Low-Dose Neoadjuvant External Beam Radiation Therapy for Soft Tissue Sarcoma

Devisetty, Kiran; Kobayashi, Wendy; Suit, Herman D.; Goldberg, Saveli; Niemierko, Andrzej; Chen, Yen-Lin E.; Raskin, Kevin A.; Schwab, Joseph H.; Springfield, Dempsey S.; Yoon, Sam S.; Hornicek, Francis J.; DeLaney, Thomas F.

doi:10.1016/j.ijrobp.2010.02.067

Cited by 16 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Devisetty et al [9] reviewed the results of 1765 patients with localized soft tissue sarcoma, treated at Massachusetts General Hospital, with low-dose (median, 20 Gy) neoadjuvant radiation. They found a strong correlation between brachytherapy and severe acute wound complications and a relatively smaller effect of either EBRT or IORT.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Significant Wound Complications Following Wide Resection of Extremity Soft Tissue Sarcomas

Schwartz

Rebecca

Smith

et al. 2013

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background Wound complications following resection of a localized soft tissue sarcoma have been associated with lower extremity location, large tumor volume, and use of preoperative radiation. Some of these wounds, however, show the potential for healing with local wound care and nonsurgical techniques. We are unaware of any published data establishing factors associated with nonhealing wounds that ultimately are treated with local or free vascularized tissue transfer.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk Factors for Significant Wound Complications Following Wide Resection of Extremity Soft Tissue Sarcomas

Schwartz

Rebecca

Smith

et al. 2013

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…Chemo n = 234 No chemo n = 851 (15) 109 (15) 34 (14) 131 (15) 38 000-47 999 243 (22) 75 (20) 168 (24) 58 (25) 185 (22) 48 000-62 999 283 (26) 101 (27) 182 (26) 63 (27) (27) 104 (27) 190 (27) 55 (23) 239 (27) 7-12.9% 346 (32) 120 (32) 226 (32) 69 (29) 277 (33) 13-20.9% 244 (22) 90 (24) 154 (22) 61 (26) (15) 59 (16) 99 (14) 25 (11) 133 (16) R 2 297 (27) 89 (23) 208 (29) 88 (37) 209 (24) Chemotherapy 0.42 -Yes 234 (22) 87 (23) 147 (21) The univariate analysis identified male gender, age older than 50 years, comorbidity, tumor larger than 8 cm, positive surgical margins, absence of perioperative radiotherapy and/or radiotherapy dose <60…”

Section: Resultsmentioning

confidence: 99%

Utilization pattern and survival outcomes of adjuvant therapies in high‐grade nonretroperitoneal abdominal soft tissue sarcoma: A population‐based study

Green

Jabbour

DeLaney

et al. 2017

Asia-Pac J Clncl Oncology

Self Cite

View full text Add to dashboard Cite

Summary: Nonretroperitoneal abdominal soft tissue sarcoma (NRA-STS) is a rare disease characterized by poor outcomes with limited data supporting its management. Our study indicates that adjuvant radiotherapy was associated with improved survival in high-grade NRA-STS, and higher radiotherapy doses may accentuate this benefit. AbstractBackground: Nonretroperitoneal abdominal soft tissue sarcoma (NRA-STS) is a rare disease with limited data supporting its management. Our study aimed to reveal the utilization patterns of adjuvant therapy and its potential survival benefits using the National Cancer Data Base. Materials:The analysis included patients with resected high-grade NRA-STS. Chi-square analysis was used to evaluate distribution of patient and tumor-related factors within treatment groups.The Kaplan-Meier and Cox proportional hazards model were utilized to evaluate overall survival according to treatment approach. Multivariate analysis was used to determine the impact of these factors on patients' outcome. Matched propensity score analysis was implemented to control for imbalance of confounding variables. Results:At median follow-up of 49 months, 5-year overall survival improved from 46% without adjuvant radiation therapy to 52% (P = 0.009) with radiotherapy delivery with a 30% reduction in hazard of death (95% confidence interval = 0.58-0.84). On multivariate analysis, age <50, tumor <8 cm, negative margins and radiotherapy delivery were significant predictors of improved survival. Chemotherapy was not associated with significant survival improvement (Hazard Ratios[HR]: 0.89, P = 0.28). Conclusion:Adjuvant radiotherapy was associated with improved survival in high-grade NRA-STS. Chemotherapy was not associated with a survival improvement; however, further studies are needed to refine treatment strategies.

show abstract

“…For post‐operative external beam boosts, a shrinking field technique was used that encompassed the tumor bed with ∼1.5 cm margins. The details of BRT Iridium‐192 and IORT electron boost techniques have been previously described . The delivery of an additional boost dose was at the discretion of the treating surgeon and radiation oncologist and somewhat institution‐dependent.…”

Section: Methodsmentioning

confidence: 99%

Role of post-operative radiation boost for soft tissue sarcomas with positive margins following pre-operative radiation and surgery

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Low-Dose Neoadjuvant External Beam Radiation Therapy for Soft Tissue Sarcoma

Cited by 16 publications

References 24 publications

Risk Factors for Significant Wound Complications Following Wide Resection of Extremity Soft Tissue Sarcomas

Risk Factors for Significant Wound Complications Following Wide Resection of Extremity Soft Tissue Sarcomas

Utilization pattern and survival outcomes of adjuvant therapies in high‐grade nonretroperitoneal abdominal soft tissue sarcoma: A population‐based study

Role of post-operative radiation boost for soft tissue sarcomas with positive margins following pre-operative radiation and surgery

Contact Info

Product

Resources

About