Low Dose Gadobenate Dimeglumine for Imaging Of Chronic Myocardial Infarction in Comparison With Standard Dose Gadopentetate Dimeglumine

Abstract

Low dose Gd-BOPTA resulted in significantly higher CNRinf-myo compared with standard dose Gd-DTPA in imaging of myocardial infarction with IR SSFP and IR GRE sequences. Demarcation of infarcted myocardium from the left ventricular cavity assessed by CNR showed no significant difference after application of either contrast media in both imaging techniques.

Ultra low-dose of gadobenate dimeglumine for late gadolinium enhancement (LGE) imaging in acute myocardial infarction: A feasibility study

“…As previously reported by other authors [15][16][17][18]20], a gadobenate dimeglumine dose of 0.1 mmol/kg BW generally provides an excellent image quality for determinations of IM size and volume.…”

“…Comparative CMR studies, both inter-individually [15,16] and intra-individually [17,18], have similarly shown that a dose of 0.1 mmol/kg BW Gd-BOPTA is equivalent to a double 0.2 mmol/kg BW dose of Gd-DTPA in terms of both scar depiction and quantification of necrotic tissue.…”

Myocardial delayed enhancement using a single dose (0.1 mmol/kg) of gadobenate dimeglumine: contrast resolution versus intraventricular blood and viable myocardium

“…For each variable, the box represents mean±standard deviation, whereas the vertical segment defines the observed range. Signal Intensity Contrast-to-noise ratio possible alternative approach is the intraindividual design, administering both contrast agents to each patient, as was done in two recent studies [8,11]. At any rate, our study should be regarded as a preliminary retrospective evaluation of the differences between Gd-BOPTA and a standard relaxivity contrast agent (Gd-DOTA) at the single dose of 0.1 mmol/kg, which provides a rationale for planning a randomized or an intraindividual study.…”

“…However, this approach has the double drawback of an unvaoidable lack of (histopathological) reference standard and the possible variability of the incidence of subendocardial infarctions in the two study arms. A bassa dose di Gd-BOPTA è migliore [11].…”

“…Tuttavia, questo approccio ha una duplice limitazione: l'inevitabile mancanza di uno standard di riferimento (istopatologico) e la possibile variabilità nei due bracci dello studio dell'incidenza dell'infarto subendocardico. In due recenti studi [8,11] …”