Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a useful marker for early-stage carotid atherosclerosis

Tamada, Makiko; Makita, Shinji; Abiko, Akihiko; Naganuma, Yujirou; Nagai, Mizuyoshi; Nakamura, Motoyuki

doi:10.1016/j.metabol.2009.09.009

Cited by 34 publications

(20 citation statements)

References 25 publications

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“…Fasting serum total cholesterol, atherogenic low-density cholesterol and TG concentrations tend to increase, whereas the anti-atherogenic high-density cholesterol concentrations tend to decrease. A decrease in anti-atherogenic HDL-C is indicative of an impaired reverse cholesterol transport pathway, 22,23 which over time accelerates atherosclerosis. The increase of the cardiac risk ratios total-C/LDL-C and LDL-C/HDL-C above the desirable range attests to an elevated CVD risk.…”

Section: Discussionmentioning

confidence: 99%

Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events

2011

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High blood pressure and elevated serum glucose levels often precede adverse cardiovascular events. The cardiovascular risk in otherwise healthy US adults with prehypertension (PreHTN) and/or prediabetes (PreDM), although perceived to be high, is largely undocumented. Coexisting PreHTN and PreDM in healthy US adults, correlates with untoward alterations in the commonly recognized cardiometabolic risk factors. The study investigated disease-free US adults (n¼4,561) from the NHANES database (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006). PreHTN and PreDM were diagnosed using JNC 7 and American Diabetes Association criteria, respectively; PreHTN was defined as systolic blood pressure 120-139 and/or diastolic blood pressure 80-89 mm Hg, and PreDM was defined as fasting blood sugar 100-125 mg dl À1 . The prevalence of coexisting PreHTN and PreDM (Co-PreHTN+PreDM) during the study period (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006) was 11.2±0.6%. Prevalence increased with age, was higher in men, and was lowest in non-Hispanic Blacks. The mean systolic blood pressure was 126.0 ± 0.5 mm Hg, diastolic blood pressure was 75.0 ± 0.5 mm Hg and fasting blood sugar was106.3 ± 0.3 mg dl À1 . Compared to adults with normotension, normoglycemia, subjects with CoPreHTN+PreDM displayed adversely altered cardiometabolic risk factors. Healthy men and women with Co-PreHTN+PreDM were, on average, overweight with a large waist circumference, displayed an exacerbated systemic inflammation and higher insulin resistance. They had elevated triglycerides, lower high-density lipoprotein cholesterol, leading to above average cardiac risk ratios and were significantly more likely to have two or three concomitant metabolic risk factors. High prevalence of Co-PreHTN+PreDM in healthy US adults, a strong correlate for dysregulated cardiometabolic risk factors, highlights a plausible accelerated pathway for early cardiovascular events.

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Section: Discussionmentioning

confidence: 99%

Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events

2011

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“…In 3,014 patients (mean age 54 years; 55% women), TG/HDL-C ratio and T-C/HDL-C ratio were related to insulin resistance assessed by the top quartile of the HOMA-IR, and the area under the ROC curves for predicting insulin resistance with TG/HDL-C ratio and T-C/HDL-C ratio were 0.745 and 0.707, respectively [19]. LDL-C/HDL-C ratio [20] as well as TG/HDL-C ratio [21] have advantages for standardization and identification of patients with an atherogenic lipoprotein profile as a surrogate maker of insulin resistance. Also in our study, both LDL-C/HDL-C and TG/HDL-C ratio were useful makers of insulin resistance, especially in all subjects or non-obese subjects.…”

Section: Discussionmentioning

confidence: 99%

Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

et al. 2010

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BackgroundThe aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults.MethodsThis cross-sectional study included 614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years. The study sample were 1,042 (74.8%) non-obese (BMI < 25.0 kg/m2) and 351 (25.2%) overweight (BMI ≥ 25 kg/m2) subjects. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. The areas under the curve (AUC) of the receiver operating characteristic curves (ROC) were used to compare the power of these serum markers.ResultsIn non-obese subjects, the best marker of insulin resistance was low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio of 0.74 (95% confidence interval (CI), 0.66-0.80). The HDL-C, triglyceride (TG)/HDL-C ratio, and non-HDL-C also discriminated insulin resistance, as the values for AUC were 0.31 (95% CI, 0.24-0.38), 0.69 (95% CI, 0.62-0.75) and 0.69 (95% CI, 0.62-0.75), respectively. In overweight subjects, the AUC for TG and TG/HDL-C ratio were 0.64 (0.58-0.71) and 0.64 (0.57-0.70), respectively. The optimal cut-off point to identifying insulin resistance for these markers yielded the following values: TG/HDL-C ratio of ≥1.50 and LDL-C/HDL-C ratio of ≥2.14 in non-obese subjects, and ≥2.20, ≥2.25 in overweight subjects. In non-obese subjects, the positive likelihood ratio was greatest for LDL-C/HDL-C ratio.ConclusionIn non-obese Japanese adults, LDL-C/HDL-C ratio may be the best reliable marker of insulin resistance.

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“…Metabolic disease remains a serious concern in the world, and people with metabolic syndrome are at increased risk of developing cardiovascular disease, stroke, and type 2 diabetes ( 9, 10 ). It is known that the functions and concentrations of serum HDL have strong inverse correlations with risk of metabolic syndrome and atherosclerotic cardiovascular disease (11)(12)(13). HDL is known to undergo dramatic modifi cation in structure and composition under the concerted actions of infl ammation and oxidative stress ( 14,15 ).…”

Section: Measurement Of Antioxidant Properties Of Hdlmentioning

confidence: 99%

Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

Song¹,

Song

et al. 2013

Journal of Lipid Research

119

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Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a useful marker for early-stage carotid atherosclerosis

Cited by 34 publications

References 25 publications

Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events

Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events

Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

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