Low-dose dopamine during cardiopulmonary bypass in patients with renal dysfunction

RETRACTED ARTICLE: Influence of two different volume replacement regimens on renal function in elderly patients undergoing cardiac surgery: comparison of a new starch preparation with gelatin

“…This is also supported by a study comparing off-pump coronary artery bypass surgery with cardiopulmonary bypass-based 767 Subclinical alterations in renal integrity detected by sensitive markers of tubular damage has been reported in the absence of overt changes in creatinine serum concentrations and creatinine clearance [17,18]. Thus, we also measured urinary excretion of kidney-specific proteins that may be helpful to detect early and discrete disturbances in kidney function: N-acetyl-beta-D-glucosamidase (beta-NAG) is a sensitive marker of lysosomal tubular damage [19], alpha-1-microglobulin is a marker for proximal tubular damage even when no histologic damage is seen [20], GST-alpha is exclusively associated with the proximal tubules [21], and GST-pi that is localized to the cells of the distal tubules, the thin loop of Henle, and the collecting ducts in the kidney [21,22]. We measured both isoenzymes of GST (alpha and pi) because they differ with regard to size and charge: one might expect some filtration of the alpha-form, but hardly any filtration of the negatively charged pi-enzyme through the glomerulus [21].…”

Low-dose dopamine: a systematic review

“…Of these, six were excluded; the remaining 15 trials [8, 30,31,32,33,34,35,36,37,38,39,40,41,42,43] were included in this meta-analysis. Articles were excluded for the following reasons: dopamine was combined with another agent [44,45,46], outcome variables not recorded [47], and pediatric patients were studied [48,49]. Overall, 970 patients were enrolled in the included studies.…”

Effect of Low-Dose Dopamine on Renal Function and Electrolyte Extraction During Cardiopulmonary Bypass

“…yaptıkları preoperatif renal disfonksiyon riski yüksek olan 36 hastada yaptıkları bir çalışmada dopamin ve nitroprussidi karşılaştırmışlar. Çalışma sonunda atılan sodyum/verilen sodyum oranını dopamin grubunda yüksek bulmuşlardır (19).…”

“…Böbrek performansındaki bu olumlu değişiklikleri klinik süreçte gözlemlemek akut böbrek yetmezliğinin tanımlanmasındaki farklılıklardan, böbrek yetmezliği sebeplerinin pek çok nedenden ötürü ortaya çıkmasından dolayı kolay olmamaktadır (4). Her ne kadar kalp cerrahisi hastalarında dopaminin idrar çıkışını artırdığı gösterilse de (9-11) böbrek fonksiyonlarında düzelme olduğu gösterilememiştir (10,11).…”