Low-density lipoprotein subclasses: mechanisms of formation and modulation

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

“…This reduces the plasma HDL-C concentration and leads to TG-enriched, cholesteryl ester-depleted HDL and LDL particles. The TG in these particles is then hydrolyzed by hepatic lipase (HL), resulting in small HDL particles, which are excreted by the kidney and removed from the circulation at an enhanced rate 10) , and atherogenic small, dense LDL particles 11) . Thus, exaggerated postprandial hyperlipemia is an important feature of the 'atherogenic lipoprotein phenotype' (low HDL-C and high small, dense LDL), and the plasma HDL-C concentration can be viewed as an integrative marker of TG metabolism 12) .…”

Postprandial lipid metabolism: effects of dietary fatty acids

“…CM remnants have also been shown to penetrate the endothelium in much the same way as LDL and HDL (Mamo & Wheeler, 1994). As discussed elsewhere (Griffin, 1997), the importance of CETP and HL in determining quantitative and qualitative changes in HDL and LDL are the subject of debate and ongoing work, and for the purpose of the present account most emphasis will be placed on the role of dietary fatty acids in modulating postprandial triacylglycerol response, since present evidence suggests it is elevated triacylglycerol concentrations which drive the events described previously.…”

Dietas hiperglicídicas: efeitos da substituição isoenergética de gordura por carboidratos sobre o metabolismo de lipídios, adiposidade corporal e sua associação com atividade física e com o risco de doença cardiovascular

“…Isto reduz a concentração de c o l e s terol das partículas de HDL e gera partículas de LDL e HDL ricas em triglicérides, e depletadas em ésteres de colesterol. O conteúdo de triglicérides destas partículas é, então, hidrolisado pela lipase hepática, resultando em partículas pequenas de HDL que são removidas da circulação em um ritmo acelerado (38) e em partículas aterogênicas de LDL pequenas e densas (39). Ainda, as remanescentes de lipoproteínas ricas em triglicérides (VLDL e IDL), quando enriquecidas com colesterol, mostraram-se comprovadamente aterogênicas em animais (40).…”