stenosis, increasing the Hartmann (Ha) number, in addition to increasing the pressure drop, increases the amount by which the pressure drop is raised. The shear stress results revealed that increasing the magnetic field intensity results in the reduction of the vortex region formed in the back of the stenosis, reducing the area prone to disease, which can resolve pathological issues. The impact of the magnetic field was found to be decreased by increasing the percent stenosis. It was also observed that the percentage difference between the maximum wall shear stresses for various percent stenoses is reduced by increasing the Ha number for both single and double stenoses.

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Section: Resultsmentioning

confidence: 99%

The impact of uniform magnetic field on the pulsatile non-Newtonian blood flow in an elastic stenosed artery

Sadeghi

Jahangiri

Saghafian

2020

J Braz. Soc. Mech. Sci. Eng.

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“…In fact, once the luminal lesion is accompanied by a low WSS, it enhances luminal surface concentration of lipoproteins like albumin and low-density lipoprotein, and consequently infiltration to the vascular wall. 20 , 21 Moreover, hypertension intensifies penetration in the elderly, with consequences such as intimal thickening, stenosis, and plaque formation, 5 that increase the risk of ischaemic and thromboembolic strokes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies

et al. 2021

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Atrial fibrillation (AF) can alter intra-cardiac flow and cardiac output that subsequently affects aortic flow circulation. These changes may become more significant where they occur concomitantly with ageing. Aortic ageing is accompanied with morphological changes such as dilation, lengthening, and arch unfolding. While the recognition of AF mechanism has been the subject of numerous studies, less focus has been devoted to the aortic circulation during the AF and there is a lack of such investigation at different ages. The current work aims to address the present gap. First, we analyse aortic flow distribution in three configurations, which attribute to young, middle and old people, using geometries constructed via clinical data. We then introduce two transient inlet flow conditions representative of key AF-associated defects. Results demonstrate that both AF and ageing negatively affect flow circulation. The main consequence of concomitant occurrence is enhancement of endothelial cell activation potential (ECAP) throughout the vascular domain, mainly at aortic arch and descending thoracic aorta, which is consistent with some clinical observations. The outcome of the current study suggests that AF exacerbates the vascular defects occurred due to the ageing, which increases the possibility of cardiovascular diseases per se.

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“…It may be assumed that such changes occur in vivo in the course of dyslipidaemia and contribute to arterial stiffening. Biochemical analyses have revealed that lipids accumulating on the membranes of atherosclerotic lesions are bonded with elastin already at the early stages of atherosclerosis [19,20].…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum low-density lipoprotein cholesterol concentration and arterial wall stiffness

Podolecka¹,

Grzeszczak²,

Żukowska-Szczechowska³

2018

Kardiol Pol

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Low-density lipoprotein accumulation within a carotid artery with multilayer elastic porous wall: fluid–structure interaction and non-Newtonian considerations

Cited by 21 publications

References 61 publications

The impact of uniform magnetic field on the pulsatile non-Newtonian blood flow in an elastic stenosed artery

The impact of uniform magnetic field on the pulsatile non-Newtonian blood flow in an elastic stenosed artery

Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies

Correlation between serum low-density lipoprotein cholesterol concentration and arterial wall stiffness

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