Low-Dose Oral Granisetron (1 mg) plus Intravenous Dexamethasone: Efficacy in Gynecologic Cancer Patients Receiving Carboplatin-Based Chemotherapy

Markman, Maurie; Kennedy, Alexander W.; Webster, Kenneth; Kulp, Barbara; Peterson, Gertrude; Belinson, Jerome L.

doi:10.1006/gyno.1998.5168

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…The efficacy of oral granisetron, both 1 mg twice daily and 2 mg once daily, in patients undergoing moderately or highly emetogenic chemotherapy, has been demonstrated in numerous clinical studies (Table 3) [10,[17][18][19][20][21][22][23][24][25][26][27][28]. In addition, 674 Granisetron for Nausea and Vomiting Receptor binding assays were performed in rat brain tissue, except for the 5-HT 1C and 5-HT 3 assays, which were performed in pig and mouse brain tissue, respectively.…”

Section: Acute Onsetmentioning

confidence: 99%

Granisetron: An Update on its Clinical Use in the Management of Nausea and Vomiting

Aapro

2004

The Oncologist

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ABSTRACTchemotherapy-induced, radiation-induced, and postoperative nausea and vomiting, and also reviews its use in special patient populations. Granisetron is a potent and highly selective 5-HT 3 -receptor antagonist that has little or no affinity for other receptors, a characteristic that is thought to underlie the favorable side-effect and safety profiles of this agent. Extensive clinical trial data have shown granisetron to be an effective and well-tolerated agent for the treatment of nausea and vomiting in the oncology and surgical settings. Granisetron has also been shown to be effective and well tolerated in special populations, such as patients refractory to antiemetic treatment, patients with hepatic or renal impairment, and children. Data also suggest that its safety profile and minimal potential for drug-drug interactions would make it an antiemetic agent of choice for elderly cancer patients. The Oncologist 2004;9:673-686

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