Low-dose intradermal versus intramuscular administration of recombinant hepatitis B vaccine: a comparison of immunogenicity in infants and preschool children

Egemen, Ayten; Akşit, Sadık; Kurugöl, Zafer; Erensoy, Selda; Bilgiç, Altınay; Akilli, Münevver

doi:10.1016/s0264-410x(98)80006-6

Cited by 41 publications

(22 citation statements)

References 10 publications

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“…Our finding that CD4 T cells generated by the higher DNA vaccination dose were greater in magnitude and function (i.e., the ability to secrete three cytokines and upregulate CD154) demonstrates that the dose is an important factor in determining the quality of immune responses. Despite the improved CD4 T-cell responses induced by the high-dose DNA, the subsequent administration of a recombinant gp120 protein did not boost this response, indicating either the ineffectiveness of the protein along with the QS-21 adjuvant to boost CD4 without subsequent priming or a null or even detrimental effect of repeated vaccinations with (4,9,24,31,36,49,53,64,69,78). These trials have generally used particle-based vaccines, but one trial demonstrated that antibody responses in volunteers receiving a hepatitis B vaccine i.d.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration

Bansal

Jackson²,

West

et al. 2008

J Virol

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Section: Discussionmentioning

confidence: 99%

Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration

Bansal

Jackson²,

West

et al. 2008

J Virol

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“…In particular, the availability of functionally active resident and infiltrating antigen-presenting cells (APCs) at the site of inoculation is crucial for the optimal capture and presentation of vaccine-derived antigens (Sumida et al, 2004). Among skin vaccine routes, intradermal (ID) delivery has been extensively tested in many clinical trials (Lambert and Laurent, 2008;Nicolas and Guy, 2008) including vaccination against rabies (Sabchareon et al, 1998;Charest et al, 2000;Vien et al, 2008), hepatitis B (Egemen et al, 1998;Henderson et al, 2000), and influenza (Frech et al, 2005;Belshe, 2007). It appears that the ID route is capable of inducing a humoral immune response that is equivalent or comparable to the one induced by the intramuscular or subcutaneous routes but with a lower dose of antigen, generally a fifth of the standard dose used for an intramuscular vaccine.…”

Section: Introductionmentioning

confidence: 99%

Intradermal Immunization Triggers Epidermal Langerhans Cell Mobilization Required for CD8 T-Cell Immune Responses

Liard

Munier

Joulin-Giet

et al. 2012

Journal of Investigative Dermatology

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The potential of the skin immune system for the generation of both powerful humoral and cellular immune responses is now well established. However, the mechanisms responsible for the efficacy of skin antigen-presenting cells (APCs) during intradermal (ID) vaccination still remain to be elucidated. We have previously demonstrated in clinical trials that preferential targeting of Langerhans cells (LCs) by transcutaneous immunization shapes the immune response toward vaccine-specific CD8 T cells. Others have shown that ID inoculation of a vaccine, which targets dermal APCs, mobilizes both the cellular and humoral arms of immunity. Here, we investigated the participation of epidermal LCs in response to ID immunization. When human or mouse skin was injected ID with a particle-based vaccine, we observed significant modifications in the morphology of epidermal LCs and their mobilization to the dermis. We further established that this LC recruitment after ID administration was essential for the induction of antigen-specific CD8 T cells, but was, however, dispensable for the generation of specific CD4 T cells and neutralizing antibodies. Thus, epidermal and dermal APCs shape the outcome of the immune responses to ID vaccination. Their combined potential provides new avenues for the development of vaccination strategies against infectious diseases.

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“…65 In contrast, a study using recombinant HBV vaccine at 0, 1, and 6 months reported comparable rates of seroprotection, although antibody titers were not significantly lower after ID vaccination (P > 0.05). 66 Comparable seroprotection rates were confirmed using recombinant HBV vaccine for children with human immunodeficiency virus infection 67 …”

Section: Hepatitis B Virus Vaccinementioning

confidence: 98%

Intradermal vaccination for infants and children

Saitoh

Aizawa

2016

Human Vaccines & Immunotherapeutics

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Intradermal (ID) vaccination induces a more potent immune response and requires lower vaccine doses as compared with standard vaccination routes. To deliver ID vaccines effectively and consistently, an ID delivery device has been developed and is commercially available for adults. The clinical application of ID vaccines for infants and children is much anticipated because children receive several vaccines, on multiple occasions, during infancy and childhood. However, experience with ID vaccines is limited and present evidence is sparse and inconsistent. ID delivery devices are not currently available for infants and children, but recent studies have examined skin thickness in this population and reported that it did not differ in proportion to body size in infants, children, and adults. These results are helpful in developing new ID devices and for preparing new vaccines in infants and children.

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Low-dose intradermal versus intramuscular administration of recombinant hepatitis B vaccine: a comparison of immunogenicity in infants and preschool children

Cited by 41 publications

References 10 publications

Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration

Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration

Intradermal Immunization Triggers Epidermal Langerhans Cell Mobilization Required for CD8 T-Cell Immune Responses

Intradermal vaccination for infants and children

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